Catalog No.
PHA41501
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SMAD7 (Met1-Arg426).
Target
Mothers against decapentaplegic homolog 8, MADH8, SMAD family member 7, MADH7, SMAD 7, Mothers against decapentaplegic homolog 7, Smad7, hSMAD7, Mothers against DPP homolog 7, SMAD7, Mothers against DPP homolog 8, MAD homolog 8, MAD homolog 7
Purification
Antigen affinity purification.
Accession
O15105
Applications
ELISA, IHC, IF, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
[Effect of Buzhong Yiqi Decoction on Treg cells in rats with autoimmune thyroiditis through TGF-β/Smad signaling pathway]., PMID:39701767
[The Role of TGF-β1/SMAD in Diabetic Nephropathy: Mechanisms and Research Development]., PMID:38162063
TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease., PMID:37908840
Changes in the Expression of TGF-Beta Regulatory Pathway Genes Induced by Vitamin D in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:37833895
Diagnostic value of anti-integrin αvβ6 antibodies in ulcerative colitis., PMID:37407314
Overexpression of SMAD7 improves the function of EGFR-targeted human CAR-T cells against non-small-cell lung cancer., PMID:37376985
Localised Delivery of Macromolecules to the Large Intestine: Translation to Clinical Trials., PMID:36282433
Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7‑TGF‑β pathway in allergic rhinitis., PMID:35029288
Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells., PMID:34847881
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7., PMID:34061176
Treatment with phosphodiester CpG-ODN ameliorates atopic dermatitis by enhancing TGF-β signaling., PMID:33612150
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities., PMID:33480423
IFNβ signaling inhibits osteogenesis in human SLE bone marrow., PMID:32515653
Gene Signatures of Early Response to Anti-TNF Drugs in Pediatric Inflammatory Bowel Disease., PMID:32397546
TGF-β activity restoration and phosphodiesterase 4 inhibition as therapeutic options for inflammatory bowel diseases., PMID:32194176
EZH2 deficiency attenuates Treg differentiation in rheumatoid arthritis., PMID:31952907
Oligonucleotides-A Novel Promising Therapeutic Option for IBD., PMID:31068803
KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27., PMID:30786277
Effects of Clematis chinensis Osbeck mediated by low-intensity pulsed ultrasound on transforming growth factor-β/Smad signaling in rabbit articular chondrocytes., PMID:30659392
lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p., PMID:30556161
Ghrelin attenuates myocardial fibrosis after acute myocardial infarction via inhibiting endothelial-to mesenchymal transition in rat model., PMID:30218693
Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model., PMID:30185419
Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise., PMID:30137309
Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1., PMID:30130141
Calcimycin Suppresses S100A4 Expression and Inhibits the Stimulatory Effect of Transforming Growth Factor β1 on Keloid Fibroblasts., PMID:29846215
Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer., PMID:29610597
Novel treatments for inflammatory bowel disease., PMID:29223139
The Expanding Therapeutic Armamentarium for Inflammatory Bowel Disease: How to Choose the Right Drug[s] for Our Patients?, PMID:28961959
Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast., PMID:28864007
Effects of the combined extracts of Herba Epimedii and Fructus Ligustrilucidi on airway remodeling in the asthmatic rats with the treatment of budesonide., PMID:28764781
Frontiers in Drug Research and Development for Inflammatory Bowel Disease., PMID:28690543
New treatment strategies for ulcerative colitis., PMID:28617055
Resolution of inflammation in inflammatory bowel disease., PMID:28606878
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5., PMID:28489883
Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics., PMID:28486793
Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels., PMID:28418194
Inflammatory Bowel Disease: New Therapeutic Options in the Post Anti-TNFα Era., PMID:28382862
Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-β1/Smads Signal Transduction Pathway in IgA Nephropathy., PMID:28208683
Current and emerging therapeutic targets for IBD., PMID:28144028
Novel Targeted Therapies for Inflammatory Bowel Disease., PMID:27916280
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases., PMID:27780712
miR-21 promotes collagen production in keloid via Smad7., PMID:27717618
Recent insights into the molecular pathogenesis of Crohn's disease: a review of emerging therapeutic targets., PMID:27042137
Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling., PMID:26919280
Mesenchymal stem cells promote tumor angiogenesis via the action of transforming growth factor β1., PMID:26893697
Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer., PMID:26567849
The role of chronic inflammation in the development of gastrointestinal cancers: reviewing cancer prevention with natural anti-inflammatory intervention., PMID:26524133
[Treatment of inflammatory bowel diseases]., PMID:26520192
Therapeutic innovations in inflammatory bowel diseases., PMID:26509246
Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling., PMID:26446848
For research use only. Not for human or drug use.
