Catalog No.
YHA18401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr67-His185
Predicted molecular weight
15.49 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00746
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NDP kinase, mitochondrial, NDK, nm23-H4, Nucleoside diphosphate kinase, mitochondrial, Nucleoside diphosphate kinase D, NM23D, NME4, NDPKD
Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores., PMID:40340313
Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma., PMID:39455097
NME4 suppresses NFκB2-CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma., PMID:39016535
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases., PMID:38180572
Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes., PMID:38077434
Mechanisms of action of NME metastasis suppressors - a family affair., PMID:37353690
Molecular and Pathological Analyses of IARS1-Deficient Mice: An IARS Disorder Model., PMID:37108118
Differential Expression of NME4 in Trophoblast Stem-Like Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy and Preeclampsia., PMID:37096311
Cluster of resistance-inducing genes in MCF-7 cells by estrogen, insulin, methotrexate and tamoxifen extracted via NMF., PMID:36738509
Integrative analysis of the proteome and transcriptome in gastric cancer identified LRP1B as a potential biomarker., PMID:36606427
Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition., PMID:35853430
Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines., PMID:35681623
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs., PMID:35414338
NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix., PMID:34789336
The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor., PMID:34674701
A Novel Integrated Metabolism-Immunity Gene Expression Model Predicts the Prognosis of Lung Adenocarcinoma Patients., PMID:34393804
The let-7f-5p-Nme4 pathway mediates tumor necrosis factor α-induced impairment in osteogenesis of bone marrow-derived mesenchymal stem cells., PMID:34297624
Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: Implication of reducing cancer recurrence risk., PMID:34194828
Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks., PMID:33959661
Emerging Molecular Connections between NM23 Proteins, Telomeres and Telomere-Associated Factors: Implications in Cancer Metastasis and Ageing., PMID:33801585
Nanomechanics of π-cation-π interaction with implications for bio-inspired wet adhesion., PMID:33007483
NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability., PMID:32708927
Widely targeted metabolomic analyses unveil the metabolic variations after stable knock-down of NME4 in esophageal squamous cell carcinoma cells., PMID:32504364
NME4 modulates PD-L1 expression via the STAT3 signaling pathway in squamous cell carcinoma., PMID:32192776
Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity., PMID:32004439
Characterization of Nme5-Like Gene/Protein from the Red Alga Chondrus Crispus., PMID:31877804
NME4 may enhance non‑small cell lung cancer progression by overcoming cell cycle arrest and promoting cellular proliferation., PMID:31257488
The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis., PMID:29491425
NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy., PMID:29035377
NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy., PMID:26742431
Cation-π interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation., PMID:26467787
OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway., PMID:25233933
Structural comparison of highly similar nucleoside-diphosphate kinases: Molecular explanation of distinct membrane-binding behavior., PMID:25010650
Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling., PMID:24970086
High-resolution analysis of cis-acting regulatory networks at the α-globin locus., PMID:23650635
Analysis of sequence variation underlying tissue-specific transcription factor binding and gene expression., PMID:23616472
Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch., PMID:23150663
Role of carboxylate side chains in the cation Hofmeister series., PMID:22697172
Denaturation of proteins by SDS and tetraalkylammonium dodecyl sulfates., PMID:21834533
ATRX: taming tandem repeats., PMID:21099363
Effects of combined siRNA-TR and -TERT on telomerase activity and growth of bladder transitional cell cancer BIU-87 cells., PMID:20556588
Adventitious changes in long-range gene expression caused by polymorphic structural variation and promoter competition., PMID:19959666
Nme protein family evolutionary history, a vertebrate perspective., PMID:19852809
Interaction of NDPK-D with cardiolipin-containing membranes: Structural basis and implications for mitochondrial physiology., PMID:19254751
The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration., PMID:18635542
High expression of ERCC1, FLT1, NME4 and PCNA associated with poor prognosis and advanced stages in myelodysplastic syndrome., PMID:18604718
Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry., PMID:18575723
Cation [M = H+, Li+, Na+, K+, Ca2+, Mg2+, NH4+, and NMe4+] interactions with the aromatic motifs of naturally occurring amino acids: a theoretical study., PMID:16834293
Expression patterns of nm23 genes during mouse organogenesis., PMID:16082520
Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer., PMID:15726650
For research use only. Not for human or drug use.
