Catalog No.
RHB70501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:1000-1:2000
Target
Netrin-1, NTN1, Epididymis tissue protein Li 131P, NTN1L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95631
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G56
Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival., PMID:40461501
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity., PMID:39693351
Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice., PMID:37707834
Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor., PMID:37633969
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer., PMID:37532934
Pharmacological targeting of netrin-1 inhibits EMT in cancer., PMID:37532929
Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity., PMID:36711611
Corneal Epithelium-Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation., PMID:35648640
Hepatic inflammation elicits production of proinflammatory netrin-1 through exclusive activation of translation., PMID:35253915
Netrin-1 expression and targeting in multiple myeloma., PMID:34585999
Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity., PMID:34470826
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling., PMID:33883596
Netrin-1 reduces lung ischemia-reperfusion injury by increasing the proportion of regulatory T cells., PMID:32485133
Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis., PMID:31953174
Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression., PMID:31806640
Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome., PMID:30513621
Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer., PMID:30429890
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells., PMID:28373074
Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis., PMID:28251919
Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis., PMID:27502509
Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a., PMID:27509208
Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo., PMID:27430720
Inhibition of DNA methylation promotes breast tumor sensitivity to netrin-1 interference., PMID:27378792
Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas., PMID:26882243
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers., PMID:26859457
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis., PMID:26749424
Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis., PMID:26452536
Age-Dependent Netrin-1 Signaling Regulates NG2+ Glial Cell Spatial Homeostasis in Normal Adult Gray Matter., PMID:25926469
Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching., PMID:25754961
CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development., PMID:25656845
Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer)., PMID:25575591
Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction., PMID:25530182
Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation., PMID:25483983
Early netrin-1 expression impairs central nervous system remyelination., PMID:24942777
Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum., PMID:24867253
Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCα and FAK/Fyn in promoting mesenchymal stem cell motility., PMID:24738865
The expression of netrin-1 in the thymus and its effects on thymocyte adhesion and migration., PMID:24369474
Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s): Tampere Vascular Study (TVS)., PMID:24122613
Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination., PMID:23824572
Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells., PMID:23538444
PKCα is involved in the progression of kidney carcinoma through regulating netrin-1/UNC5B signaling pathway., PMID:23526078
c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance., PMID:23223444
GAP-43 dependency defines distinct effects of netrin-1 on cortical and spinal neurite outgrowth and directional guidance., PMID:23085079
TNF-α mediates macrophage-induced bystander effects through Netrin-1., PMID:22915753
Increased expression of netrin-1 and its deleted in colorectal cancer receptor in human diseased lumbar intervertebral disc compared with autopsy control., PMID:22588384
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization., PMID:22323486
Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia., PMID:22223243
Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells., PMID:21743013
AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke., PMID:21726647
Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors., PMID:21212933
For research use only. Not for human or drug use.
