Catalog No.
RHA34301
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, WB: 1:500-1:1000
Target
IKKB, IKK-beta, Serine/threonine protein kinase IKBKB, I-kappa-B-kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, IKBKB, IKK-B, NFKBIKB, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, IkBKB
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O14920
Applications
IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R1D37
[A novel fully human LAG-3 monoclonal antibody LBL-007 combined with PD-1 antibody inhibits proliferation, migration and invasion of tumor cells via blocking NF-κB pathway]., PMID:40415618
What are mice teaching us about psoriatic arthritis?, PMID:40265275
NF-ΚB Activation as a Key Driver in Chronic Lymphocytic Leukemia Evolution to Richter's Syndrome: Unraveling the Influence of Immune Microenvironment Dynamics., PMID:39596634
A novel functional IKBKE variant activating NFAT in a patient with polyarthritis and a remittent fever., PMID:39524436
Finding NEMO in the thymus., PMID:39432904
Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases., PMID:39352576
Associations of TRAF2 (rs867186), TAB2 (rs237025), IKBKB (rs13278372) Polymorphisms and TRAF2, TAB2, IKBKB Protein Levels with Clinical and Morphological Features of Pituitary Adenomas., PMID:39061149
Role of Skewed X-Chromosome Inactivation in Common Variable Immunodeficiency., PMID:38265673
Tubermycin B coated on Galactosylated Chitosan Nanoparticles synthesized by eco-friendly method ameliorates intracellular free radical production and reduces oxidative stress, reducing phosphorylation of IKKα/β/pIкBα/NF-кB pathway., PMID:37843350
Probiotic-fermented Portulaca oleracea L. alleviated DNFB-induced atopic dermatitis by inhibiting the NF-κB signaling pathway., PMID:37156447
ISG20L1 acts as a co-activator of DAPK1 in the activation of the p53-dependent cell death pathway., PMID:36855954
Inflammatory cytokine-enriched microenvironment plays key roles in the development of breast cancers., PMID:36704829
Regulatory effect of IL-38 on NF-κB pathway in systemic lupus erythematosus., PMID:36621308
ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression., PMID:36435834
Asprosin Exacerbates Endothelium Inflammation Induced by Hyperlipidemia Through Activating IKKβ-NF-κBp65 Pathway., PMID:36401667
Resvega, a Nutraceutical Preparation, Affects NFκB Pathway and Prolongs the Anti-VEGF Effect of Bevacizumab in Undifferentiated ARPE-19 Retina Cells., PMID:36233006
Application of an antibody microarray for serum protein profiling of coronary artery stenosis., PMID:36166954
Oral administration of Helianthus annuus leaf extract ameliorates atopic dermatitis by modulation of T cell activity in vivo., PMID:36108372
Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production., PMID:36077193
IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus., PMID:35930382
Differential Contribution of NF-κB Signaling Pathways to CD4+ Memory T Cell Induced Activation of Endothelial Cells., PMID:35769477
Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure., PMID:35641486
Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis., PMID:35624133
TRAF3 plays a role in lupus nephritis by regulating Th17 cell and Treg cell balance as well as NF-κB signaling pathway in mice., PMID:35416178
Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice., PMID:34720748
IκB Kinase-β Regulates Neutrophil Recruitment Through Activation of STAT3 Signaling in the Esophagus., PMID:34311141
Therapeutic effects of quinine in a mouse model of atopic dermatitis., PMID:34240224
Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling., PMID:34184086
Down-Regulation of LOC645166 in T Cells of Ankylosing Spondylitis Patients Promotes the NF-κB Signaling via Decreasingly Blocking Recruitment of the IKK Complex to K63-Linked Polyubiquitin Chains., PMID:33717069
Icaritin inhibits PD-L1 expression by Targeting Protein IκB Kinase α., PMID:33354776
Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway., PMID:33101583
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53., PMID:33097607
NeMO mutations: a rare cause of monogenic Behçet-like disease., PMID:32954429
Panax notoginseng saponin R1 modulates TNF-α/NF-κB signaling and attenuates allergic airway inflammation in asthma., PMID:32771949
Improving the diagnostic efficiency of primary immunodeficiencies with targeted next-generation sequencing., PMID:32531373
Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages., PMID:32492108
The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis., PMID:32221968
Small molecule inhibitors of IκB kinase β: A chip-based screening and molecular docking simulation., PMID:32205046
Rab11 activation by Ik2 kinase is required for dendrite pruning in Drosophila sensory neurons., PMID:32059017
Inferring the transcriptional regulatory mechanism of signal-dependent gene expression via an integrative computational approach., PMID:32052437
Successful Allogeneic Stem Cell Transplantation in Nuclear Factor-Kappa B Essential Modulator Deficiency Syndrome After Treosulfan-Based Conditioning: A Case Report., PMID:32035679
T Cell Impairment Is Predictive for a Severe Clinical Course in NEMO Deficiency., PMID:31965418
Infliximab therapy for inflammatory colitis in an infant with NEMO deficiency., PMID:31713830
Hsp-27 and NF-κB pathway is associated with AR/AR-V7 expression in prostate cancer cells., PMID:30807779
Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia., PMID:30723530
Engagement of Fas differentially regulates the production of LPS-induced proinflammatory cytokines and type I interferons., PMID:30536547
Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library., PMID:30176143
The Glycolytic Enzyme PFKFB3 Controls TNF-α-Induced Endothelial Proinflammatory Responses., PMID:30171427
IKKε aggravates inflammatory response via activation of NF-κB in rheumatoid arthritis., PMID:29687872
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21., PMID:29667579