Catalog No.
VHV22901
Species reactivity
Human metapneumovirus (strain CAN97-83) (HMPV)
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Target
Fusion glycoprotein F0, Protein F, Fusion glycoprotein F2, Fusion glycoprotein F1
Concentration
1.7 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q6WB98
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
100 mM Pro-Ac, 20 mM Arg, pH 5.0
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
MPV467
A Computationally Designed Prefusion Stabilized Human Metapneumovirus Fusion Protein Vaccine Antigen Elicited a Potent Neutralization Response., PMID:40432132
Robust Multiepitope Vaccine from Glycoproteins Against Human Metapneumovirus Genotypes A2a, A2b, and A2c by Utilizing Immunoinformatics and Reverse Vaccinology Approaches., PMID:40401430
Virus-specific CD4+ T cells contribute to clearance of human metapneumovirus despite exhibiting an impaired phenotype., PMID:40365919
Clinical Insights and Advancements in Human Metapneumovirus Management and Prognosis., PMID:40351504
Human Metapneumovirus: A Comprehensive Epidemiological Analysis of a Global Respiratory Threat., PMID:40343424
Impact of Nirsevimab on RSV and Non-RSV Severe Respiratory Infections in Hospitalized Infants., PMID:40302169
Development of Standard and Rapid Antigen Detection Assays for Human Metapneumovirus., PMID:40297986
A Randomized Phase 1 Clinical Trial of a Respiratory Syncytial Virus and Human Metapneumovirus Combination Protein-Based Virus-like Particle Vaccine in Adults 60-75 Years of Age., PMID:40201719
Human Metapneumovirus Seasonality and Co-Circulation with Respiratory Syncytial Virus - United States, 2014-2024., PMID:40179043
Insights in the RSV L polymerase function and structure., PMID:40127873
A tumor-binding antibody with cross-reactivity to viral antigens., PMID:40009215
Type I Interferon Targets Alveolar Macrophages to Promote Bacterial Pneumonia after Viral Infection., PMID:39879546
Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro., PMID:39776441
Clinical outcomes and severity of laboratory-confirmed RSV compared with influenza, parainfluenza and human metapneumovirus in Australian children attending secondary care., PMID:39694679
A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein., PMID:39554078
Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus., PMID:39550381
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer., PMID:39054318
Human monoclonal antibodies protect against viral-mediated pneumococcal superinfection., PMID:38933273
Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice., PMID:38898106
Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children., PMID:38738290
VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice., PMID:38641492
Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study., PMID:38529669
A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimers., PMID:38496645
A robust, scalable, and cost-efficient approach to whole genome sequencing of RSV directly from clinical samples., PMID:38407068
Human metapneumovirus respiratory infection affects both innate and adaptive intestinal immunity., PMID:38404579
A general computational design strategy for stabilizing viral class I fusion proteins., PMID:38351001
Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis., PMID:38315735
A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein., PMID:38117059
Structural characterization of M8C10, a neutralizing antibody targeting a highly conserved prefusion-specific epitope on the metapneumovirus fusion trimerization interface., PMID:38032197
Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus., PMID:37738240
Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice., PMID:37657510
Structural basis for respiratory syncytial virus and human metapneumovirus neutralization., PMID:37544710
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection., PMID:37528458
Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode., PMID:37516111
Neutralising antibodies against human metapneumovirus., PMID:37499668
[Distribution of non-bacterial pathogens in 1 788 children with community-acquired pneumonia]., PMID:37382134
The HRA2pl fusion peptide exerts in vitro antiviral activity against human respiratory paramyxoviruses and pneumoviruses., PMID:37153148
A general computational design strategy for stabilizing viral class I fusion proteins., PMID:36993551
Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus., PMID:36851691
Cross-protective antibodies against common endemic respiratory viruses., PMID:36781872
A Candidate Therapeutic Monoclonal Antibody Inhibits Both HRSV and HMPV Replication in Mice., PMID:36289776
Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses - New Vaccine Surveillance Network, United States, 2016-2021., PMID:36201373
Impact of the COVID-19 pandemic on influenza and respiratory syncytial virus antibody titres in the community: a prospective cohort study in Neustadt, Thuringia, Germany., PMID:36180083
Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus., PMID:36130517
A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein., PMID:36003370
Role of human metapneumovirus glycoprotein G in modulation of immune responses., PMID:35958551
Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein., PMID:35944529
First Case of Acute Myocarditis Caused by Metapneumovirus in an Immunocompromised 14-year-old Girl., PMID:35836619
Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults., PMID:35794943
Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine., PMID:35731888
For research use only. Not for human or drug use.
