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Anti-ROCK2 Antibody (R1F05)

Catalog #:   RHB09101 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: IF, WB
Accession: O75116
Overview

Catalog No.

RHB09101

Species reactivity

Human, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, WB: 1:500-1:1000

Target

ROCK2, KIAA0619, Rho-associated, coiled-coil-containing protein kinase 2, p164 ROCK-2, ROCK-II, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase II, Rho-associated protein kinase 2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O75116

Applications

IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1F05

Data Image
  • Immunofluorescence
    Immunocytochemistry analysis of ROCK2(green) in Hela using ROCK2 antibody,and DAPI(blue)
  • Western blot
    Western blot analysis of ROCK2 in Hela, rat Brain, K562 lysates using ROCK2 antibody.
References

In Vitro Experiment Present ROCK2 Inhibition Promotes the Therapeutic Effect of Bevacizumab in the Treatment of Glioblastoma Multiforme., PMID:39792535

The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma., PMID:39307412

Augmentation of functional recovery via ROCK/PI3K/AKT pathway by Fasudil Hydrochloride in a rat sciatic nerve transection model., PMID:39007038

Modulating asthma-COPD overlap responses with IL-17 inhibition., PMID:37965351

Philadelphia chromosome-negative myeloproliferative chronic neoplasms: is clonal hematopoiesis the main determinant of autoimmune and cardio-vascular manifestations?, PMID:37915324

Involvement of Paired Immunoglobulin-Like Receptor B in Cognitive Dysfunction Through Hippocampal-Dependent Synaptic Plasticity Impairments in Mice Subjected to Chronic Sleep Restriction., PMID:36417104

Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's disease., PMID:35431138

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis., PMID:34917911

Critical regulation of follicular helper T cell differentiation and function by Gα13 signaling., PMID:34663730

Silencing ROCK1 ameliorates ventilator-induced lung injury in mice by inhibiting macrophages' NLRP3 signaling., PMID:34619496

Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease., PMID:33799579

Effect of anti-IL17 and/or Rho-kinase inhibitor treatments on vascular remodeling induced by chronic allergic pulmonary inflammation., PMID:33357114

Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA/ROCK pathway., PMID:32291804

Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF-Resistant Diabetic Macular Edema., PMID:32139595

Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway., PMID:31150636

Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis., PMID:31137925

Loss of ARHGEF1 causes a human primary antibody deficiency., PMID:30521495

Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma., PMID:30233389

The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity., PMID:30030370

Toll‑Like receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rho‑kinase in MCAO rats., PMID:29749502

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer., PMID:29382705

ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy., PMID:28821742

Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7., PMID:28674038

Cytokine mediators of chronic graft-versus-host disease., PMID:28665299

Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis., PMID:28554330

Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice., PMID:28460477

The Role of Rho/Rho-Kinase Pathway in the Pathogenesis of Cholesteatoma., PMID:28288476

RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro., PMID:28225457

Targeting ROCK2 rather than ROCK1 inhibits Ewing sarcoma malignancy., PMID:28112365

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings., PMID:27436361

Attenuation of obesity-induced insulin resistance in mice with heterozygous deletion of ROCK2., PMID:27163743

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism., PMID:26983850

ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis., PMID:26838736

In vivo expression and regulation of genes associated with vascularization during early response of sutures to tensile force., PMID:26825658

Immunohistochemical evaluation of ROCK activation in invasive breast cancer., PMID:26626121

Phosphorylation of nucleophosmin at threonine 234/237 is associated with HCC metastasis., PMID:26536659

Examination of segmental average mass spectra from liquid chromatography-tandem mass spectrometric (LC-MS/MS) data enables screening of multiple types of protein modifications., PMID:26388481

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2., PMID:25827955

Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification., PMID:25590559

In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity., PMID:25399539

Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency., PMID:25323425

Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats., PMID:24948002

Prostaglandin E(2)-dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2., PMID:24610576

Ser1333 phosphorylation indicates ROCKI activation., PMID:24168723

Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway., PMID:23954892

CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity., PMID:23644663

Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues., PMID:22986902

The effects of erythropoietin on RhoA/Rho-associated kinase expression in rat retinal explants cultured with glutamate., PMID:22711191

Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma., PMID:22495072

In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis., PMID:22363515

Datasheet

Document Download

Anti-ROCK2 Antibody (R1F05).pdf

 

$ 290
Product specifications
50 μg 290 100 μg 484

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Anti-ROCK2 Antibody (R1F05) [RHB09101]
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