Catalog No.
YHA07201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser224-Pro395
Predicted molecular weight
22.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00255
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MEN1, Menin, SCG2
Familial Mahvash disease with metastatic pancreatic NET and MEN1 mutations., PMID:40424057
Case Report: A novel likely pathogenetic variant of the MEN1 gene in multiple endocrine neoplasia type 1., PMID:40421248
Safety and Efficacy of Peptide Receptor Radionuclide Therapy in Multiple Endocrine Neoplasia Syndrome: A Single-center Experience., PMID:40392141
An Updated Perspective of the Clinical Features and Parathyroidectomy Impact in Primary Hyperparathyroidism Amid Multiple Endocrine Neoplasia Type 1 (MEN1): Focus on Bone Health., PMID:40364143
Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights., PMID:40362680
Case Report: Late diagnosis of McCune-Albright with severe kyphoscoliosis, acromegaly and tertiary hyperparathyroidism., PMID:40357201
Oncocytic subtype of well differentiated neuroendocrine tumor: clinicopathologic and molecular associations of a cohort diagnosed on fine needle aspiration (FNA)., PMID:40345926
Non-recurrent mutations and copy number changes predominate pituitary adenoma genomes., PMID:40300997
Heterozygous Men1(+/T) Knockout Mice Do Not Develop Bronchopulmonary Neuroendocrine Hyperplasia or Neoplasia but Bronchial Adenocarcinoma., PMID:40277511
A Novel Mutation in a Family With Multiple Endocrine Neoplasia Type 1 and Aggressive Pancreatic Neuroendocrine Tumors., PMID:40201469
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups., PMID:40185092
Decoding the genetic puzzle: Mutations in key driver genes of pancreatic neuroendocrine tumors., PMID:40158667
Menin: from molecular insights to clinical impact., PMID:40152985
Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition., PMID:40102405
EWSR1::CREM Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor., PMID:40072299
Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer., PMID:40057469
Molecular basis of symptomatic sporadic primary hyperparathyroidism: New frontiers in pathogenesis., PMID:40057423
Differentiation Versus Grade for Pancreatic Neuroendocrine Neoplasms., PMID:40031961
Mirrored Metastatic Neuroendocrine Tumor in a Mother-Daughter Duo With Mutations in the MEN1 Gene., PMID:40016943
Menin inhibitor MI-503 exhibits potent anti-cancer activity in osteosarcoma., PMID:40016386
A novel likely pathogenic germline variant in CDKN1B in a patient with MEN4 and medullary thyroid cancer., PMID:40009226
Should we worry about high-grade pancreatic neuroendocrine tumor progression and alkylating agents?†., PMID:40007046
Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome., PMID:39985924
Hsp70 incompletely disaggregates misfolded K488X-menin to promote tumourigenesis in a family with multiple endocrine neoplasia type 1., PMID:39978610
Genotype-phenotype correlation in multiple endocrine neoplasia type 1., PMID:39946193
Pharmacokinetics and ADME Characterization After Oral and Intravenous Administration of [14C]-Ziftomenib in Healthy Male Participants., PMID:39928533
Targeted inhibition of menin promotes β-catenin-mediated GLP-1 expression and improves glucose tolerance in high-fat diet-induced obese mice., PMID:39907684
A comprehensive high-throughput screening approach for discovering inhibitors targeting the menin-MLL1 interaction., PMID:39843145
Progress report on multiple endocrine neoplasia type 1., PMID:39826015
Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis., PMID:39817905
Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumours., PMID:39804242
Menin Inhibitors: New Targeted Therapies for Specific Genetic Subtypes of Difficult-to-Treat Acute Leukemias., PMID:39796769
Genotype-Phenotype Correlations in the Hyperparathyroidism-Jaw Tumor Syndrome., PMID:39775826
[Review of Multiple Endocrine Neoplasia Type 1 Based on a Clinical Case]., PMID:39760567
Tatton-Brown-Rahman syndrome: A new multiple endocrine neoplasia syndrome with intellectual disability?, PMID:39734048
Menin inhibitors in the treatment of acute myeloid leukemia., PMID:39719041
Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia., PMID:39704147
Alternative splicing generates isoform diversity in MEN1., PMID:39649118
Genotype-based prognosis prediction for MEN1-Related pancreatic neuroendocrine tumors in Korean patients a single-center retrospective study., PMID:39638700
Sarcomas arising in MEN1 patients: demonstrating LOH of the MEN1 locus and loss of menin expression., PMID:39609309
Targeting Menin in Acute Myeloid Leukemia: Therapeutic Advances and Future Directions., PMID:39594699
Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma., PMID:39579612
Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms., PMID:39579056
Improving early diagnosis of multiple endocrine neoplasia type 1 by assessing the gastrointestinal symptoms, hypercalcemia, and elevated serum gastrin., PMID:39575405
Menin inhibitors for the treatment of acute myeloid leukemia: challenges and opportunities ahead., PMID:39558390
Progression of Low-Grade Neuroendocrine Tumors (NET) to High-Grade Neoplasms Harboring the NEC-Like Co-alteration of RB1 and TP53., PMID:39556303
Genetic Landscape and Clinical Manifestations of Multiple Endocrine Neoplasia Type 1 in a Korean Cohort: A Multicenter Retrospective Analysis., PMID:39552147
Molecular Pathophysiology of Parathyroid Tumorigenesis-The Lesson from a Rare Disease: The "MEN1 Model"., PMID:39519139
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML., PMID:39475509
MLL oncoprotein levels influence leukemia lineage identities., PMID:39472576
For research use only. Not for human or drug use.
