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Recombinant Human RBFOX3 Protein, N-His

Catalog #:   YHA00601 Specific References (91) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: A6NFN3
Protein length: Met1-Arg100
Overview

Catalog No.

YHA00601

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Met1-Arg100

Predicted molecular weight

13.07 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

A6NFN3

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Neuronal nuclei antigen, RBFOX3, RNA binding protein fox-1 homolog 3, NeuN antigen, Fox-1 homolog C

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human RBFOX3 protein
References

RBFOX3/NeuN is dispensable for visual function. PMID: 29401485

RBFOX3 Promotes Gastric Cancer Growth and Progression by Activating HTERT Signaling. PMID: 32903312

Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10. PMID: 30475774

RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways. PMID: 29689552

RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function. PMID: 26619789

Rbfox3 controls the biogenesis of a subset of microRNAs. PMID: 25240799

RBFOX3 regulates Claudin-1 expression in human lung tissue via attenuation of proteasomal degradation. PMID: 28126724

RBFOX3 Promotes Tumor Growth and Progression via hTERT Signaling and Predicts a Poor Prognosis in Hepatocellular Carcinoma. PMID: 28839469

Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. PMID: 23420872

Genetic variants in RBFOX3 are associated with sleep latency. PMID: 27142678

Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-kappaB/COX-2 signaling pathways. PMID: 30550850

Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PMID: 27701470

Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo. PMID: 26952657

Retraction: RBFOX3 Promotes Gastric Cancer Growth and Progression by Activating HTERT Signaling. PMID: 34532292

NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PMID: 21747913

Transforming Growth Factor-beta-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells. PMID: 27432190

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. PMID: 31204559

Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects. PMID: 25760045

Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development. PMID: 25044120

PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. PMID: 31238788

RBFOX1 and RBFOX3 mutations in rolandic epilepsy. PMID: 24039908

Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. PMID: 31234698

Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. PMID: 30304977

Autophagy modulates SNCA/伪-synuclein release, thereby generating a hostile microenvironment. PMID: 25484190

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PMID: 30281647

Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. PMID: 31469345

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. PMID: 25484084

Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). PMID: 24215932

The molecular basis of the specificity and cross-reactivity of the NeuN epitope of the neuron-specific splicing regulator, Rbfox3. PMID: 24150744

Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN. PMID: 30124848

PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. PMID: 33317392

Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants. PMID: 34039076

A pilot study on searching for peri-nuclear NeuN-positive cells. PMID: 31938576

Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration. PMID: 32204565

Rbfox family proteins make the homo- and hetero-oligomeric complexes. PMID: 29170129

Genetic variants in splicing factor genes and susceptibility to bladder cancer. PMID: 34673209

Novel Insights into NeuN: from Neuronal Marker to Splicing Regulator. PMID: 25680637

Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome. PMID: 32033960

Subcutaneous priming of protein-functionalized chitosan scaffolds improves function following spinal cord injury. PMID: 32204084

Relative Resilience of Cerebellar Purkinje Cells in a Cardiac Arrest/Resuscitation Rat Model. PMID: 31396839

Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke. PMID: 32728189

Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice., PMID:40251497

Characterization of the Rbfox3-IRES-iCre knock-in mouse: Revealing gene recombination activity in neural and non-neural peripheral tissues., PMID:40212807

Unraveling the crucial role of UPR pathway in rat brain development., PMID:40208490

Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicing., PMID:40166205

Rare disease gene association discovery in the 100,000 Genomes Project., PMID:40011789

Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux., PMID:39936620

Rbfox3 Promotes Transformation of MDSC-Like Tumor Cells to Shape Immunosuppressive Microenvironment., PMID:39777898

Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies., PMID:39774335

Oxidative stress and apoptosis of the spinal cord in a rat model of retinoic acid-induced neural tube defects., PMID:39633511

Kaixinsan regulates neuronal mitochondrial homeostasis to improve the cognitive function of Alzheimer's disease by activating CaMKKβ-AMPK-PGC-1α signaling axis., PMID:39520951

The long-term effects of limbic non-convulsive status epilepticus in peri-adolescent rats., PMID:39476704

Neuronal splicing regulator RBFOX3 (NeuN) distribution and organization are modified in response to monosodium glutamate in rat brain at postnatal day 14., PMID:39427608

Regeneration and Plasticity Induced by Epidural Stimulation in a Rodent Model of Spinal Cord Injury., PMID:39201729

Estrogens dynamically regulate neurogenesis in the dentate gyrus of adult female rats., PMID:39166359

Large-scale proteomics reveals precise biomarkers for detection of ovarian cancer in symptomatic women., PMID:39068297

Elucidating the molecular mechanisms behind the therapeutic impact of median nerve stimulation on cognitive dysfunction post-traumatic brain injury., PMID:38901771

Gene-gene interaction analysis for age at onset of bipolar disorder in a Korean population., PMID:38834091

Ursolic acid molecules dock MAPK1 to modulate gut microbiota diversity to reduce neuropathic pain., PMID:38570065

Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain., PMID:38522078

Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice., PMID:38373108

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies., PMID:38334634

Paclitaxel-induced inhibition of NSCLC invasion and migration via RBFOX3-mediated circIGF1R biogenesis., PMID:38191906

Hypothermic Protection in Neocortex Is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein Rbfox3/NeuN in Neonatal Hypoxic-Ischemic Male Piglets., PMID:37887298

PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes., PMID:37832540

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia., PMID:37712850

Genome-wide exploration of genetic interactions for bladder cancer risk., PMID:37638657

Isoflavones Mediate Dendritogenesis Mainly through Estrogen Receptor α., PMID:37240356

Spatial Gene Expression Analysis Reveals Characteristic Gene Expression Patterns of De Novo Neuroendocrine Prostate Cancer Coexisting with Androgen Receptor Pathway Prostate Cancer., PMID:37240308

Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment., PMID:37204119

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles., PMID:37127706

Mice deficient for G-protein-coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall., PMID:36978267

FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation., PMID:36170234

Cannabidiol Promotes Neuronal Differentiation Using Akt and Erk Pathways Triggered by Cb1 Signaling., PMID:36080415

Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons., PMID:35951651

Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion., PMID:35606902

Global Exploration of RNA-Binding Proteins in Exercise-Induced Adult Hippocampal Neurogenesis: A Transcriptome Meta-analysis and Computational Study., PMID:35546218

NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer's Disease., PMID:35406633

The effect of prolonged formalin fixation on the expression of proteins in human brain tissues., PMID:35358895

MUC1 deficiency induces the nasal epithelial barrier dysfunction via RBFOX3 shortage augment ubiquitin-proteasomal degradation in allergic rhinitis pathogenesis., PMID:35094408

Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds., PMID:35053363

Protective roles of liraglutide against brain injury of streptozotocin induced diabetic rats., PMID:35034872

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells., PMID:34842137

Genetic variants in splicing factor genes and susceptibility to bladder cancer., PMID:34673209

Subcellular localization of neuronal nuclei (NeuN) antigen in size and calcitonin gene-related peptide (CGRP) populations of dorsal root ganglion (DRG) neurons during acute peripheral inflammation., PMID:34146639

Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a., PMID:34109426

Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants., PMID:34039076

Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease., PMID:33649817

Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats., PMID:33631250

Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status., PMID:33421531

Remote Ischemic Postconditioning Inhibited Mitophagy to Achieve Neuroprotective Effects in the Rat Model of Cardiac Arrest., PMID:33409854

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human RBFOX3 Protein, N-His [YHA00601]
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