Catalog No.
RHC27902
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
APP secretase, CPSB, Cathepsin B, Cathepsin B1, CTSB, APPS
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P07858
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1L16
Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages., PMID:40168426
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1., PMID:39894408
Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer's disease through PI3K-Akt signaling., PMID:39304744
Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates., PMID:38837480
Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity., PMID:38342757
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma., PMID:37598461
The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project., PMID:36529369
Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration., PMID:35156579
Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates., PMID:34894942
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization., PMID:34802379
Interruption of endolysosomal trafficking leads to stroke brain injury., PMID:34363809
Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy., PMID:34083420
Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase., PMID:32979352
Role of major histocompatibility complex II antigen-presentation pathway genes in orange-spotted grouper infected with Cryptocaryon irritans., PMID:32924190
Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate., PMID:32843329
Rational Design of a Humanized Antibody Inhibitor of Cathepsin B., PMID:32212642
Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells., PMID:32086295
C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease., PMID:31092553
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion., PMID:30622337
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation., PMID:30019185
TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA., PMID:29018571
mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis., PMID:26925667
HIV-infected microglia mediate cathepsin B-induced neurotoxicity., PMID:26092112
Antithymocyte globulin facilitates alloreactive T-cell apoptosis by means of caspase-3: potential implications for monitoring rejection-free outcomes., PMID:25531894
Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages., PMID:25209871
Proteases as activators for cytotoxic prodrugs in antitumor therapy., PMID:24709544
Abundance of MMPs and cysteine cathepsins in caries-affected dentin., PMID:24356440
Endo-PDI is required for TNFα-induced angiogenesis., PMID:24103565
Inflammatory and immunological biomarkers are not related to survival in adults with Cystic Fibrosis., PMID:23860440
Influence of partial unfolding and aggregation of human stefin B (cystatin B) EPM1 mutants G50E and Q71P on selective cleavages by cathepsins B and S., PMID:23362198
Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis., PMID:21421874
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice., PMID:20133781
Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes., PMID:20110692
Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae., PMID:20107207
Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush., PMID:18775855
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer., PMID:16707449
Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma., PMID:15367886
Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection., PMID:11185708
For research use only. Not for human or drug use.
