Catalog No.
YHC15101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Ser231
Predicted molecular weight
27.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05177
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hydroperoxy icosatetraenoate dehydratase, Cytochrome P450-P3, Cytochrome P450 4, CYP1A2, Cholesterol 25-hydroxylase, CYPIA2, Cytochrome P(3)450, Cytochrome P450 1A2
Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes., PMID:40507787
Anemarrhena asphodeloides Bunge-Fritillaria Cirrhosae Bulbus Herb Pair Alleviates Ovalbumin-Induced Asthma by Regulating Arachidonic Acid Pathway., PMID:40453213
Tris(2-chloroisopropyl) phosphate (TCPP) decreases CYP1A1, CYP1A2, and CYP1B1/CYP2B expression and activities through potential interactions between AhR and NRF2 pathways in the HepG2 cell line., PMID:40412367
Fluvoxamine, an inhibitor of CYP1A2, improves CS-induced pulmonary inflammation through estrogen deficiency., PMID:40381743
Unraveling the molecular mechanisms of PFOA in clear cell renal cell carcinoma through network toxicology and molecular docking strategies., PMID:40359556
Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia., PMID:40347835
Pharmacogenetic pilot study of CYP2D6 and CYP1A2 genes in Italian patients with non-dystrophic myotonia and myotonic dystrophy treated with mexiletine., PMID:40324568
ADMET parameters of tacrine and its metabolites confirm unsuitability of Sus scrofa f. domestica model to study tacrine-associated hepatotoxicity., PMID:40319996
Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage-Dependent Calcium Channels and Protein Kinase C., PMID:40308215
CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner., PMID:40293922
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver., PMID:40291109
Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized., PMID:40220706
Multi-omics perspective on Huoluo Xiaoling Pellet: key bioactive compounds and related mechanisms for the treatment of knee osteoarthritis., PMID:40210178
In vitro-in vivo scaling of cytochrome P450-mediated metabolic clearance using a relative activity factor approach., PMID:40199158
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I: A Review of the Pharmacokinetic Literature and Proposed Changes., PMID:40198781
Evaluation of pharmacogenomic testing to identify cytochrome P450 and SLCO1B1 enzymes and adverse drug events: A non-experimental observational research., PMID:40193664
CYP1A2 contributes to the metabolism of mefloquine: Exploration using in vitro metabolism and physiologically-based pharmacokinetic modelling., PMID:40187114
Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation., PMID:40180188
Bioinformatics identification of shared signaling pathways and core targets linking Benzo[a]pyrene exposure to HCC progression., PMID:40174762
In silico molecular docking and predictive ADME properties, in vitro antioxidant scavenging capacities, and in vivo pharmacological activities to study the potential of Pterocarpus mildbraedii's Harms (Fabaceae) in preventing vaginal dysbiosis and risk factors for cardiovascular disease in an estropause rat model., PMID:40147737
Maternal MitoQ Treatment Is Protective Against Programmed Alterations in CYP Activity Due to Antenatal Dexamethasone., PMID:40142951
Toxicological insights into graphene family materials: Cytochrome P450 modulation and cellular stress in liver cells., PMID:40138895
Hepatic Impairment and the Differential Effects on Drug Clearance Mechanisms: Analysis of Pharmacokinetic Changes in Disease State., PMID:40136001
Effects of magnolol on the liver antioxidant status in rats with diabetes., PMID:40126860
Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the in vivo prediction of individual hepatic clearance., PMID:40115928
Cytochrome P450 Enzyme-Mediated Enantioselective Biotransformation of Chiral Fungicide Tebuconazole in Earthworm., PMID:40098277
Synergistic Artemisia monosperma with royal jelly: antibacterial, antioxidant, antibiofilm, and anti-Alzheimer assay., PMID:40082328
LEPR gene polymorphisms and pneumonia risk in Taiwanese schizophrenia patients under clozapine treatment., PMID:40081291
Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor., PMID:40076408
CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway., PMID:40069491
Insights into CdTe quantum dots induced hepatotoxicity: Regulation of cytochromes P450 isoenzymes function in liver microsomes from in vivo and in vitro studies., PMID:40044020
Geometry-encoded molecular dynamics enables deep learning insights into P450 regiospecificity control., PMID:40032954
Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review., PMID:40029540
[Application of Human Liver Organoids for Pharmaceutical Research]., PMID:40024731
Evaluation of reversible cytochrome P450 inhibition by Withania somnifera leaf and root extracts., PMID:40023576
Cannabidiol and Δ9-tetrahydrocannabinol induce drug-metabolizing enzymes, but not transporters, in human hepatocytes: Implications for predicting complex cannabinoid-drug interactions., PMID:40009936
Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver., PMID:39997363
A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil., PMID:39982209
Toxicokinetics and analytical toxicology of the phenmetrazine-derived new psychoactive substance 3,4-methylenedioxyphenmetrazine studied by means of in vitro systems., PMID:39903277
The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [14C]Binimetinib 45 mg in Healthy Male Participants., PMID:39887964
Clinical Evaluation of Drug-Drug Interactions with Obeldesivir, an Orally Administered Antiviral Agent., PMID:39887351
Metabolic effects of heterocyclic amines on insulin‑induced AKT phosphorylation and gluconeogenic gene expression are modified by N -acetyltransferase 2 genetic polymorphism., PMID:39878101
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway., PMID:39870009
Deep Learning of CYP450 Binding of Small Molecules by Quantum Information., PMID:39869197
Sex-specific impacts of caffeine on body composition: commentary on a retrospective cohort study., PMID:39825466
Post-COVID metabolic enzyme alterations in K18-hACE2 mice exacerbate alcohol-induced liver injury through transcriptional regulation., PMID:39798903
Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes., PMID:39793773
The refined CYP2B6-Template system for studies of its ligand metabolisms., PMID:39793292
Bioactivation, Mutagenicity, DNA Damage, and Oxidative Stress Induced by 3,4-Dimethylaniline., PMID:39766269
Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity., PMID:39755645
For research use only. Not for human or drug use.
