Catalog No.
YHC23701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr50-Ala202
Predicted molecular weight
19.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P07203
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cellular glutathione peroxidase, Glutathione peroxidase 1, GPx-1, GPX1, GSHPx-1
Dissimilar Effects of Selenite and Selenium Nanoparticles on Skeletal Muscle Development Unrelated to GPx1 Activity During Adolescence in Rats., PMID:40507111
Optimizing Se- methylselenocysteine concentration to enhance glutathione peroxidase 1 expression and mitigate oxidative stress in senescent human fibroblast., PMID:40418552
Selenium corrects dysregulated mitophagy and lipophagy in obesity-related acute pancreatitis through the GPX1-Mfn2-PLIN2 axis., PMID:40327907
Evaluation of selenoproteins and proinflammatory cytokines in L-thyroxine-induced hyperthyroid rats: effects of selenium supplementation., PMID:40271987
The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population., PMID:40229954
Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease., PMID:40189792
The Role of Oxidative Stress-Related Gene Polymorphisms (SOD2, GPX1) in Severe Early Childhood Caries (S-ECC)., PMID:40142243
Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease., PMID:40059238
Oxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD., PMID:40000498
Molecular simulations guided drugs repurposing to inhibit human GPx1 enzyme for cancer therapy., PMID:39983407
The Inhibitory Effects of NCT503 and Exogenous Serine on High-Selenium Induced Insulin Resistance in Mice., PMID:39861441
Correlation between selenium levels and selenoproteins expression in idiopathic generalized epilepsy: a study from Karachi., PMID:39849427
CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels., PMID:39815613
GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn's disease., PMID:39695083
Effect of oleocanthal-rich olive oil on postprandial oxidative stress markers of patients with type 2 diabetes mellitus., PMID:39691690
Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells., PMID:39617443
Analysis of damaging non-synonymous SNPs in GPx1 gene associated with the progression of diverse cancers through a comprehensive in silico approach., PMID:39562776
Assessing antioxidant responses in C6 and U-87 MG cell lines exposed to high copper levels., PMID:39505290
Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1., PMID:39423458
Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells., PMID:39420311
Reciprocal regulation of oxidative stress and mitochondrial fission augments parvalbumin downregulation through CDK5-DRP1- and GPx1-NF-κB signaling pathways., PMID:39349423
Increased susceptibility of human limbal aniridia fibroblasts to oxidative stress., PMID:39303843
GPx1-ERK1/2-CREB pathway regulates the distinct vulnerability of hippocampal neurons to oxidative stress via modulating mitochondrial dynamics following status epilepticus., PMID:39214451
Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b., PMID:39120465
Selenium biomarkers and miR-7-5p in overweight/obese women., PMID:39084121
The Effect of High-Salt Diet on Oxidative Stress Production and Vascular Function in Tff3-/-/C57BL/6N Knockout and Wild Type (C57BL/6N) Mice., PMID:39074455
Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress., PMID:39048051
Polystyrene microplastics trigger testosterone decline via GPX1., PMID:38977086
Antioxidant and neurodevelopmental gene polymorphisms in prematurely born individuals influence hypoxia-related oxidative stress., PMID:38942829
Role of Corn Peptide Powder in Lipopolysaccharide-Induced Inflammatory Responses in 3T3-L1 Adipocytes., PMID:38931278
PAR level mediates the link between ROS and inflammatory response in patients with type 2 diabetes mellitus., PMID:38906011
Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line., PMID:38799687
Relationship between Serum Concentrations and Muscular Expressions of Selenoproteins on Selenium-Supplemented Insulin Resistance Mouse Model., PMID:38777758
Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy., PMID:38683407
The Important Role of GPX1 and NF-κB Signaling Pathway in Human Gastric Cancer: Implications for Cell Proliferation and Invasion., PMID:38670589
Rapid Selenoprotein Activation by Selenium Nanoparticles to Suppresses Osteoclastogenesis and Pathological Bone Loss., PMID:38621414
Sex-specific vulnerabilities in human astrocytes underpin the differential impact of palmitic acid., PMID:38552721
Implication of noise exposure on hearing with emphasis to hOGG1 and GPx-1 polymorphisms and HO-1 protein among textile workers., PMID:38147255
Amelioration of oxidative kidney damage in offspring by maternal trans-fatty acid exposure in mice by secoisolariciresinol diglucoside., PMID:37724399
Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma., PMID:37572455
The mRNA expression of genes encoding selected antioxidant enzymes and thioredoxin, and the concentrations of their protein products in gingival crevicular fluid and saliva during periodontitis., PMID:37390459
Hypothermia Treatment after Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice., PMID:37231852
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway., PMID:36868433
The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer., PMID:36295574
Selenoprotein GPX1 is a prognostic and chemotherapy-related biomarker for brain lower grade glioma., PMID:36155420
Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction., PMID:36063729
The impact of Zearalenone on heat-stressed skeletal muscle in pigs., PMID:35908787
Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene., PMID:35840016
Matrine inhibits advanced glycation end products-induced macrophage M1 polarization by reducing DNMT3a/b-mediated DNA methylation of GPX1 promoter., PMID:35597264
Selenium Supplementation Improved Cardiac Functions by Suppressing DNMT2-Mediated GPX1 Promoter DNA Methylation in AGE-Induced Heart Failure., PMID:35432721
For research use only. Not for human or drug use.
