Catalog No.
RHC15301
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Target
Alkaline phosphatase liver/bone/kidney isozyme, AP-TNAP, TNSALP, Alkaline phosphatase, tissue-nonspecific isozyme, ALPL
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05186
Applications
IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1K17
Ectonucleotidases and purinergic receptors in mouse prostate gland., PMID:40400995
Effects of asfotase alfa on fracture healing of adult patient with hypophosphatasia and literature review., PMID:40189581
Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia., PMID:40114282
Diagnosis and Treatment of Hypophosphatasia., PMID:40047955
Efficacy of asfotase alfa in a patient with adult-onset hypophosphatasia without obvious bone lesions: a case report with review of literature., PMID:39880615
Preclinical evaluation of the efficacy and safety of adeno-associated virus 8-tissue-nonspecific alkaline phosphatase-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia., PMID:39799564
Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report., PMID:39702252
Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168
Effectiveness of asfotase alfa for treatment of adults with hypophosphatasia: results from a global registry., PMID:38459585
Isolation and In Vitro Culture of Germ Cells and Sertoli Cells from Human Fetal Testis., PMID:38351447
Impressive clinical improvement and disappearance of neuropathic pain in an adult patient with hypophosphatasia treated with asfotase alfa., PMID:38325645
Hypophosphatasia: presentation and response to asfotase alfa., PMID:37993691
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma., PMID:37291203
Increased carotid intima-media thickening and antioxidized low-density lipoprotein in an anti-Ro60 SLE autoantibody subset., PMID:39055110
The molecular mechanism research of cartilage calcification induced by osteoarthritis., PMID:35611765
Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia., PMID:35303588
A Japanese single-center experience of the efficacy and safety of asfotase alfa in pediatric-onset hypophosphatasia., PMID:35197081
Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitro., PMID:35171372
Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development., PMID:35098920
Dental outcomes for children receiving asfotase alfa for hypophosphatasia., PMID:34175501
Hypophosphatasia., PMID:33931563
Investigation of ALPL variant states and clinical outcomes: An analysis of adults and adolescents with hypophosphatasia treated with asfotase alfa., PMID:33814268
Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion., PMID:33335129
Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia., PMID:33301963
Predictive Power of Bone Turnover Biomarkers to Estimate Bone Mineral Density after Kidney Transplantation with or without Denosumab: A post hoc Analysis of the POSTOP Study., PMID:32998144
Adult hypophosphatasia manifests in a marathon runner., PMID:32912883
Physiological blood-brain transport is impaired with age by a shift in transcytosis., PMID:32612231
Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells., PMID:32054534
Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase., PMID:32028019
Effect of Asfotase Alfa on Muscle Weakness in a Japanese Adult Patient of Hypophosphatasia with Low ALP Levels., PMID:31787692
Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration., PMID:31425530
Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy., PMID:31000369
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
Hypophosphatasia: Canadian update on diagnosis and management., PMID:30915507
No vascular calcification on cardiac computed tomography spanning asfotase alfa treatment for an elderly woman with hypophosphatasia., PMID:30825650
Considerations for high-yield, high-throughput cell enrichment: fluorescence versus magnetic sorting., PMID:30659223
Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates., PMID:30655187
Improvement of bone microarchitecture parameters after 12 months of treatment with asfotase alfa in adult patient with hypophosphatasia: Case report., PMID:30508901
Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy., PMID:30288020
Enzyme-replacement therapy in perinatal hypophosphatasia: Case report and review of the literature., PMID:30249491
Hypophosphatasia: From Diagnosis to Treatment., PMID:30203264
Spurious testosterone laboratory results in a patient taking synthetic alkaline phosphatase (asfotase alfa)., PMID:29709501
Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis., PMID:29528446
Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa., PMID:28888853
Glucomannan consumption elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-I, which is associated with increased production of protective factors for gut epithelial homeostasis in high-fat diet-fed rats., PMID:28739053
Transgelin mediates transforming growth factor-β1-induced proliferation of human periodontal ligament cells., PMID:28590058
Efficacy of anti-sclerostin monoclonal antibody BPS804 in adult patients with hypophosphatasia., PMID:28436937
Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial., PMID:28374482
The Pluripotent Stem-Cell Marker Alkaline Phosphatase is Highly Expressed in Refractory Glioblastoma with DNA Hypomethylation., PMID:28173571
Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis., PMID:28106886
For research use only. Not for human or drug use.
