Catalog No.
YHB63001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn299-Ser407
Predicted molecular weight
13.7 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95390
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11
Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control., PMID:40481031
GDF11 Alleviates Vascular Calcification in VitD3-Overloaded Mice Through Inhibition of Inflammatory NF-κB Signal., PMID:40432427
Effects of porang glucomannan combined with a high-protein diet on oxidative stress, inflammation, and aging markers in D-galactose-induced rats., PMID:40352180
The influence of the geroprotective cytokine on the transcriptome of young and senescent mesenchymal stem cells., PMID:40275319
Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators., PMID:40102566
GDF11 Regulates M1 and M2 Polarization of BV2 Microglial Cells via p38 MAPK Signaling Pathway., PMID:40100492
gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling., PMID:40055488
Targeting the TGF-β-p21 axis: a critical regulator of bleomycin-induced cell cycle arrest and apoptosis in vitro-implication for progressive cervical cancer therapy., PMID:40019671
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis., PMID:39961488
GDF11 Mitigates Neuropathic Pain via Regulation of Microglial Polarization and Neuroinflammation through TGF-βR1/SMAD2/NF-κB Pathway in Male Mice., PMID:39939465
Recombinant GDF11 Promotes Recovery in a Rat Permanent Ischemia Model of Subacute Stroke., PMID:39909827
Myokines: metabolic regulation in obesity and type 2 diabetes., PMID:39872377
Sotatercept in pulmonary hypertension and beyond., PMID:39825683
Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos., PMID:39702818
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates., PMID:39668251
Sevoflurane Activates PI3K/AKT Signaling Pathway by Upregulating GDF11 Expression to Attenuate Ischemia/Reperfusion Injury in Cardiomyocytes., PMID:39463227
Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial., PMID:39437803
Growth differentiation factor 11 alleviates oxidative stress-induced senescence of endothelial progenitor cells via activating autophagy., PMID:39420391
Gdf11 regulates left-right asymmetry development through TGF-β signal., PMID:39407407
GDF11 promotes osteogenic/odontogenic differentiation of dental pulp stem cells to accelerate dentin restoration via modulating SIRT3/FOXO3-mediated mitophagy., PMID:39317051
Pathomechanisms of Monoallelic variants in TTN causing skeletal muscle disease., PMID:39277846
Evolution and Comparative Genomics of the Transforming Growth Factor-β-Related Proteins in Nile Tilapia., PMID:39240458
Novel insights into the pleiotropic health effects of growth differentiation factor 11 gained from genome-wide association studies in population biobanks., PMID:39237910
Therapeutic targeting of GDF11 in muscle atrophy: Insights and strategies., PMID:39236952
Identification of key module and hub genes affecting broiler body weight through weighted gene co-expression network analysis., PMID:39153266
Growth Differentiation Factor 11 Evokes Lung Injury, Inflammation, and Fibrosis in Mice through the Activin A Receptor Type II-Like Kinase, 53kDa-Smad2/3 Signaling Pathway., PMID:39147236
Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro., PMID:39134286
GDF11 (Protein of Juvenility) and GDF15 (Protein of Senility) in the Plasma of Patients with Sleep Apnea Syndrome: a Pilot Study., PMID:39090465
Expression profiling by high-throughput sequencing reveals GADD45, SMAD7, EGR-1 and HOXA3 activation in Myostatin (MSTN) and GDF11 treated myoblasts., PMID:39012095
Liraglutide reduces bone marrow adipogenesis by miR-150-5p/ GDF11 axis in diabetic rats., PMID:38960061
GDF-15 Attenuates the Epithelium-Mesenchymal Transition and Alleviates TGFβ2-Induced Lens Opacity., PMID:38949633
GDF11 OVEREXPRESSION ALLEVIATES SEPSIS-INDUCED LUNG MICROVASCULAR ENDOTHELIAL BARRIER DAMAGE BY ACTIVATING SIRT1/NOX4 SIGNALING TO INHIBIT FERROPTOSIS., PMID:38920138
GDF11 improves hippocampal neurogenesis and cognitive abilities in diabetic mice by reducing neural inflammation., PMID:38777287
Growth differentiation factor 11 regulates high glucose-induced cardiomyocyte pyroptosis and diabetic cardiomyopathy by inhibiting inflammasome activation., PMID:38715043
Inhibition of activin receptor 2 signalling ameliorates metabolic dysfunction-associated steatotic liver disease in western diet/L-NAME induced cardiometabolic disease., PMID:38705130
Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke., PMID:38650680
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping., PMID:38618242
Tissue Expression of Growth Differentiation Factor 11 in Patients with Breast Cancer., PMID:38611614
The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia., PMID:38604437
Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7., PMID:38533769
[Correlation between serum growth differentiation factor 11 level and severity of coronary artery disease in patients with acute myocardial infarction]., PMID:38514331
GDF11: An emerging therapeutic target for liver diseases and fibrosis., PMID:38494851
GDF11 level and its effect on prognosis in patients with acute myeloid leukemia., PMID:38415361
Progress in the relationship between GDF11 and depression., PMID:38378101
Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells., PMID:38369181
GDF11 and aging biology - controversies resolved and pending., PMID:38235060
GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway., PMID:38182060
Growth differentiation factor 11 suppresses intrahepatic inflammation via restricting NLRP3 inflammasome activation in LPS-induced liver injury., PMID:38158658
The regulatory effect of growth differentiation factor 11 on different cells., PMID:38143761
For research use only. Not for human or drug use.
