Catalog No.
YHA09001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr232
Predicted molecular weight
28.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00311
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HsCdc7, CDC7L1, Cell division cycle 7-related protein kinase, CDC7-related kinase, huCdc7, CDC7
Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration., PMID:40340943
Immunohistochemistry and machine learning study of DNA replication-associated proteins in uterine epithelial tumors and precursor lesions., PMID:40220589
Gene expression analysis in circulating tumour cells to determine resistance to CDK4/6 inhibitors plus endocrine therapy in HR + /HER2- metastatic breast cancer patients., PMID:40186268
Pan-cancer analysis of CDC7 in human tumors: Integrative multi-omics insights and discovery of novel marine-based inhibitors through machine learning and computational approaches., PMID:40120182
Recent advances in CDC7 kinase inhibitors: Novel strategies for the treatment of cancers and neurodegenerative diseases., PMID:40090297
Development of a prognostic model based on the ceRNA network in Triple-Negative Breast cancer., PMID:40034665
Experimental, Theoretical, and In Silico Studies of Potential CDC7 Kinase Inhibitors., PMID:39829445
Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma., PMID:39815239
Proteome-wide forced interactions reveal a functional map of cell-cycle phospho-regulation in S. cerevisiae., PMID:39618027
The Genomic Landscape of Wilson Disease in a Pan India Disease Cohort and Population-Scale Data., PMID:39535360
CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer., PMID:39412086
Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks., PMID:39194567
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation., PMID:39054323
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks., PMID:38865090
RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair., PMID:38719812
CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation., PMID:38677657
CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells., PMID:38555567
Nanosystem Delivers Senescence Activators and Immunomodulators to Combat Liver Cancer., PMID:38520730
Potts Hamiltonian Models and Molecular Dynamics Free Energy Simulations for Predicting the Impact of Mutations on Protein Kinase Stability., PMID:38350894
The ORFIUS complex regulates ORC2 localization at replication origins., PMID:38288445
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy., PMID:38278156
Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase., PMID:38205514
Evaluation of cell proliferation marker CDC-7 in salivary adenoid cystic carcinoma., PMID:38183819
Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer., PMID:37992591
CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade., PMID:37980406
Protein kinase Cdc7 supports viral replication by phosphorylating Avibirnavirus VP3 protein., PMID:37902398
Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7., PMID:37866880
Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins., PMID:37811746
CDC7 kinase inhibitors: a survey of recent patent literature (2017-2022)., PMID:37735909
Cdc7 kinase is required for postnatal brain development., PMID:37584256
Rif1 restrains the rate of replication origin firing in Xenopus laevis., PMID:37516798
DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy., PMID:37497004
Multiple suppressing small interfering RNA for cancer treatment-Application to triple-negative breast cancer., PMID:37478121
Azaindole derivatives as potential kinase inhibitors and their SARs elucidation., PMID:37423125
PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors., PMID:37378325
ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion., PMID:37336885
Safety, Tolerability, and Pharmacokinetics of TAK-931, a Cell Division Cycle 7 Inhibitor, in Patients with Advanced Solid Tumors: A Phase I First-in-Human Study., PMID:36970056
Homozygous DBF4 mutation as a cause of severe congenital neutropenia., PMID:36841265
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening., PMID:36725843
Claspin is Required for Growth Recovery from Serum Starvation through Regulating the PI3K-PDK1-mTOR Pathway in Mammalian Cells., PMID:36720467
Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma., PMID:36609254
CDC7 Expression in Selected Odontogenic Tumors., PMID:36483932
Degree of stemness predicts micro-environmental response and clinical outcomes of diffuse large B-cell lymphoma and identifies a potential targeted therapy., PMID:36426371
WEE1 inhibition augments CDC7 (DDK) inhibitor-induced cell death in Ewing sarcoma by forcing premature mitotic entry and mitotic catastrophe., PMID:36338546
Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis., PMID:35926565
The interaction between the Dbf4 ortholog Chiffon and Gcn5 is conserved in Dipteran insect species., PMID:35789507
A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission., PMID:35754741
Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study., PMID:35708873
CDC7 as a novel biomarker and druggable target in cancer., PMID:35657477
The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer., PMID:35614055
For research use only. Not for human or drug use.
