Catalog No.
YHC25701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu136-Pro276
Predicted molecular weight
18.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07359
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD42b, GP-Ib alpha, Antigen CD42b-alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Platelet glycoprotein Ib alpha chain, GP1BA
A multi-color flow cytometric method for characterizing murine reticulated platelets using SYTO 13., PMID:40293201
Unique Patterns of Circulating Extracellular Vesicles in Preterm Infants During Adaptation to Extra-Uterine Life., PMID:40194994
Dynamics of a von Willebrand Factor A1 Autoinhibitory Module with O-Linked Glycans and Its Roles in Regulation of GPIbα Binding., PMID:40183925
CD19 chimeric antigen receptor-T cell therapy in murine immune thrombocytopenia., PMID:40139759
Association of glycoprotein 1b and miR-26a-5p levels with platelet function in Alzheimer's disease., PMID:40112326
Preventative and therapeutic effects of a novel humanized anti-glycoprotein Ibα fragment of antigen-binding region in a murine model of thrombotic thrombocytopenic purpura., PMID:39956431
[Immunohistochemical method of megakaryocytic lineage staining in bone marrow biopsy specimens as an additional pathomorphological differential diagnostic sign of primary myelofibrosis and essential thrombocythemia]., PMID:39943725
A novel antibody against GPIbα inhibits platelet function and thrombosis without increasing bleeding., PMID:39924011
Clot signature in patients with large vessel occlusion stroke and concomitant active cancer., PMID:39760182
Structure-resolved dynamics of type 2M von Willebrand disease., PMID:39756657
Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation., PMID:39738271
Like Father, Like Daughter: A Family With a Constitutional Thrombocytopenia Variant Due to a Novel Heterozygous Missense Mutation in GP1BA., PMID:39737636
Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout., PMID:39643071
Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues., PMID:39620384
The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia., PMID:39541612
Platelet Glycoprotein Ibα Cytoplasmic Tail Exacerbates Thrombosis During Bacterial Sepsis., PMID:39519103
Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates., PMID:39499978
Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging., PMID:39433750
Hemin-induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques., PMID:39387619
High‑fat diet‑induced LCN2 exacerbates myocardial ischemia‑reperfusion injury by enhancing platelet activation., PMID:39301623
The effects of complement-independent, autoantibody-induced apoptosis of platelets in immune thrombocytopenia (ITP)., PMID:39271523
Platelet changes and bleeding symptoms in children, adolescents, and adults with 22q11.2 deletion syndrome., PMID:39228058
Bernard-Soulier Syndrome: A Review of Epidemiology, Molecular Pathology, Clinical Features, Laboratory Diagnosis, and Therapeutic Management., PMID:39191409
Platelet-Type von Willebrand Disease: Complex Pathophysiology and Insights on Novel Therapeutic and Diagnostic Strategies., PMID:39191406
Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy., PMID:39147240
[Rare VPS33B gene mutation combined with GP1BA mutation causes severe decrease in plasma VWF levels: a case report and literature review]., PMID:39134495
Western Diet Modifies Platelet Activation Profiles in Male Mice., PMID:39125586
Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets., PMID:39088777
Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα., PMID:39072582
Modulation of Staphylococcus aureus gene expression during proliferation in platelet concentrates with focus on virulence and platelet functionality., PMID:39052660
New insights of glycoprotein Ib-IX-V complex organization and glycoprotein Ibα in platelet biogenesis., PMID:39046849
How unique structural adaptations support and coordinate the complex function of von Willebrand factor., PMID:38968155
[Pedigree Analysis and Molecular Mechanism Study of Hereditary Glanzmann Thrombasthenia Caused by Compound Heterozygous Mutation of the ITGA2B Gene]., PMID:38951065
High Levels of Triggering Receptor Expressed in Myeloid Cells-Like Transcript-1 Positive, but Not Glycoprotein 1b+, Microparticles Are Associated With Poor Outcomes in Acute Respiratory Distress Syndrome., PMID:38935146
A new platelet alloantigen (Efs2a) on glycoprotein GPIIIa leading to neonatal alloimmune thrombocytopenia., PMID:38924565
The compound pathogenic effects of a homozygous frameshift variant in the transmembrane region of GP9, causing Bernard-Soulier syndrome, with a missense variant in GP1BB., PMID:38923496
Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides-TLR4 Axis Downregulation., PMID:38891768
Reduction of ristocetin-induced platelet aggregation (RIPA) during storage despite plasma renewal: evidence for hemostatic importance of GPIbα shedding., PMID:38889268
The longevity-associated BPIFB4 gene guarantees vascular homeostasis and immune protection through platelets., PMID:38884925
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia., PMID:38845541
Exploring ligands that target von Willebrand factor selectively under oxidizing conditions through docking and molecular dynamics simulations., PMID:38829206
Linking Computational Fluid Dynamics Modeling to Device-Induced Platelet Defects in Mechanically Assisted Circulation., PMID:38768482
Extracorporeal membrane oxygenation aggravates platelet glycoprotein V shedding and δ-granule deficiency in COVID-19-associated acute respiratory distress syndrome., PMID:38763215
Membrane Tilt Drives Phase Separation of Adhesion Receptors., PMID:38759206
Binding Mechanism between Platelet Glycoprotein and Cyclic Peptide Elucidated by McMD-Based Dynamic Docking., PMID:38751042
Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome., PMID:38750089
Shedding light on GPIbα shedding., PMID:38728102
Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size., PMID:38704122
Essential role of glycoprotein Ibα in platelet activation., PMID:38701351
Improving platelet function following prophylactic platelet transfusion in patients with hematological malignancies., PMID:38682289
For research use only. Not for human or drug use.
