Catalog No.
EHC35102
Expression system
Mammalian cells
Species
Homo sapiens (Human)
Protein length
[Met1-Asp728] & [Met1-Tyr995]
Predicted molecular weight
86.86 kDa & 109.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05556 & P08648
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MSK12, VLA-4 subunit beta, CD29, Integrin beta-1, ITGB1, FNRB, MDF2, GPIIA, Glycoprotein IIa, Fibronectin receptor subunit beta, CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation., PMID:40501821
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties., PMID:40489013
Age-Related Dysregulation of α5β1 and αvβ3 Integrin Activity Alters Contractile Properties of Trabecular Meshwork Cells., PMID:40488712
Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB α5β1, especially in patients with high expression of ACPA., PMID:40480022
Interaction of Serratia proteamaculans with Integrins Activates Invasion-Promoting Signaling Pathways., PMID:40362195
Structural and Functional Differences of Rhodostomin and Echistatin in Integrin Recognition and Biological Implications., PMID:40318183
Fibroblast Activation Protein (FAP)+ cancer-associated fibroblasts induce macrophage M2-like polarization via the Fibronectin 1-Integrin α5β1 axis in breast cancer., PMID:40263422
Spatial regulation of mitochondrial membrane potential by α5β1 integrin engagement in collective cell migration., PMID:40223421
Rapid and Inexpensive Image-Guided Grayscale Biomaterial Customization via LCD Printing., PMID:40145385
Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells., PMID:40126508
Loss of Tyrosine Phosphatase Mu Promotes Scoliosis Progression Through Osteopontin-α5β1 Integrin Signaling and PIPK1γ90 Activity., PMID:39940812
Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands., PMID:39908297
Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts., PMID:39866379
Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights From Comprehensive Multicenter Preclinical Studies., PMID:39829438
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer., PMID:39815258
Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts., PMID:39785683
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression., PMID:39779823
SPP1-ITGα5/β1 Accelerates Calcification of Nucleus Pulposus Cells by Inhibiting Mitophagy via Ubiquitin-Dependent PINK1/PARKIN Pathway Blockade., PMID:39721032
The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3., PMID:39713860
O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner., PMID:39671515
Endothelial Angpt2 Promotes Adipocyte Progenitor Cells Maturation to Increase Visceral Adipose Tissue Accumulation., PMID:39628006
A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules., PMID:39591241
An in-silico study reveals that a C-terminal fragment of the adhesion protein Fibulin7 (Fbln7-C) regulates the activation of integrin α5β1 through dynamics of VWA and the hybrid domain in the β1 subunit., PMID:39578974
Dual-Integrin-Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy., PMID:39573882
FNDC1 is a myokine that promotes myogenesis and muscle regeneration., PMID:39567831
Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart., PMID:39554004
Integrin Subtypes and Lamellipodia Mediate Spatial Sensing of RGD Ligands during Cell Adhesion., PMID:39546750
Intercellular junction-driven stromal cell stacking in a confined 3D microcavity., PMID:39525363
Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells., PMID:39430758
Machine Learning Classification of Integrin-Expression-Based Magnetic Sorted SW 620 Cells by Simultaneous O-PTIR and SERS., PMID:39412786
Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts., PMID:39412594
Innovative nebulization delivery of lipid nanoparticle-encapsulated siRNA: a therapeutic advance for Staphylococcus aureus-induced pneumonia., PMID:39407291
Fibroblast integrin α11β1 is a collagen assembly receptor in mechanoregulated fibrillar adhesions., PMID:39406317
Skin organoid transplantation promotes tissue repair with scarless in frostbite., PMID:39363875
Elucidating the unexpected cell adhesive properties of agarose substrates. The effect of mechanics, fetal bovine serum and specific peptide sequences., PMID:39357634
Exploration into Galectin-3 Driven Endocytosis and Lattices., PMID:39334935
Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumor., PMID:39330703
Exploring the potential role of palladin in modulating human CAF/ECM functional units., PMID:39239855
Integrin A5B1-mediated endocytosis of polystyrene nanoplastics: Implications for human lung disease and therapeutic targets., PMID:39236815
Unraveling the molecular basis for effective regulation of integrin α5β1 for enhanced therapeutic interventions., PMID:39236588
m6A-Dependent ITIH1 Regulated by TGF-β Acts as a Target for Hepatocellular Carcinoma Progression., PMID:39234824
Phosphorylated vimentin-triggered fibronectin matrix disaggregation enhances the dissemination of Treponema pallidum subsp. pallidum across the microvascular endothelial barrier., PMID:39226326
The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3., PMID:39149327
Icariin promotes cell adhesion for osteogenesis in bone marrow stromal cells via binding to integrin α5β1., PMID:39067311
Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infection., PMID:39026703
Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrins., PMID:39002689
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine., PMID:38979380
Disintegrin Accutin inhibits A549 cell migration though suppression of EMT and FAK/AKT signaling pathway., PMID:38971284
Sulfonamide-chalcone hybrid compound suppresses cellular adhesion and migration: Experimental and computational insight., PMID:38908811
Interactions of Cardiac Proteins with Plasma-Synthesized Polypyrrole (PSPy) to Improve Adult Cardiomyocytes Culture., PMID:38891417
For research use only. Not for human or drug use.
