Catalog No.
RHD26201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
TPH1, MGC119994, TPRH, TRPH, Tryptophan 5-hydroxylase 1, Tryptophan Hydroxylase, TPH1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P17752
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1C55
Mast cells help organize the Peyer's patch niche for induction of IgA responses., PMID:38427721
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520
CD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica., PMID:38350043
Serological Investigation of Persistent Villous Atrophy in Celiac Disease., PMID:37753949
Rituximab induces a transient fluctuation of peripheral and follicular helper T cells in neuromyelitis optica spectrum disorder., PMID:37536049
Hypertrophic cardiomyopathy induces changes in the tryptophan-5-hydroxylase, serotonin transporter and serotonergic receptors expressions., PMID:36657118
Triptófano-5-hidroxilasa, transportador de serotonina y receptores serotoninérgicos en miocardiopatía dilatada., PMID:36472833
TPH1 and 5-HT7 Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma., PMID:34771469
Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury., PMID:34507634
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor., PMID:33432230
IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro., PMID:31519333
PD-1+CXCR5-CD4+T cells are correlated with the severity of systemic lupus erythematosus., PMID:31180450
[Metabolic analysis of serotonin system in serum and gastric tissues of ovalbumin-induced allergic mice]., PMID:29973322
Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments., PMID:29849496
Increase in chromogranin A- and serotonin-positive cells in pouch mucosa of patients with ulcerative colitis undergoing proctocolectomy., PMID:29803758
Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites., PMID:29576437
Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish., PMID:26437856
[Difference in target antigens between central tolerance and peripheral tolerance deficiencies]., PMID:26213192
Gastrointestinal immunity against tryptophan hydroxylase-1, aromatic L-amino-acid decarboxylase, AIE-75, villin and Paneth cells in APECED., PMID:25805658
Disease specificity of anti-tryptophan hydroxylase-1 and anti-AIE-75 autoantibodies in APECED and IPEX syndrome., PMID:25463430
Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice., PMID:24700614
Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine., PMID:24603700
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism., PMID:24558199
Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells., PMID:24468700
Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity., PMID:23182718
Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition., PMID:22819790
Neuronal serotonin regulates growth of the intestinal mucosa in mice., PMID:22609381
Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension., PMID:22525513
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice., PMID:22330338
A novel murine model of severe pulmonary arterial hypertension., PMID:21868504
Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease., PMID:19301552
Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain., PMID:19233335
Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia., PMID:19015006
Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain., PMID:18839395
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding., PMID:17973628
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II., PMID:17727633
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice., PMID:17622221
Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice., PMID:17256748
Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies., PMID:16581041
Influence of polysaccharide coating on the interactions of nanoparticles with biological systems., PMID:16118015
Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons., PMID:15246835
Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques., PMID:15199371
For research use only. Not for human or drug use.
