Catalog No.
YHA08501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys79-Lys241
Predicted molecular weight
20.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00299
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Regulatory nuclear chloride ion channel protein, CLIC1, NCC27, Nuclear chloride ion channel 27, Chloride channel ABP, Chloride intracellular channel protein 1, hRNCC, G6
Tissue Prognostic Markers for Clear Cell Renal Cell Carcinoma Tumor-stroma Interaction: Impact on TNM Staging Parameters., PMID:40425350
Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities., PMID:40235733
CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease., PMID:40215772
Prediction of potential targets of aloe-emodin in the treatment of hepatocellular carcinoma using network pharmacology combined with bioinformatics., PMID:40186059
Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development., PMID:39994764
Chloride Intracellular Channel 1 Enhances Glioblastoma Cell Migration and Epithelial-Mesenchymal Transition by Activating the ERK1/2 Signaling Pathway., PMID:39976102
Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis., PMID:39953602
Chloride intracellular channel (CLIC) protein function in S1P-induced Rac1 activation requires membrane localization of the C-terminus, but not thiol-transferase nor ion channel activities., PMID:39896666
Sex-specific transcriptomic profiling reveals key players in bone loss associated with Alzheimer's disease., PMID:39875754
Proteomics and Recurrence of Atrial Fibrillation: A Pilot Study Nested in the PREDIMAR Trial., PMID:39864423
Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing., PMID:39432400
Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons., PMID:39356770
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer., PMID:39154343
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers., PMID:38835753
Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics., PMID:38735925
Retrograde AAV-mediated gene modulation reveals chloride intracellular channel proteins as potent regulators of retinal ganglion cell death., PMID:38714284
Salivary Chloride Intracellular Channel 1 (CLIC1) as a Hub of Gene-Gene Interactome of Periodontitis With Diabetes Mellitus., PMID:38327933
TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation., PMID:38290591
Integrating Machine Learning and Mendelian Randomization Determined a Functional Neurotrophin-Related Gene Signature in Patients with Lower-Grade Glioma., PMID:38261152
Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication., PMID:38257829
Integrating bulk and single-cell RNA sequencing data reveals epithelial-mesenchymal transition molecular subtype and signature to predict prognosis, immunotherapy efficacy, and drug candidates in low-grade gliomas., PMID:38053842
CLIC1 regulation of cancer stem cells in glioblastoma., PMID:38007271
A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation., PMID:37942902
Inhibition of chloride intracellular channel protein 1 (CLIC1) ameliorates liver fibrosis phenotype by activating the Ca2+-dependent Nrf2 pathway., PMID:37924785
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer., PMID:37799381
In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins., PMID:37759794
Membrane procoagulation and N‑terminomics/TAILS profiling in Montreal platelet syndrome kindred with VWF p.V1316M mutation., PMID:37735203
Intracellular chloride channel 1 and tumor., PMID:37693147
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight., PMID:37604246
Chloride intracellular channel protein-1 (CLIC1) antibody in multiple sclerosis patients with predominant optic nerve and spinal cord involvement., PMID:37603930
Extracellular Acidification Augments NLRP3-Mediated Inflammasome Signaling in Macrophages., PMID:37416933
CLIC4 Regulates Endothelial Barrier Control by Mediating PAR1 Signaling via RhoA., PMID:37317855
CLIC1-mediated autophagy confers resistance to DDP in gastric cancer., PMID:37104099
Chloride Intracellular Channel Protein 1 Expression and Angiogenic Profile of Liver Metastasis of Digestive Origin., PMID:36826036
Sterol Structural Features' Impact on the Spontaneous Membrane Insertion of CLIC1 into Artificial Lipid Membranes., PMID:36821411
Label-free LC-MS/MS proteomics analyses reveal CLIC1 as a predictive biomarker for bladder cancer staging and prognosis., PMID:36727059
Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute Pancreatitis., PMID:36671463
The Mutually Mediated Chloride Intracellular Channel Protein 1 (CLIC1) Relationship between Malignant Cells and Tumor Blood Vessel Endothelium Exhibits a Significant Impact on Tumor Angiogenesis, Progression, and Metastasis in Clear Cell Renal Cell Carcinoma (ccRCC)., PMID:36497464
A metazoan-specific C-terminal motif in EXC-4 and Gα-Rho/Rac signaling regulate cell outgrowth during tubulogenesis in C. elegans., PMID:36398726
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension., PMID:36264759
Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling., PMID:36252281
CLIC1 plasma concentration is associated with lymph node metastases in oral squamous cell carcinoma., PMID:36251793
Chloride Intracellular Channel Proteins (CLICs) and Malignant Tumor Progression: A Focus on the Preventive Role of CLIC2 in Invasion and Metastasis., PMID:36230813
Comprehensive analysis of clinical prognosis and CLIC1 immune invasion in lung adenocarcinoma., PMID:36181109
Nuclear localisation sequences of chloride intracellular channels 1 and 4 facilitate nuclear import via interactions with import mediator importin-α: An empirical and theoretical perspective., PMID:36175369
Deep multilayer brain omics identifies the potential involvement of menopause molecular networks in Gliomas' disease progression., PMID:36165217
Human antimicrobial peptide LL-37 contributes to Alzheimer's disease progression., PMID:36138130
SLC26A4 Mutation Promotes Cell Apoptosis by Inducing Pendrin Transfer, Reducing Cl- Transport, and Inhibiting PI3K/Akt/mTOR Pathway., PMID:36072472
Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer., PMID:36045598
Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1., PMID:35905561
For research use only. Not for human or drug use.
