Catalog No.
YHA27801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser31-Phe350
Predicted molecular weight
38.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14727
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APAF1, APAF-1, Apoptotic protease-activating factor 1, KIAA0413
Computational Characterization of the Interaction of CARD Domains in the Apoptosome., PMID:39761026
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression., PMID:39627554
Optimization of a novel expression system for recombinant protein production in CHO cells., PMID:39438721
Association between NKILA and some apoptotic gene expression in atherosclerosis., PMID:39184397
LC-MS based metabonomics study on protective mechanism of ESWW in cerebral ischemia via CYTC/Apaf-1/NDRG4 pathway., PMID:38657364
Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1., PMID:38348717
Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease., PMID:37108258
Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats., PMID:37009805
Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma., PMID:36351409
APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly., PMID:35975461
LncRNA UCA1 epigenetically suppresses APAF1 expression to mediate the protective effect of sevoflurane against myocardial ischemia-reperfusion injury., PMID:35723795
The effects of temperature variation treatments on embryonic development: a mouse study., PMID:35169175
Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis., PMID:35030371
Exosomal microRNA⁃93⁃3p secreted by bone marrow mesenchymal stem cells downregulates apoptotic peptidase activating factor 1 to promote wound healing., PMID:34898374
Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy., PMID:34830349
Immunohistochemical Markers of Apoptotic and Hypoxic Damage Facilitate Evidence-Based Assessment in Pups with Neurological Disorders., PMID:34679033
Apaf1 nanoLuc biosensors identified lentinan as a potent synergizer of cisplatin in targeting hepatocellular carcinoma cells., PMID:34507064
PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway., PMID:34304702
Contribution of Apaf-1 to the pathogenesis of cancer and neurodegenerative diseases., PMID:34298080
Methylation of Promoters of Apoptosis-Related Genes in Blood Lymphocytes of Workers Exposed to Occupational External Irradiation., PMID:34297287
Upregulation of apoptotic protease activating factor-1 expression correlates with anti-tumor effect of taxane drug., PMID:34181104
Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss., PMID:33931965
Treating MCF7 breast cancer cell with proteasome inhibitor Bortezomib restores apoptotic factors and sensitizes cell to Docetaxel., PMID:33904968
Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis., PMID:33386492
Hepatitis B virus surface protein induces sperm dysfunction through the activation of a Bcl2/Bax signaling cascade triggering AIF/Endo G-mediated apoptosis., PMID:33382193
Melittin suppresses growth and induces apoptosis of non-small-cell lung cancer cells via down-regulation of TGF-β-mediated ERK signal pathway., PMID:33331417
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition., PMID:33308446
EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis., PMID:33177505
Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9., PMID:33132160
Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure., PMID:32979334
Long Noncoding RNA Hypoxia-Inducible Factor-1 Alpha-Antisense RNA 1 Regulates Vascular Smooth Muscle Cells to Promote the Development of Thoracic Aortic Aneurysm by Modulating Apoptotic Protease-Activating Factor 1 and Targeting let-7g., PMID:32653692
Epigenetic Regulation of APAF-1 Through DNA Methylation in Pancreatic Cancer., PMID:32620616
Ribosomal protein S11 influences glioma response to TOP2 poisons., PMID:32528131
Mechanism of Heshouwuyin inhibiting the Cyt c/Apaf-1/Caspase-9/Caspase-3 pathway in spermatogenic cell apoptosis., PMID:32527252
The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway., PMID:32461338
Anticancer and antimetastatic activity of Hypomyces chrysospermus, a cosmopolitan parasite in different human cancer cells., PMID:32378168
Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts., PMID:32366831
Gonadotrophins modulate cell death-related genes expression in human endometrium., PMID:32304301
Taurine attenuates isoproterenol-induced H9c2 cardiomyocytes hypertrophy by improving antioxidative ability and inhibiting calpain-1-mediated apoptosis., PMID:32304004
Optimization of Experimental Variables Influencing Apoptosome Biosensor in HEK293T Cells., PMID:32210205
Hypoxia-induced up-regulation of miR-27a promotes paclitaxel resistance in ovarian cancer., PMID:32190895
Zinc oxide nanoparticles induce human tenon fibroblast apoptosis through reactive oxygen species and caspase signaling pathway., PMID:32112740
Propolis prevents inhibition of apoptosis by potassium bromate in CCD 841 human colon cell., PMID:31990996
System of Markers Based on the Methylation of a Group of Proapoptotic Genes in Combination with MicroRNA in the Diagnosis of Breast Cancer., PMID:31938917
Cytotoxicity, Cell Adhesion, and Apoptotic Gene Expression in Periodontal Ligament Fibroblasts treated with Endodontic Sealers., PMID:31935309
Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs., PMID:31911497
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis., PMID:31818185
Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer., PMID:31678591
Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis., PMID:31664306
EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation., PMID:31498791
For research use only. Not for human or drug use.
