Catalog No.
DHC20402
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
Complement C2, C2, C3/C5 convertase
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P06681
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
ARGX-117, ARGX117, ARGX 117
Clone ID
ARGX-117
Is COVID-19 Coagulopathy a Thrombotic Microangiopathy? A Prospective, Observational Study., PMID:40508203
Serum Proteomic Markers in Patients with Systemic Sclerosis in Relation to Silica Exposure., PMID:40142826
Acute eculizumab treatment in a pediatric patient with AQP4-IgG+ NMOSD., PMID:39844619
Systemic Administration of a Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits and Neuroinflammation in Mice., PMID:39682736
Complement activation by IgM autoantibodies linked to immune-mediated neuropathies depends on C2., PMID:39545641
Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis., PMID:39125933
A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice., PMID:38597412
The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi., PMID:38552741
Humoral complementomics - exploration of noninvasive complement biomarkers as predictors of renal cancer progression., PMID:38487624
Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report., PMID:38469558
The Acquisition of Complement-Dependent Cytotoxicity by the Type II Anti-CD20 Therapeutic Antibody Obinutuzumab., PMID:38201478
Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development., PMID:38142429
Extracellular matrix turnover biomarkers reflect pharmacodynamic effects and treatment response of adalimumab in patients with axial spondyloarthritis-results from two randomized controlled trials., PMID:37626399
A distinct variant of the SzM protein of Streptococcus equi subsp. zooepidemicus recruits C1q independent of IgG binding and inhibits activation of the classical complement pathway., PMID:37450582
A nanobody-based complement inhibitor targeting complement component 2 reduces hemolysis in a complement humanized mouse model of autoimmune hemolytic anemia., PMID:37315680
Complement inhibition prevents glial nodal membrane injury in a GM1 antibody-mediated mouse model., PMID:36523267
Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia., PMID:36119042
Safety and Efficacy of the Bordetella bronchiseptica Vaccine Combined with a Vegetable Oil Adjuvant and Multi-Omics Analysis of Its Potential Role in the Protective Response of Rabbits., PMID:35890330
Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy., PMID:35740382
Genetic Variants of Complement Factor H Y402H (rs1061170), C2 R102G (rs2230199), and C3 E318D (rs9332739) and Response to Intravitreal Anti-VEGF Treatment in Patients with Exudative Age-Related Macular Degeneration., PMID:35630075
Screening for Immunodeficiencies in Children With Invasive Pneumococcal Disease: Six-year Experience From a UK Children's Hospital., PMID:35421038
Sutimlimab: First Approval., PMID:35412113
In Silico Designed Gain-of-Function Variants of Complement C2 Support Cytocidal Activity of Anticancer Monoclonal Antibodies., PMID:35267578
Complement activation prior to symptom onset in myeloperoxidase ANCA-associated vasculitis but not proteinase 3 ANCA associated vasculitis - A Swedish biobank study., PMID:35048784
Expression of immune-related genes as prognostic biomarkers for the assessment of osteosarcoma clinical outcomes., PMID:34916564
Gain-of-Function Mutations R249C and S250C in Complement C2 Protein Increase C3 Deposition in the Presence of C-Reactive Protein., PMID:34899688
Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy., PMID:34759020
Complement Inhibition Targeted to Injury Specific Neoepitopes Attenuates Atherogenesis in Mice., PMID:34651027
Epigallocatechin Gallate (EGCG) Promotes the Immune Function of Ileum in High Fat Diet Fed Mice by Regulating Gut Microbiome Profiling and Immunoglobulin Production., PMID:34616764
Consumption of complement in a 26-year-old woman with severe thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination., PMID:34592707
Increasing the efficacy and safety of a human complement inhibitor for treating post-transplant cardiac ischemia reperfusion injury by targeting to a graft-specific neoepitope., PMID:34334299
Immune-Related Urine Biomarkers for the Diagnosis of Lupus Nephritis., PMID:34281193
The enigma of complement activation in mixed cryoglobulinemia., PMID:34052180
Bovine neonate is deficient in innate immunity at birth., PMID:33640760
Increased serum bactericidal activity of autologous serum in C2 deficiency after vaccination against Haemophilus influenzae type b, and further support for an MBL-dependent C2 bypass mechanism., PMID:33509693
Selective decrease in complement C2 hemolytic activity is a sensitive marker for cryoglobulinemia and active disease in hepatitis C patients., PMID:33478873
The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies., PMID:33412597
A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury., PMID:33210808
C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice., PMID:33178202
ARGX-117, a therapeutic complement inhibiting antibody targeting C2., PMID:32926878
An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase., PMID:32769120
ST6Gal1 is up-regulated and associated with aberrant IgA1 glycosylation in IgA nephropathy: An integrated analysis of the transcriptome., PMID:32677771
Complement activation is associated with crescent formation in IgA nephropathy., PMID:32300880
Revisiting the complement system in systemic lupus erythematosus., PMID:32228236
Hereditary Deficiency of the Second Component of Complement: Early Diagnosis and 21-Year Follow-Up of a Family., PMID:32164349
Gain-of-function mutation in complement C2 protein identified in a patient with aHUS., PMID:32113979
The effect of dietary cecropin AD on intestinal health, immune response and disease resistance of juvenile turbot (Scophthalmus maximus L.)., PMID:32109613
The ancient Thracian endemic plant Haberlea rhodopensis Friv. and related species: A review., PMID:31676402
Brucellosis and chlamydiosis seroprevalence in goats at livestock-wildlife interface areas of Zimbabwe., PMID:31478733
For research use only. Not for human or drug use.
