Catalog No.
YHC13101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly124-Leu363
Predicted molecular weight
53.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05107
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837
LDL receptor-mediated endocytosis of Escherichia coli α-hemolysin mediates renal epithelial toxicity., PMID:40504153
Rare Hemoglobin Variant Hb Handsworth (HBA1:c.55 G>C): Leads to False Positive Diagnosis of Hb S., PMID:40497600
CD151 interacts with integrin beta 2 in B cell lymphomas., PMID:40464949
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574
Molecular basis of β2 integrin activation by talin unveils subunit-specific mechanisms of integrin signaling., PMID:40310722
Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1., PMID:40305711
CTSL-2 upon specifically recognizing Vibrio splendidus directly cleaves complement C3 to promote the bacterial phagocytosis and degradation in oyster., PMID:40275325
ICAM-1/CD18-mediated sequestration of parasitized phagocytes in cortical capillaries promotes neuronal colonization by Toxoplasma gondii., PMID:40229286
ITGB2 and ICAM3 predict increased survival of sepsis with decreased intercellular communication in cytotoxic CD8+ T cells., PMID:40221459
Phillyrin counters β2 integrin-mediated neutrophil adhesion and chemotaxis to alleviate endotoxin-induced acute lung injury in neonatal rats., PMID:40210127
A novel ITGB2 variant in a patient with severe recurrent pyoderma gangrenosum-like lesions and underlying leukocyte adhesion deficiency type I: case report and literature review., PMID:40195196
Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression., PMID:40187756
Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice., PMID:40186763
Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages., PMID:40105369
Multifaceted, unique role of CD11c in leukocyte biology., PMID:40103815
Determining Ligand Binding and Specificity Within the β2-Integrin Family with a Novel Assay Platform., PMID:40001541
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2., PMID:39938515
β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury., PMID:39923080
GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18., PMID:39899622
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1., PMID:39883854
Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation., PMID:39867459
Musa paradisiaca L. Inflorescence Abrogates Neutrophil Activation by Downregulating TLR4/NF-KB Signaling Pathway in LPS-Induced Acute Lung Injury Model., PMID:39861071
Force-bearing phagocytic adhesion rings mediate the phagocytosis of surface-bound particles., PMID:39856073
Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant for leukocyte adhesion deficiency with graft failure: a case report., PMID:39845947
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro., PMID:39795170
The influence of probiotic administration on selected leukocyte subpopulations and the serum amyloid A concentration in the peripheral blood of dairy cows during different lactation periods., PMID:39776688
Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1., PMID:39773732
The Integrin Receptors: From Discovery to Structure to Medicines., PMID:39724488
Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases., PMID:39603636
Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke., PMID:39601147
Influence of exposure duration on human pressure-induced inflammatory responses: Comparison between tunnel workers and underwater divers., PMID:39567182
Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization., PMID:39549815
Integrin β2 regulates titanium particle‑induced inflammation in macrophages: In vitro aseptic loosening model., PMID:39540364
Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene., PMID:39522300
Serum integrin accumulation during asthma exacerbation: The role of matrix metalloproteinases., PMID:39511761
Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages., PMID:39503081
β2-integrins control HIF1α activation in human neutrophils., PMID:39469705
Ablation of the Integrin CD11b Mac-1 Limits Deleterious Responses to Traumatic Spinal Cord Injury and Improves Functional Recovery in Mice., PMID:39329765
β2 integrins impose a mechanical checkpoint on macrophage phagocytosis., PMID:39294148
C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via β2-Integrins., PMID:39273598
GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients., PMID:39253088
Monitoring Circulating Myeloid Cells in Peritonitis with an In Vivo Imaging Flow Cytometer., PMID:39199274
Integrative analysis of single-Cell RNA sequencing and experimental validation in the study of abdominal aortic aneurysm progression., PMID:39103059
ITGB2 related to immune cell infiltration as a potential therapeutic target of inflammatory bowel disease using bioinformatics and functional research., PMID:39088353
Sweet syndrome associated with moderate leukocyte adhesion deficiency type I: a case report and review of the literature., PMID:39081307
Postmortem Immunohistochemical Findings in Early Acute Myocardial Infarction: A Systematic Review., PMID:39062865
For research use only. Not for human or drug use.
