Catalog No.
YHA02601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu431
Predicted molecular weight
51.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00141
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SGK, Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1, SGK1
SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway. PMID: 29017179
The functional duality of SGK1 in the regulation of hyperglycemia. PMID: 32621586
Exploring serum and glucocorticoid-regulated kinase 1: A promising target for COVID-19 and atrial fibrillation treatment., PMID:40496592
Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K/SGK1/Foxo3 signaling pathway., PMID:40457271
Unraveling the Potential of SGK1 in Osteoporosis: From Molecular Mechanisms to Therapeutic Targets., PMID:40427579
SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells., PMID:40402207
Salvia miltiorrhiza-derived exosome-like nanoparticles improve diabetic cardiomyopathy by inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis via targeting the NEDD4/SGK1 axis., PMID:40391625
High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation., PMID:40383790
Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, inhibits adrenal aldosterone synthesis and renal ERK/EGR1 pathway in the treatment of diabetic kidney disease., PMID:40348304
Inhibition of Fin Regeneration in Fathead Minnow (Pimephales promelas) by a Potent Synthetic Glucocorticoid and Development of Adverse Outcome Pathway 334., PMID:40326831
Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation., PMID:40316059
[4‑(Arylethyl)‑pyrrolo[2,3-d] pyrimidine improves post-traumatic stress disorder in mice by inhibiting mGluR5-regulated ERK1/2-SGK1 signaling pathway]., PMID:40294927
Regulation of glucocorticoid receptor nuclear localization in prostate cancer cells., PMID:40288208
Esaxerenone Improves Vascular Endothelial Dysfunction by Reducing Serum and Glucocorticoid-Regulated Kinase 1 Activity and Enhancing the Akt Pathway in Type 2 Diabetic Mice., PMID:40268465
Anxa10 and neuropathic pain: Insights into dysregulation of endoplasmic reticulum-mitochondria contact tethering complex and therapeutic potential., PMID:40250776
Effect of chronic corticosterone administration on acute stress-mediated gene expression in the cortex and hippocampus of male mice., PMID:40199127
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure., PMID:40195316
SGK1 upregulation in GFAP+ neurons in the frontal association cortex protects against neuronal apoptosis after spinal cord injury., PMID:40175324
Hypoxia-induced NDRG1 C-terminal poly-phosphorylation impairs its tumor suppressor function in renal cell carcinoma., PMID:40139342
Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12., PMID:40100301
Elucidation of Dexmedetomidine-Induced Analgesic Tolerance Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and NR2B Expression via the Spinal SGK1/NF-κB Signalling Pathway., PMID:40099662
MALAT1 promotes microglia activation and neuronal apoptosis through via the miR-124-3p/ SGK1 axis mediating experimental autoimmune encephalomyelitis disease progression in mice., PMID:40090080
Berbamine alleviates neuropathic pain via suppressing spinal TMEM34/SGK1/FOXO3 axis., PMID:40088745
Integrative Phosphoproteomic and Metabolomic Analysis of Disruption of Metabolic Homeostasis in Breast Cancer: A Pilot Study., PMID:40063314
Isoliquiritigenin Ameliorates High-Fat Diet-Induced Obesity in Mice by Activating Brown Adipose Tissue., PMID:40004080
Pseudomonas aeruginosa-derived DnaJ induces TLR2 expression through TLR10-mediated activation of the PI3K-SGK1 pathway in macrophages., PMID:39978578
SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice., PMID:39962079
SGK1-HDAC4-HMGB1 signaling pathway in the spinal cord dorsal horn participates in diabetic neuropathic pain., PMID:39921539
Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity., PMID:39908792
A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance., PMID:39896456
Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking., PMID:39884015
Intestinal RICT-1 regulates the larval germline progenitor pool via the vitellogenin VIT-3 in C. elegans., PMID:39829881
Nelumbo nucifera Petals Ameliorate Depressive-like Symptom and Cognitive Deficit in Unpredictable Chronic Mild Stress Mouse Model., PMID:39796528
Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer's Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis., PMID:39745486
The role of SGK1 in neurologic diseases: A friend or foe?, PMID:39737082
SGK1 mediates herpes simplex keratitis via the PI3K/SGK1/ Wnt signaling pathways., PMID:39674392
SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Thoracic Aortic Dissection Progression., PMID:39633576
FoxO1 signaling in B cell malignancies and its therapeutic targeting., PMID:39533662
Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies., PMID:39518961
Insufficient S-sulfhydration of serum and glucocorticoid-regulated kinase 1 participates in hyperhomocysteinemia-induced liver injury., PMID:39427745
Gene expression profiling in Venous thromboembolism: Insights from publicly available datasets., PMID:39413445
A novel gain-of-function mutation in sgk-1 partially suppresses mTORC2 defects., PMID:39410967
Cholesterol promotes IFNG mRNA expression in CD4+ effector/memory cells by SGK1 activation., PMID:39366761
Transcriptomic Profiles of AKAP12 Deficiency in Mouse Corpus Callosum., PMID:39345723
Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain., PMID:39326820
SGK1 suppresses ferroptosis in ovarian cancer via NRF2-dependent and -independent pathways., PMID:39306614
Exosomal transcript cargo and functional correlation with HNSCC patients' survival., PMID:39272022
SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway., PMID:39245317
Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases., PMID:39209082
CFTR Inhibitors Display Antiviral Activity against Herpes Simplex Virus., PMID:39205282
An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction., PMID:39196959
Efficacy of Saccharomyces yeast postbiotics on cell turnover, immune responses, and oxidative stress in the jejunal mucosa of young pigs., PMID:39164530
For research use only. Not for human or drug use.
