Catalog No.
RHG13302
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
Apoptosis regulator Bcl-X, BLC2L, Bcl-2-like 1 protein bclxl, BCL2L, BCL2L1, BCLX, Bcl 2 L1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q07817
Applications
IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4 ℃ short term (1-2 weeks).
Store at -20 ℃ 12 months.
Store at -80 ℃ long term.
Clone ID
R1B87
Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors., PMID:40442785
Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration., PMID:40268279
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy., PMID:40113751
BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors., PMID:39365864
Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells., PMID:39196800
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs., PMID:38818652
Profiling of BCLxL Protein Complexes in Non-Small Cell Lung Cancer Cells via Multiplexed Single-Molecule Pull-Down and Co-Immunoprecipitation., PMID:38728439
Peritoneal B1 and B2 cells respond differently to LPS and IL-21 stimulation., PMID:38615627
Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment., PMID:37488586
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer., PMID:36622698
Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure., PMID:35641486
Strategies to Reduce the On-Target Platelet Toxicity of Bcl-xL Inhibitors: PROTACs, SNIPERs and Prodrug-Based Approaches., PMID:35263486
IgM-MM is predominantly a pre-germinal center disorder and has a distinct genomic and transcriptomic signature from WM., PMID:34792571
A comprehensive analysis of different gene classes in pancreatic cancer: SIGLEC15 may be a promising immunotherapeutic target., PMID:34515878
Multiple myeloma with t(11;14)-associated immature phenotype has lower CD38 expression and higher BCL2 dependence., PMID:34288263
Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells., PMID:33930385
Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors., PMID:33687950
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma., PMID:33368455
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer., PMID:33256808
In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma., PMID:33105692
Development of Conformational Antibodies to Detect Bcl-xL's Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells., PMID:33076337
Selective Affimers Recognise the BCL-2 Family Proteins BCL-xL and MCL-1 through Noncanonical Structural Motifs*., PMID:32961017
Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression., PMID:32821075
The BCL-2 family protein inhibitor ABT-737 as an additional tool for the treatment of EBV-associated post-transplant lymphoproliferative disorders., PMID:32623836
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1., PMID:32543276
Qualitative Ras pathway signature for cetuximab therapy reveals resistant mechanism in colorectal cancer., PMID:32216031
Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition., PMID:32103153
Adalimumab changes the expression profile of selected BCL-2 family genes., PMID:32068934
Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls., PMID:31906916
Heterogeneous Pattern of Dependence on Anti-Apoptotic BCL-2 Family Proteins upon CHOP Treatment in Diffuse Large B-Cell Lymphoma., PMID:31801186
Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia., PMID:31066008
Establishment of Systems to Enable Isolation of Porcine Monoclonal Antibodies Broadly Neutralizing the Porcine Reproductive and Respiratory Syndrome Virus., PMID:30972067
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo., PMID:30962322
Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model., PMID:30852912
Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy., PMID:30728358
Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma., PMID:30635792
Isolation of Synthetic Antibodies Against BCL-2-Associated X Protein (BAX)., PMID:30536015
Quantification of BCL-2 Family Members by Flow Cytometry., PMID:30536005
IL-21 and anti-CD40 restore Bcl-2 family protein imbalance in vitro in low-survival CD27+ B cells from CVID patients., PMID:30464201
Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors., PMID:30384408
Overexpression of miR‑361‑5p plays an oncogenic role in human lung adenocarcinoma through the regulation of SMAD2., PMID:30365047
MEK1/2 inhibition by binimetinib is effective as a single agent and potentiates the actions of Venetoclax and ABT-737 under conditions that mimic the chronic lymphocytic leukaemia (CLL) tumour microenvironment., PMID:29767411
Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors., PMID:29540581
Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells., PMID:29507226
Apoptosis and cell cycle aberrations in epithelial odontogenic lesions: An evidence by the expression of p53, Bcl-2 and Bax., PMID:29476674
Mechanisms of platelet clearance and translation to improve platelet storage., PMID:29475962
Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer., PMID:29391599
Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-x L and Mcl-1., PMID:29368032
Human antibody-based chemically induced dimerizers for cell therapeutic applications., PMID:29200207
The MIP-1α autocrine loop contributes to decreased sensitivity to anticancer drugs., PMID:29057477
For research use only. Not for human or drug use.
