Anti-MAP3K7 Antibody (R1E04)

Catalog No.

RHA64701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000

Target

Mitogen-activated protein kinase kinase kinase 7, TAK1, MAP3K7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O43318

Applications

IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R1E04

Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes., PMID:40484866

Exploring Genetic Factors Associated with Moniezia spp. Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach., PMID:40150341

The N6-methyladenosine pattern of MAP3K7 mediates the effects of sevoflurane on macrophage M2 polarization and cervical cancer migration and invasion., PMID:39944262

Global Phosphoproteomics Unveils Kinase-Regulated Networks in Systemic Lupus Erythematosus., PMID:36309313

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer., PMID:36270986

IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis., PMID:35183823

WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production., PMID:34576234

β-Caryophyllene attenuates lipopolysaccharide-induced acute lung injury via inhibition of the MAPK signalling pathway., PMID:34313776

The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6., PMID:34052945

The Transcription Factor NF-κB Mediates Thyrotropin-Stimulated Expression of Thyroid Differentiation Markers., PMID:32935630

Stat2 loss disrupts damage signalling and is protective in acute pancreatitis., PMID:32506441

Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK/NF-κB signaling pathways., PMID:32312253

CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs., PMID:32209473

TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation., PMID:32108376

In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6., PMID:31074699

Noncanonical TGFβ Pathway Relieves the Blockade of IL1β/TGFβ-Mediated Crosstalk between Tumor and Stroma: TGFBR1 and TAK1 Inhibition in Colorectal Cancer., PMID:30979739

Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑κB signaling pathway in vascular smooth muscle cells., PMID:30816448

O-GlcNAc Site Mapping by Using a Combination of Chemoenzymatic Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry., PMID:30657688

Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis., PMID:30541887

C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice., PMID:30407523

TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth., PMID:29703898

GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade., PMID:29507619

Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease., PMID:28820959

Upregulation of Bcl-2 and Its Promoter Signals in CD4+ T Cells during Neuromyelitis Optica Remission., PMID:28174515

Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy., PMID:28121444

Negative role of TAK1 in marginal zone B-cell development incidental to NF-κB noncanonical pathway activation., PMID:27121163

NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like cells., PMID:27708225

TAK1 maintains the survival of immunoglobulin λ-chain-positive B cells., PMID:27696624

A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis., PMID:26776603

TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production., PMID:26381601

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation., PMID:26285145

LATS2 inhibits the activity of NF-κ B signaling by disrupting the interaction between TAK1 and IKKβ., PMID:25946971

Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes., PMID:25776267

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner., PMID:25704183

Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation., PMID:24833394

TGFβ activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells., PMID:24801688

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3., PMID:24565101

TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress., PMID:24028082

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway., PMID:23778976

Genetic parameters and genome-wide association study of hyperpigmentation of the visceral peritoneum in chickens., PMID:23679099

In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation., PMID:23505428

4-mer hyaluronan oligosaccharides stimulate inflammation response in synovial fibroblasts in part via TAK-1 and in part via p38-MAPK., PMID:23298137

Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts., PMID:22749815

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release., PMID:22307082

A20 and ABIN-3 possibly promote regression of trehalose 6,6'-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1., PMID:22173278

FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization., PMID:21911455

The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity., PMID:21424379

A review of kinases implicated in pancreatic cancer., PMID:20090395

Activation of the alpha3 integrin affects TRAF6 function in the IL-1 signaling pathway of CACO-2 epithelial cells., PMID:20064081

Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling., PMID:19909372

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