Catalog No.
RHB59701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
RASGRP1, RASGRP, CalDAG-GEFII, RAS guanyl-releasing protein 1, Calcium and DAG-regulated guanine nucleotide exchange factor II, Ras guanyl-releasing protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95267
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1G36
B-cells absence in patients diagnosed as inborn errors of immunity: a registry-based study., PMID:38683392
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
Primary Immunodeficiency Disorders in children with Non-Cystic Fibrosis Bronchiectasis., PMID:32372587
Autoimmunity and immunodeficiency., PMID:31977526
Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis., PMID:31948396
Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice., PMID:31679751
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer., PMID:31237864
Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells., PMID:31067469
RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease., PMID:29155103
Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice., PMID:27279372
Association of established thyroid peroxidase autoantibody (TPOAb) genetic variants with Hashimoto's thyroiditis., PMID:27268232
CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice., PMID:27183569
Genetic variants associated with rheumatoid arthritis patients and serotypes in European populations., PMID:26939566
RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen Receptors., PMID:26851222
Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors., PMID:26714738
Renal microRNA- and RNA-profiles in progressive chronic kidney disease., PMID:26707063
Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies., PMID:24336796
Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice., PMID:23997211
LRRK2 expression is enriched in the striosomal compartment of mouse striatum., PMID:22850484
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases., PMID:21829393
Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts., PMID:21367774
A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells., PMID:19100522
Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells., PMID:18320039
Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane., PMID:17567957
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response., PMID:17190838
The role of RasGRPs in regulation of lymphocyte proliferation., PMID:16530850
RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling., PMID:16301621
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells., PMID:15657177
RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis., PMID:14970203
Cellular and subcellular localization of Ras guanyl nucleotide-releasing protein in the rat hippocampus., PMID:11738253
RasGRP is essential for mouse thymocyte differentiation and TCR signaling., PMID:11017103
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor., PMID:10918068
RasGRP links T-cell receptor signaling to Ras., PMID:10807788
For research use only. Not for human or drug use.
