Catalog No.
YHC21701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly20-Lys154
Predicted molecular weight
16.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06748
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPM, Nucleolar protein NO38, Numatrin, NPM1, Nucleolar phosphoprotein B23, Nucleophosmin
A High-Throughput, Flow Cytometry Approach to Measure Phase Behavior and Exchange in Biomolecular Condensates., PMID:40502052
Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia., PMID:40501735
A Rare Case of Juvenile Myelomonocytic Leukemia (JMML) with t(3;5)(q25;q34)/NPM::MLF1 Fusion Gene in a Pediatric Patient., PMID:40497606
Probing condensate microenvironments with a micropeptide killswitch., PMID:40468084
Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival., PMID:40458728
FuHsi maintains nucleolar integrity., PMID:40435705
HTLV-I Basic Leucine Zipper Factor (sHBZ) Actively Associates with Nucleophosmin (B23) in the Nucleolus., PMID:40431738
Validation Study of Analytical Methods for Multiparameter Flow Cytometry-Based Measurable Residual Disease Assessment in Acute Myeloid Leukemia., PMID:40429651
The Novel Imiqualine EAPB02303 Is a Potent Drug for Treating Acute Myeloid Leukemia., PMID:40427634
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states., PMID:40412390
Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia., PMID:40400267
Genetic and Phenotypic correlates of clinical outcomes with Venetoclax in Acute Myeloid Leukemia: The GEN-PHEN-VEN study., PMID:40396900
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma., PMID:40393983
Expansion Microscopy Provides Nanoscale Insight into Nucleolar Reorganization and Nuclear Foci Formation during Nucleolar Stress., PMID:40391829
Venetoclax and hypomethylating agents versus induction chemotherapy for newly diagnosed acute myeloid leukemia patients: a systematic review and meta-analysis., PMID:40389911
Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations., PMID:40389402
Mapping of Functional Metabolic Phenotypes in Acute Myeloid Leukemia., PMID:40386930
Hybrid Se/melanin-like nanoparticles as ROS quenchers and inhibitors of amyloid aggregation., PMID:40379188
Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes., PMID:40377995
A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network., PMID:40363807
[Differences in clinical and laboratory features and survival between Chinese and Western patients with myelodysplastic neoplasm]., PMID:40355351
Nucleophosmin 1 inhibits the replication of influenza A virus by competitively binding viral RNA with viral proteins., PMID:40348279
Correlation of p53 oligomeric status and its subcellular localization in the presence of the AML-associated NPM mutant., PMID:40334261
Phase separation of MRG15 delays cellular senescence., PMID:40312521
CD200 in acute myeloid leukemia: marked upregulation in CEBPA biallelic mutated cases., PMID:40307896
Molecular monitoring versus standard clinical care in younger adults with acute myeloid leukaemia: results from the UK NCRI AML17 and AML19 randomised, controlled, phase 3 trials., PMID:40306832
A bioinformatics analysis and experimental validation of PDGFD as a promising diagnostic biomarker for acute myeloid leukemia., PMID:40295666
HOX-PBX Up-regulation Predicts Favorable Prognosis in NPM1-mutated Normal Cytogenetic AML via WNT Signaling., PMID:40295061
Heterobimetallic ferrocenyl-chromone compounds as selective inhibitors of amyloid aggregation., PMID:40288002
Competitive rDNA binding by dCas9 induces outside-in disassembly of the nucleolus., PMID:40286769
Clinical impact of tyrosine kinases related mutations in NPM1 mutated acute myeloid leukaemia: A report from the Northern Italy Leukaemia Group (NILG) multicentre randomized trial 02/06., PMID:40286636
A methionine/aspartate-rich synthetic peptide delineated from N-terminal region of nucleophosmin protein effectively protects against cadmium-induced toxicity., PMID:40273557
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein., PMID:40269321
Abnormal nucleoli architecture and aggregate formation in nucleophosmin mutated acute myeloid leukaemia., PMID:40260502
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies., PMID:40240912
RPS15a knockdown impedes the progression of B-ALL by inducing p53-mediated nucleolar stress., PMID:40239541
Expression, Prognosis, and Functional Analysis: <em>KDM5B</em> in Acute Myeloid Leukaemia (Non-M3)., PMID:40235240
IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia., PMID:40229904
Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China., PMID:40226311
Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms., PMID:40216030
TP53 Inactivation Confers Resistance to the Menin Inhibitor Revumenib in Acute Myeloid Leukemia., PMID:40196700
Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning., PMID:40171194
The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect., PMID:40163352
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate., PMID:40157629
Perturbed cell fate decision by schizophrenia-associated AS3MTd2d3 isoform during corticogenesis., PMID:40153497
Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I., PMID:40140990
Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia., PMID:40136427
Overexpression of βTrCP1 elicits cell death in cisplatin-induced senescent cells., PMID:40133262
TOM1L1 mediated the sort of tumor suppressive miR-378a-3p into exosomes and the excretion out of cells to promote ESCC progression., PMID:40123000
Prioritization of prognostic biomarkers regulated by calorie restriction in colon cancer through integrated biosignature analysis., PMID:40111533
For research use only. Not for human or drug use.
