Catalog No.
FHD96721
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
FITC
Target
Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, gammaC, p64, CD132, IL2RG
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
P31785
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
P1A10
Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851
Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies., PMID:40132909
2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus., PMID:39551768
Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics., PMID:36498937
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program., PMID:36171288
T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation., PMID:35527320
Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency., PMID:35157765
Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome., PMID:34248995
A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells., PMID:34011961
Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species., PMID:33328333
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells., PMID:33293281
A Method of Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood., PMID:32508837
Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation., PMID:31406267
Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1., PMID:30995372
Dissemination of Orientia tsutsugamushi, a Causative Agent of Scrub Typhus, and Immunological Responses in the Humanized DRAGA Mouse., PMID:29760694
CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells., PMID:29514797
IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody., PMID:27306531
A New IL-2RG Gene Mutation in an X-linked SCID Identified through TREC/KREC Screening: a Case Report., PMID:26547715
Cytomegalovirus Encephalitis in a Patient with Severe Combined Immunodeficiency., PMID:26546317
Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis., PMID:26260924
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum., PMID:26183780
In vivo maintenance of human regulatory T cells during CD25 blockade., PMID:25416807
Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD., PMID:25352130
Successful treatment for West syndrome with severe combined immunodeficiency., PMID:24534054
Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera., PMID:24512738
Infectious bursal disease virus influences the transcription of chicken γc and γc family cytokines during infection., PMID:24416239
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage., PMID:23963040
Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development., PMID:23722894
Clinical characteristics and genetic profiles of 44 patients with severe combined immunodeficiency (SCID): report from Shanghai, China (2004-2011)., PMID:23250629
Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia., PMID:23212516
Application of IL-2 therapy to target T regulatory cell function., PMID:22951308
Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor., PMID:22737248
Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion., PMID:22382400
Signalling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria., PMID:21585397
Efficacy of gene therapy for X-linked severe combined immunodeficiency., PMID:20660403
Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain., PMID:19819255
Disengaging the IL-2 receptor with daclizumab enhances IL-7-mediated proliferation of CD4(+) and CD8(+) T cells., PMID:19788505
Development of a quantitative bead capture assay for soluble IL-7 receptor alpha in human plasma., PMID:19690616
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin., PMID:19543393
Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma., PMID:19155487
Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain., PMID:18829468
Clinical and immunologic consequences of a somatic reversion in a patient with X-linked severe combined immunodeficiency., PMID:18728247
Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera., PMID:18589435
Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4+ T cell proliferation by murine macrophages., PMID:18190607
Interleukin-21 signaling: functions in cancer and autoimmunity., PMID:18056166
Pharmacological immunomodulation of surgical trauma., PMID:17972216
Expression and structure of interleukin 4 receptor (IL-4R) complex in human invasive pituitary adenomas., PMID:17398005
CD25-expressing B-lymphocytes in rheumatic diseases., PMID:17257224
B-cell CD25 expression in murine primary and secondary lymphoid tissue., PMID:17032240
Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein., PMID:16967044
For research use only. Not for human or drug use.
