Catalog No.
DHE26201
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P40238
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
TA136, TA 136, TA-136
Clone ID
TA136
PF4 activates the c-Mpl-Jak2 pathway in platelets., PMID:37883794
Antibody targeting of mutant calreticulin in myeloproliferative neoplasms., PMID:37551061
Rituximab, methotrexate, procarbazine and lomustine (R-MPL) for the treatment of primary Central nervous system lymphoma., PMID:35491706
Treatment patterns in adults with immune thrombocytopenia before, during and after use of thrombopoietin receptor agonists: a longitudinal prescription database study from Germany., PMID:34547980
Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease-specific treatments: a French nationwide cohort study., PMID:34386974
The first report of allogeneic haematopoietic stem cell transplantations for bone marrow failure performed in Sri Lanka., PMID:33904187
How I treat primary ITP in adult patients who are unresponsive to or dependent on corticosteroid treatment., PMID:33827138
An escalating treatment strategy for children with severe chronic immune thrombocytopenia: Preliminary report from a single center., PMID:33720524
Romiplostim in adults with newly diagnosed or persistent immune thrombocytopenia., PMID:33249935
Clinical association between thyroid disease and immune thrombocytopenia., PMID:33165625
A phase 2 study of the bivalent VLP norovirus vaccine candidate in older adults; impact of MPL adjuvant or a second dose., PMID:32563606
Longitudinal evaluation of eltrombopag in paediatric acquired severe aplastic anaemia., PMID:32529633
Deficit of circulating CD19+ CD24hi CD38hi regulatory B cells in severe aplastic anaemia., PMID:32311088
Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists., PMID:31280643
A Case of Acquired Amegakaryocytic Thrombocytopenia with Anti-c-mpl Autoantibody: Comparison with Idiopathic Thrombocytopenic Purpura., PMID:31132762
Understanding how older age drives decision-making and outcome in Immune Thrombocytopenia. A single centre study on 465 adult patients., PMID:30408157
Autoimmune haemolytic anaemia and autoimmune thrombocytopenia in childhood-onset systemic lupus erythematosus: updates on pathogenesis and treatment., PMID:29979258
Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia., PMID:29532903
Thrombopoietin (TPO) induces thrombocytic colony formation of kidney cells synergistically with kit ligand A and a non-secretory TPO variant exists in common carp., PMID:29522790
A critical appraisal of the evidence for the role of splenectomy in adults and children with ITP., PMID:29479668
Affinity maturation of an TpoR targeting antibody in full-length IgG form for enhanced agonist activity., PMID:29474709
Splenectomy for immune thrombocytopenia: down but not out., PMID:29295846
Thrombocytopenia in pregnancy., PMID:29222249
Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection., PMID:29085203
Autoimmune Myelofibrosis: Clinical Features, Course, and Outcome., PMID:28866671
Acquired RhD mosaicism identifies fibrotic transformation of thrombopoietin receptor-mutated essential thrombocythemia., PMID:28653329
Beyond immune thrombocytopenia: the evolving role of thrombopoietin receptor agonists., PMID:28275823
Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage., PMID:27885890
Splenectomy in ITP: we keep removing a healthy functional organ., PMID:27577110
Eltrombopag: A Review in Paediatric Chronic Immune Thrombocytopenia., PMID:27151255
Thrombocytopenia and Anemia with Anti-c-Mpl antibodies Effectively Treated with Cyclosporine in a Patient with Rheumatoid Arthritis and Chronic Renal Failure., PMID:26984091
Thrombopoietin receptor agonists for preparing adult patients with immune thrombocytopenia to splenectomy: results of a retrospective, observational GIMEMA study., PMID:26910388
Monoclonal antibody 1.6.1 against human MPL receptor allows HSC enrichment of CB and BM CD34(+)CD38(-) populations., PMID:26733047
Turning Cancer Cells into Cancer Killers., PMID:26621762
Chronic lymphocytic leukemia and myeloproliferative neoplasms concurrently diagnosed: clinical and biological characteristics., PMID:26402369
Effect of a thrombopoietin receptor agonist on use of intravenous immune globulin in patients with immune thrombocytopenia., PMID:26400824
Integrated analysis of long-term safety in patients with chronic immune thrombocytopaenia (ITP) treated with the thrombopoietin (TPO) receptor agonist romiplostim., PMID:26201709
The association of rituximab and a thrombopoietin receptor agonist in high-risk refractory immune thrombocytopenic purpura., PMID:26057496
Identification of anti-thrombopoietin receptor antibody in prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation treated successfully with eltrombopag., PMID:25964100
The new thrombopoietic agenda: impact on leukemias and MDS., PMID:25455280
Eltrombopag as steroid sparing therapy for immune thrombocytopenic purpura in systemic lupus erythematosus., PMID:25416695
Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value., PMID:24618731
The biology of thrombopoietin and thrombopoietin receptor agonists., PMID:23821332
[Trombopag for chronic immune thrombocytopenia in a patient previously treated with romiplostim]., PMID:23789804
Novel anti-c-Mpl monoclonal antibodies identified multiple differentially glycosylated human c-Mpl proteins in megakaryocytic cells but not in human solid tumors., PMID:23750472
Idiopathic thrombocytopenic purpura resistant to eltrombopag, but cured with romiplostim., PMID:23736912
Management of primary immune thrombocytopenia, 2012: a survey of oklahoma hematologists-oncologists., PMID:23462246
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP)., PMID:23157319
Positioning new treatments in the management of immune thrombocytopenia., PMID:23109488
Combined romiplostim and intravenous immunoglobulin therapy increased platelet count, facilitating splenectomy in a patient with refractory immune thrombocytopenic purpura unresponsive to monotherapy., PMID:22758388
For research use only. Not for human or drug use.
