Catalog No.
RHB74601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Probable ATP-dependent RNA helicase DDX58, Retinoic acid-inducible gene I protein, RIG-1, DEAD box protein 58, RLR-1, DDX58, Retinoic acid-inducible gene 1 protein, Antiviral innate immune response receptor RIG-I, RIG-I-like receptor 1, RIG-I
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95786
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G65
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response., PMID:38331257
Molecular Signatures in Swine Innate and Adaptive Immune Responses to African Swine Fever Virus Antigens p30/p54/CD2v Expressed Using a Highly Efficient Semliki Forest Virus Replicon System., PMID:37298266
Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model., PMID:36851724
RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine., PMID:36426358
Transcriptome analysis reveals similarities and differences in immune responses in the head and trunk kidneys of yellow catfish (Pelteobagrus fulvidraco) stimulated with Aeromonas hydrophila., PMID:36055554
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes., PMID:35797939
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine., PMID:35577151
T cell and memory B cell responses in tetravalent DNA, tetravalent inactivated and tetravalent live-attenuated prime-boost dengue vaccines in rhesus macaques., PMID:34823910
TLR genetic variation is associated with Rotavirus-specific IgA seroconversion in South African Black infants after two doses of Rotarix vaccine., PMID:34740476
A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine., PMID:34603303
NanoString technology distinguishes anti-TIF-1γ+ from anti-Mi-2+ dermatomyositis patients., PMID:34043263
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation., PMID:33835418
Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway., PMID:33593967
From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies., PMID:33314705
Host gene expression modulated by Zika virus infection of human-293 cells., PMID:33059318
Angiogenic and Immune-Related Biomarkers and Outcomes Following Axitinib/Pembrolizumab Treatment in Patients with Advanced Renal Cell Carcinoma., PMID:32816890
Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus., PMID:32491861
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy., PMID:32427578
Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade., PMID:32371478
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade., PMID:31740809
Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade., PMID:31645452
Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages., PMID:31562757
N6-Methyladenosine Modification Controls Circular RNA Immunity., PMID:31474572
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles., PMID:31200750
CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways., PMID:31195953
Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells., PMID:31088527
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters., PMID:30909389
Diagnostic potential of sarcoplasmic myxovirus resistance protein A expression in subsets of dermatomyositis., PMID:30267437
Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells., PMID:30087859
Aberrant activation of the type I interferon system may contribute to the pathogenesis of anti-melanoma differentiation-associated gene 5 dermatomyositis., PMID:29947075
Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha., PMID:29247698
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production., PMID:29186193
RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA., PMID:28806404
Smith-Magenis Syndrome Patients Often Display Antibody Deficiency but Not Other Immune Pathologies., PMID:28286158
A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response., PMID:28279563
A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects., PMID:28077601
Non-Canonical Role of IKKα in the Regulation of STAT1 Phosphorylation in Antiviral Signaling., PMID:27992555
Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates., PMID:27214236
RIG-I ligand enhances the immunogenicity of recombinant H7HA protein., PMID:27106062
Antibody-dependent enhancement of dengue virus infection inhibits RLR-mediated Type-I IFN-independent signalling through upregulation of cellular autophagy., PMID:26923481
[Expression of retinoic acid-I nducible gene I in the muscle tissues of idiopathic inflammatory myopathies]., PMID:26712399
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I., PMID:26695369
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?, PMID:26616295
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus., PMID:26506431
Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells., PMID:26502803
IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation., PMID:26348439
Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant., PMID:26269188
Biology of Zika Virus Infection in Human Skin Cells., PMID:26085147
For research use only. Not for human or drug use.
