Catalog No.
RHA88001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
KIAA0567, OPA1, Optic atrophy protein 1, Dynamin-like 120 kDa protein, mitochondrial
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O60313
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1E51
Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway., PMID:39983510
MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest., PMID:39586385
mCAUSE: Prioritizing mitochondrial targets that alleviate pancreatic cancer cell phenotypes., PMID:39310760
Pyroptosis of oral keratinocyte contributes to energy metabolic reprogramming of T cells in oral lichen planus via OPA1-mediated mitochondrial fusion., PMID:39289349
Photobiomodulation therapy with light-emitting diode in stimulating adipose tissue mitochondria., PMID:37851070
Creating Optimal Conditions for OPA1 Isoforms by Western Blot in Skeletal Muscle Cells and Tissue., PMID:37292669
Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3., PMID:34769322
Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice., PMID:34537761
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis., PMID:33816487
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes., PMID:33404293
Cell-Free Analysis of Mitochondrial Fusion by Fluorescence Microscopy., PMID:32529368
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses., PMID:32249716
Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress., PMID:32062073
Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors., PMID:31413070
Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the attenuation of postischemic mitochondrial injury afforded by sodium bicarbonate co-transporter (NBCe1) inhibition., PMID:30615862
Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy., PMID:30077733
Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats., PMID:29872094
ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes., PMID:29030231
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells., PMID:31966653
A multiple sclerosis-like disorder in patients with OPA1 mutations., PMID:27656661
Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency., PMID:27468686
Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA., PMID:25708700
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake., PMID:24085037
Atypical mitochondrial fission upon bacterial infection., PMID:24043775
TMEM126A is a mitochondrial located mRNA (MLR) protein of the mitochondrial inner membrane., PMID:23500070
Spinocerebellar ataxia: a rational approach to aetiological diagnosis., PMID:21892625
Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells., PMID:21642619
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage., PMID:21459773
The case for autoimmunity in glaucoma., PMID:20801114
Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts., PMID:20153825
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease., PMID:19605646
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons., PMID:19445933
Measuring mitochondrial shape changes and their consequences on mitochondrial involvement during apoptosis., PMID:18314742
OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear., PMID:17828551
OPA1 expression in the human retina and optic nerve., PMID:16857190
Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network., PMID:16249510
OPA1, associated with autosomal dominant optic atrophy, is widely expressed in the human brain., PMID:15700187
OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina., PMID:15505078
Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer., PMID:15161824
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space., PMID:12123827
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology., PMID:11847212
For research use only. Not for human or drug use.
