Catalog No.
YHB95501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser113-Ala271
Predicted molecular weight
19.2 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P01583
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
Causal relationship between 91 circulating inflammatory proteins and gynecological diseases: A two-sample bidirectional Mendelian randomization study., PMID:40441565
In Vitro, Ex Vivo, Instrumental, and Clinical Assessment of a Novel Anti-aging Serum Targeting Oxidative Stress., PMID:40178310
Study of the relationship between the level of proinflammatory cytokines and β2-microglobulin with indicators of changes in the functional status of the kidneys in diabetic nepropathy to determine the degrees of chronic renal failure., PMID:40125738
Mitochondrial ROS connects P2X7-mediated Ca2+ influx with IL-1α release by monocytes upon chronic tissue damage., PMID:39984250
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment., PMID:39803956
The relationship of irisin, apelin-13, and immunological markers il-1α & amp, il-1β with diabetes in kidney failure patients., PMID:39799489
Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity., PMID:39577420
Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in chronic kidney disease in a reactive oxygen species-dependent manner., PMID:39571908
Aura and osmophobia are associated with the IL1A -889C > T (rs1800587) variant in migraine., PMID:39505006
The interleukin-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via the intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1., PMID:39482861
Assessing the causal relationship between CRP, IL-1α, IL-1β, and IL-6 levels and intervertebral disc degeneration: a two-sample Mendelian randomization study., PMID:39390000
Intervertebral disc degenerative disease in South Africa: a case-control analysis of selected gene variants., PMID:39287911
Association between IL-6 -174 G/C (rs1800795) and IL-1A -889 C/T (rs1800587) cytokine variants with polycystic ovary syndrome in Iranian women: A case-control study., PMID:39222755
Interleukin-1α inhibitor bermekimab in patients with atopic dermatitis: randomized and nonrandomized studies., PMID:39214920
Skin inflammatory signatures, as measured by disordered spatial redness patterns, predict current and future skin ageing attributes., PMID:39171635
Cord blood cytokine profiles in children later diagnosed with autism spectrum disorder: Results from the prospective MARBLES study., PMID:39163910
Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair., PMID:39147560
IRF1 and IL1A associated with PANoptosis serve as potential immune signatures for lung ischemia reperfusion injury following lung transplantation., PMID:39074415
Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors., PMID:38904694
Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line., PMID:38799687
Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis., PMID:38723369
Interleukin-1α links peripheral CaV2.2 channel activation to rapid adaptive increases in heat sensitivity in skin., PMID:38643253
Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients., PMID:38513309
GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes., PMID:38393364
Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells., PMID:38225348
IL1A regulates the inflammation in gout through the Toll-like receptors pathway., PMID:38164346
IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α., PMID:37998338
Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis., PMID:37701434
Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production., PMID:37309666
Gene deletion of Interleukin-1α reduces ER stress-induced CHOP expression in macrophages and attenuates the progression of atherosclerosis in apoE-deficient mice., PMID:37146542
IL-1α/β and IL-18 profiles and their impact on claudin-1, loricrin and filaggrin expression in patients with atopic dermatitis., PMID:37114373
Xeno-free cultured mesenchymal stromal cells release extracellular vesicles with a "therapeutic" miRNA cargo ameliorating cartilage inflammation in vitro., PMID:37056573
Transcriptomic Analysis from Normal Glucose Tolerance to T2D of Obese Individuals Using Bioinformatic Tools., PMID:37047308
Interleukin 1α and interleukin 18 in patients with vitiligo - Results of a case-control study., PMID:36739764
Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren's syndrome., PMID:36627528
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses., PMID:36591308
Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression., PMID:36505497
Oropharyngeal tumor cells induce COX-2 expression in peripheral blood monocytes by secretion of IL-1α., PMID:36426368
Gene locus polymorphisms and expression levels of interleukin-1 in lumbar disc disease: A MOOSE-compliant meta-analysis and immunohistochemical study., PMID:36316862
The Association of Inflammatory Markers, IL-1α and TGF-β, with Dietary Insulin Load and Dietary Insulin Index in Overweight and Obese Women with Healthy and Unhealthy Metabolic Phenotypes: A Cross-Sectional Study., PMID:36311488
The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury., PMID:36184639
The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin-1α release from human blood cells., PMID:36175368
Analysis of Chitinase-3-Like Protein 1, IL-1-Alpha, and IL-6 as Novel Inflammatory Biomarkers for COVID-19., PMID:35960307
Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media., PMID:35878246
Association between IL-1A and IL-1B gene polymorphisms with peri-implantitis in a Portuguese population-a pilot study., PMID:35855430
SOX9 and IL1A as the Potential Gene Biomarkers of the Oral Cancer., PMID:35762542
Genome-wide association study of primary dysmenorrhea in the Taiwan Biobank validates associations near the NGF and IL1 gene loci., PMID:35351958
Paclitaxel-Induced Epidermal Alterations: An In Vitro Preclinical Assessment in Primary Keratinocytes and in a 3D Epidermis Model., PMID:35163066
The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters., PMID:35139823
The impact of extractable organic matter from gasoline and alternative fuel emissions on bronchial cell models (BEAS-2B, MucilAir™)., PMID:35066112
For research use only. Not for human or drug use.
