Catalog No.
RHB19501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
CDC45L, PORC-PI-1, CDC45, Cell division control protein 45 homolog, CDC45L2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O75419
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1F30
Visualizing the dynamics of DNA replication and repair at the single-molecule level., PMID:38359974
The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis., PMID:37921901
Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes., PMID:36241664
CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans., PMID:24535824
Protein interaction and cellular localization of human CDC45., PMID:23364835
Cdc45 limits replicon usage from a low density of preRCs in mammalian cells., PMID:21390258
Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion., PMID:20124417
The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation., PMID:20065034
The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication., PMID:19223333
Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells., PMID:18286467
Human Cdc45 is a proliferation-associated antigen., PMID:17608804
Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase., PMID:17573775
Molecular architecture of the human GINS complex., PMID:17557111
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin., PMID:17046832
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus., PMID:15536124
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication., PMID:15329670
A monoclonal antibody against chicken thrombocytes reacts with the cells of thrombocyte lineage., PMID:15107551
Regulation of eukaryotic DNA replication at the initiation step., PMID:12546699
Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification., PMID:11024168
For research use only. Not for human or drug use.
