Catalog No.
YHA20001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys19-Phe428
Predicted molecular weight
46.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14498
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ISLR, Immunoglobulin superfamily containing leucine-rich repeat protein
Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets., PMID:40304052
ALK1 Signaling in Human Cardiac Progenitor Cells Promotes a Pro-angiogenic Secretome., PMID:39430425
Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis., PMID:39136356
Screening of Secretory Proteins Linking Major Depressive Disorder with Heart Failure Based on Comprehensive Bioinformatics Analysis and Machine Learning., PMID:39062507
Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity., PMID:38786060
Toward harmonized interpretation of anticardiolipin and anti-β2-glycoprotein I antibody detection for diagnosis of antiphospholipid syndrome using defined level intervals and likelihood ratios: communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies., PMID:38704123
Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma., PMID:38600426
Islr regulates satellite cells asymmetric division through the SPARC/p-ERK1/2 signaling pathway., PMID:38597911
Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas., PMID:37796386
ISLR interacts with MGAT5 to promote the malignant progression of human gastric cancer AGS cells., PMID:37427332
Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice., PMID:37116777
Immune-based prognostic biomarkers associated with metastasis of osteosarcoma., PMID:36705300
Possible disease-protective roles of fibroblasts in cancer and fibrosis and their therapeutic application., PMID:36237894
Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis., PMID:36077405
A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases., PMID:35783639
Silencing of immunoglobulin superfamily containing leucine-rich repeat inhibits gastric cancer cell growth and metastasis by regulating epithelial-mesenchymal transition., PMID:35653801
CNN-LSTM Hybrid Real-Time IoT-Based Cognitive Approaches for ISLR with WebRTC: Auditory Impaired Assistive Technology., PMID:35237390
Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma., PMID:35209871
Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer., PMID:34713300
ISLR affects colon cancer progression by regulating the epithelial-mesenchymal transition signaling pathway., PMID:34520435
Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity., PMID:33960573
Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue., PMID:33760832
Bioinformatics analysis of autophagy-lysosomal degradation in cardiac aging., PMID:33233021
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis., PMID:33197448
SWATH-MS based proteomic profiling of pancreatic ductal adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways., PMID:33048956
Connective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma., PMID:32705221
ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway., PMID:32696215
A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study., PMID:32620509
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling., PMID:32128839
[Bioinformatics analysis of severe emphysema genome microarray based on GEO database]., PMID:31937048
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis., PMID:31439548
Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction., PMID:31221024
Gene expression profile in patients with Gaucher disease indicates activation of inflammatory processes., PMID:30988500
Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas., PMID:30982163
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy., PMID:30510196
A novel ISLR2-linked autosomal recessive syndrome of congenital hydrocephalus, arthrogryposis and abdominal distension., PMID:30483960
Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells., PMID:26924503
Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo., PMID:18848646
Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology., PMID:15489060
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling., PMID:11832495
Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression., PMID:10512678
Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)., PMID:9325048
For research use only. Not for human or drug use.
