Catalog No.
YHA20701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser115
Predicted molecular weight
39.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14519
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deleted in oral cancer 1, CDK2-associated protein 1, DOC-1, CDKAP1, Putative oral cancer suppressor, CDK2AP1, DOC1, Cyclin-dependent kinase 2-associated protein 1
Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer., PMID:39113208
Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells., PMID:37958905
The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs., PMID:37217493
Consistent DNA Hypomethylations in Prostate Cancer., PMID:36613831
The Association between Cyclin Dependent Kinase 2 Associated Protein 1 (CDK2AP1) and Molecular Subtypes of Lethal Prostate Cancer., PMID:36362115
CDK2AP1 influences immune infiltrates and serves as a prognostic indicator for hepatocellular carcinoma., PMID:36105112
A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development., PMID:34644528
Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1., PMID:34589742
Unique protein interaction networks define the chromatin remodelling module of the NuRD complex., PMID:34231305
Computational study to evaluate the potency of phytochemicals in Boerhavia diffusa and the impact of point mutation on cyclin-dependent kinase 2-associated protein 1., PMID:33876720
Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex., PMID:33283408
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer., PMID:31897127
mRNA Expression of CDK2AP1 in Human Breast Cancer: Correlation with Clinical and Pathological Parameters., PMID:30343278
DYNC1H1 gene methylation correlates with severity of spinal muscular atrophy., PMID:30246859
Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation., PMID:29734353
miRNA-21 ablation protects against liver injury and necroptosis in cholestasis., PMID:29229992
DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells., PMID:28683324
The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities., PMID:27882936
p12CDK2-AP1 interacts with CD82 to regulate the proliferation and survival of human oral squamous cell carcinoma cells., PMID:27349208
Characterization of Two Distinct Nucleosome Remodeling and Deacetylase (NuRD) Complex Assemblies in Embryonic Stem Cells., PMID:26714524
miR-205 promotes proliferation and invasion of laryngeal squamous cell carcinoma by suppressing CDK2AP1 expression., PMID:26515287
Methylation levels of SLC23A2 and NCOR2 genes correlate with spinal muscular atrophy severity., PMID:25821969
Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence., PMID:25785833
CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro., PMID:25550687
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics., PMID:25123934
Clinical aggressiveness of myxofibrosarcomas associates with down-regulation of p12CDK2AP1: prognostic implication of a putative tumor suppressor that induces cell cycle arrest and apoptosis via mitochondrial pathway., PMID:24889487
Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma., PMID:24620959
Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle., PMID:24248101
Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer., PMID:23404055
Genome-wide analysis shows association of epigenetic changes in regulators of Rab and Rho GTPases with spinal muscular atrophy severity., PMID:23299920
Silencing P12CDK²AP¹ with a lentivirus promotes HaCaT cell proliferation., PMID:23229879
[Effect of CDK2-AP1 gene over-expression on proliferation and cell cycle regulation of breast cancer cell line MCF-7]., PMID:23117465
A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells., PMID:23074223
p12(CDK2-AP1) inhibits breast cancer cell proliferation and in vivo tumor growth., PMID:22828875
Expression of cyclin-dependent kinase 2-associated protein 1 confers an independent prognosticator in nasopharyngeal carcinoma: a cohort study., PMID:22791769
Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region., PMID:22427660
Double edge: CDK2AP1 in cell-cycle regulation and epigenetic regulation., PMID:21865592
Risk estimation for a malignant transformation of oral lesions by S100A7 and Doc-1 gene expression., PMID:21740085
miR-21 downregulates the tumor suppressor P12 CDK2AP1 and stimulates cell proliferation and invasion., PMID:21328460
Cell-cycle regulators cdk2ap1 and bicalutamide suppress malignant biological interactions between prostate cancer and bone cells., PMID:20812223
Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD., PMID:20733004
Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia., PMID:20727496
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci., PMID:20555355
Novel tumor growth inhibition mechanism by cell cycle regulator cdk2ap1 involves antiangiogenesis modulation., PMID:20541561
CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex., PMID:20523938
Progesterone is primary regulator of Cdk2ap1 gene expression and tissue-specific expression in the uterus., PMID:20354353
[Expression of cyclin-dependent kinase 2-associated protein 1 in chicken embryos of different sexes]., PMID:19819846
The DNA methylome of pediatric acute lymphoblastic leukemia., PMID:19679565
Cell cycle regulator cdk2ap1 inhibits prostate cancer cell growth and modifies androgen-responsive pathway function., PMID:19585490
Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation., PMID:19564334
For research use only. Not for human or drug use.
