Catalog No.
YHA03301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln765-Asn1011
Predicted molecular weight
54.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00159
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Myosin I beta, MMI-beta, MMIb, MYO1C, Unconventional myosin-Ic
The Allosteric Inhibitor Pentachloropseudilin Inhibits Myosin 1C ATPase Activity and Recapitulates Retinitis Pigmentosa Phenotypes in Mice., PMID:40454028
High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory., PMID:40014570
Investigating gene expression datasets of hippocampus tissue to discover Alzheimer's disease-associated molecular markers., PMID:39604273
Myo1c drives actin-dependent VWF expulsion from EC WPBs., PMID:39254967
Liraglutide Promotes Diabetic Wound Healing via Myo1c/Dock5., PMID:39159301
A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling., PMID:39112516
Myosin-1C differentially displaces tropomyosin isoforms altering their inhibition of motility., PMID:38971309
Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease., PMID:38904753
Minimal Change Disease: Pathogenetic Insights from Glomerular Proteomics., PMID:38891801
The Logistical Backbone of Photoreceptor Cell Function: Complementary Mechanisms of Dietary Vitamin A Receptors and Rhodopsin Transporters., PMID:38673863
Myosin-1C augments endothelial secretion of von Willebrand factor by linking contractile actomyosin machinery to the plasma membrane., PMID:38669344
Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease., PMID:38659911
Pathophysiology of human hearing loss associated with variants in myosins., PMID:38562617
Left-right Myosin-Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages., PMID:38454557
RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C., PMID:37953466
iTRAQ-based proteomics reveals potential markers and treatment pathways for acute Achilles tendon rupture., PMID:37946221
Identification of urinary extracellular vesicles differentially expressed RNAs in diabetic nephropathy via whole-transcriptome integrated analysis., PMID:37738894
In Silico Prediction of MYO1C-Rhodopsin Interactions and Its Significance in Protein Localization and Visual Function., PMID:37440078
Cell fragmentation in mouse preimplantation embryos induced by ectopic activation of the polar body extrusion pathway., PMID:37427462
Drosophila class-I myosins that can impact left-right asymmetry have distinct ATPase kinetics., PMID:37380077
hucMSCs treatment prevents pulmonary fibrosis by reducing circANKRD42-YAP1-mediated mechanical stiffness., PMID:37335082
m6A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1 manner., PMID:36781839
Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19., PMID:36736950
SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C., PMID:36513634
Collagen IV and Podocyte-Related Gene Variants in Patients with Concurrent IgA Nephropathy and Thin Basement Membrane Nephropathy., PMID:36349777
Necroptosis-Related Prognostic Signature and Nomogram Model for Predicting the Overall Survival of Patients with Lung Cancer., PMID:36101745
Quantitative proteomic analysis of gingival crevicular fluids to identify novel biomarkers of gingival recession in orthodontic patients., PMID:35779762
The role of motor proteins in photoreceptor protein transport and visual function., PMID:35470760
A Class of Protein-Coding RNAs Binds to Polycomb Repressive Complex 2 and Alters Histone Methylation., PMID:34804929
iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning., PMID:34705028
SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line., PMID:34380438
Loss of Motor Protein MYO1C Causes Rhodopsin Mislocalization and Results in Impaired Visual Function., PMID:34073294
Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer., PMID:34019593
Myosin 1c: A novel regulator of glucose uptake in brown adipocytes., PMID:33965643
The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus., PMID:33918018
Targeting myosin 1c inhibits murine hepatic fibrogenesis., PMID:33908271
Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization., PMID:33676037
Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes., PMID:33399853
Mechanochemical properties of human myosin-1C are modulated by isoform-specific differences in the N-terminal extension., PMID:33257319
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value., PMID:33201534
Dictyostelium myosin 1F and myosin 1E inhibit actin waves in a lipid-binding-dependent and motor-independent manner., PMID:32734648
Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells., PMID:32589349
Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes., PMID:32211535
Putting the brakes on a myosin motor., PMID:32198186
Identification of the differential expression of genes and upstream microRNAs in small cell lung cancer compared with normal lung based on bioinformatics analysis., PMID:32176034
Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism., PMID:32161327
Glioma-derived endothelial cells promote glioma cells migration via extracellular vesicles-mediated transfer of MYO1C., PMID:32081419
The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation., PMID:31811090
Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s., PMID:31774725
Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network., PMID:31699152
For research use only. Not for human or drug use.
