Catalog No.
YHA25401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu78-Thr250
Predicted molecular weight
21.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14641
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dishevelled-2, DVL2, DSH homolog 2, Segment polarity protein dishevelled homolog DVL-2
LRRFIP1 enhances the Wnt/β-catenin pathway by binding to DVLs in myelodysplastic syndrome., PMID:40420163
Ishophloroglucin A Isolated From Ishige okamurae Stimulates Osteoblast Differentiation Through Activation of the Bone Morphogenetic Protein and Wnt/β-Catenin Signaling Pathways in MC3T3-E1 Cells., PMID:40343669
TFE3-rearranged ossifying fibromyxoid tumors are uniquely negative for glycoprotein non-metastatic melanoma protein B: A study of 13 TFE3-rearranged mesenchymal tumors., PMID:40189028
Aptamer inhibits P-glycoprotein efflux function via the Wnt/β-catenin signaling pathway., PMID:40168709
Eurycomalactone switched hepatocellular carcinoma cells into quiescence through 5'tRFAla/DVL/β-catenin pathway inhibition., PMID:40128187
Functional Evaluation of Neural Tube Defect-Related Missense Mutations Using In Silico Methods., PMID:39950581
SENP2 as a critical regulator in liver ischemia-reperfusion injury., PMID:39890015
Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways., PMID:39812109
Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling., PMID:39652469
Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury., PMID:39644526
GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification., PMID:39560901
Exploring DIX-DIX Homo- and Hetero-Oligomers in Wnt Signaling with AlphaFold2., PMID:39404409
Autophagy controls neuronal differentiation by regulating the WNT-DVL signaling pathway., PMID:39385328
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP., PMID:39366759
Intracellular Construction of Organelle-like Compartments Facilitates Metabolic Flux in Escherichia coli., PMID:39230507
Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation., PMID:39223191
[Lycium barbarum miR2911-loaded exosomes promote spermatogenic function recovery in rats with non-obstructive azoospermia by regulating Wnt/β-catenin signaling pathways]., PMID:39212356
ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2., PMID:39210030
Wnt7b acts in concert with Wnt5a to regulate tissue elongation and planar cell polarity via noncanonical Wnt signaling., PMID:39172791
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
The upregulation of POLR3G correlates with increased malignancy of bladder urothelium., PMID:39039528
Iloperidone and Temozolomide Synergistically Inhibit Growth, Migration and Enhance Apoptosis in Glioblastoma Cells., PMID:38927341
The dishevelled associated activator of morphogenesis protein 2 (Daam2) regulates neural tube closure., PMID:38877839
Dishevelled localization and function are differentially regulated by structurally distinct sterols., PMID:38798572
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF., PMID:38714795
RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma., PMID:38576051
Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations., PMID:38558095
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis., PMID:38433252
Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p., PMID:38365722
Properties of biomolecular condensates defined by Activator of G-protein Signaling 3., PMID:38264908
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model., PMID:38041203
Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration., PMID:37830616
HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34+ hematopoietic progenitor cells., PMID:37772824
Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression., PMID:37703992
Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression., PMID:37534375
ASPM overexpression enhances cellular proliferation and migration and predicts worse prognosis for papillary renal cell carcinoma., PMID:37309171
Dishevelled segment polarity protein 2 promotes gastric cancer progression through Wnt/β-catenin pathway., PMID:37257286
Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer., PMID:37138492
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction., PMID:37014927
Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer., PMID:36809986
Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori., PMID:36720664
Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling., PMID:36398662
Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin., PMID:36383195
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism., PMID:36357669
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly., PMID:36342472
Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis., PMID:36323918
Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2., PMID:36066768
High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis., PMID:35971121
DYNLT3 overexpression induces apoptosis and inhibits cell growth and migration via inhibition of the Wnt pathway and EMT in cervical cancer., PMID:35965516
Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates., PMID:35867833
For research use only. Not for human or drug use.
