Catalog No.
RHB44501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
SLIT2, Slit-2, SLIL3, Slit homolog 2 protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O94813
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1F99
Oculomotor axons use external and autocrine Slit signals for fasciculation, navigation, branching, and connectivity in mouse embryos., PMID:40470230
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875
TSHR-IGF-IR complex drives orbital fibroblast misbehavior in thyroid eye disease., PMID:39082947
Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice., PMID:37707834
Novel concept of Wilms' tumor development: involvement of pluripotential cells of ureteric bud., PMID:37209922
Identification of a novel amphioxus leucine-rich repeat receptor involved in phagocytosis reveals a role for Slit2-N-type LRR in bacterial elimination., PMID:37044216
Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma., PMID:36792623
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy., PMID:36742308
Mechanism of TLR4 mediated immune effect in transfusion-induced acute lung injury based on Slit2/Robo4 signaling pathway., PMID:35853810
Teprotumumab Divergently Alters Fibrocyte Gene Expression: Implications for Thyroid-associated Ophthalmopathy., PMID:35809263
Interleukine-17 Modulates Neurogenesis and Behavior Following Exposure to Trauma in Mice., PMID:35159158
A Phase 1 first-in-human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF-06730512 in healthy participants., PMID:34369667
PDL1 high expression without TP53, KEAP1 and EPHA5 mutations could better predict survival for patients with NSCLC receiving atezolizumab., PMID:33246647
Slit2 is a potential biomarker for renal impairment in systemic lupus erythematosus., PMID:33079290
Development of a Cell-Based Assay for the Detection of Neutralizing Antibodies to PF-06730512 Using Homogenous Time-Resolved Fluorescence., PMID:32166588
Low Expression and Promoter Hypermethylation of the Tumour Suppressor SLIT2, are Associated with Adverse Patient Outcomes in Diffuse Large B Cell Lymphoma., PMID:30739251
Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human Neutrophils., PMID:30510066
Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain., PMID:30085336
Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis., PMID:30021803
Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage., PMID:29610848
Robo1 Forms a Compact Dimer-of-Dimers Assembly., PMID:29307485
Slit2‑Robo1 signaling promotes the adhesion, invasion and migration of tongue carcinoma cells via upregulating matrix metalloproteinases 2 and 9, and downregulating E‑cadherin., PMID:27431199
Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4., PMID:26713366
TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation., PMID:26351669
Activation of Slit2-Robo1 signaling promotes liver fibrosis., PMID:26264936
Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis., PMID:24840330
Slit/Robo1 signaling regulates neural tube development by balancing neuroepithelial cell proliferation and differentiation., PMID:23438940
Frizzled-3a and Wnt-8b genetically interact during forebrain commissural formation in embryonic zebrafish., PMID:23438515
[Role of Slit-Robo signaling in the proliferation of human mucoepidermoid carcinoma Mc3 cells]., PMID:22366001
The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis., PMID:22198087
Effects of Roundabout 5 on adhesion, invasion and potential motility of human tongue carcinoma Tb cells., PMID:21933570
14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity., PMID:21780304
Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line., PMID:21459757
Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation., PMID:20944010
Characterization of axon guidance cue sensitivity of human embryonic stem cell-derived dopaminergic neurons., PMID:20637284
Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2., PMID:20471970
Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis., PMID:20438712
Embryonic corneal Schwann cells express some Schwann cell marker mRNAs, but no mature Schwann cell marker proteins., PMID:19387082
Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis., PMID:18201275
Slit2 involvement in glioma cell migration is mediated by Robo1 receptor., PMID:17968499
Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits., PMID:16840550
[The effect of protein kinase C alpha on expression of developmental genes during differentiation of mouse embryonic stem cells into neuron-like cells in vitro]., PMID:15840337
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons., PMID:15737744
Differential responsiveness to the chemorepellent Semaphorin 3A distinguishes Ipsi- and contralaterally projecting axons in the chick midbrain., PMID:11543622
Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein., PMID:11426225
Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain., PMID:10482237
For research use only. Not for human or drug use.
