Anti-Human C4d Polyclonal Antibody

Catalog No.

PHC45301

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C4 (Thr1021-Thr1330).

Target

CO4, Basic complement C4, Complement C4-B, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4B, CPAMD3

Concentration

2.66 mg/ml

Purification

Purified by antigen affinity column.

Accession

P0C0L5

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Kidney transplant arteriopathy revisited., PMID:40533723

Banff 2022 updated classification of renal allograft pathology., PMID:40484008

Tocilizumab-Based Treatment of Microvascular Inflammation in Kidney Transplant Recipients: A Retrospective Study., PMID:40454296

Complement factors as biomarkers in ANCA-associated vasculitis in remission., PMID:40440129

Chronic rejection models for vascularized composite tissue allotransplantation., PMID:40374749

Alloreactive adaptive natural killer cells in renal transplantation: potential contribution to allograft microvascular inflammation., PMID:40340029

Complement in Antibody-Mediated Rejection of the Kidney Graft: From Pathophysiology to Clinical Practice., PMID:40283639

Association of Ultrastructural Changes in Renal Allograft Biopsies With Diagnostic Elements of Antibody-Mediated Rejection and Graft Outcomes., PMID:40279545

Implementation of the in-house technique for the determination of donor-derived cell-free DNA in daily clinical practice: Experience from the Hospital Clinic of Barcelona., PMID:40210550

Microvascular inflammation in kidney allografts: New directions for patient management., PMID:40199388

Production and Functional Verification of 8-Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-Edited Donor Pigs for Xenotransplantation., PMID:40190036

Histologic and molecular features shared between antibody-mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis., PMID:40178007

The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential., PMID:40142268

The role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study., PMID:40095080

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers., PMID:40093011

Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation., PMID:40045390

The prognostic relevance of donor-specific antibodies in facial transplantation - A retrospective cohort study., PMID:40043533

Spatial transcriptomics of Glomerulo-centric antibody mediated rejection in renal transplants., PMID:39993695

Impact of Immunosuppressive Drug Concentrations on Microvascular Inflammation, Negative Donor-Specific Antibodies, and C4d-Negative Status in Kidney Transplant Recipients., PMID:39980440

Novel janus kinase 3 inhibitor ritlecitinib suppresses T and B cell responses to prevent acute cardiac allograft rejection in mice., PMID:39954912

Additional Diagnoses Other Than Rejection in the Kidney Allograft Biopsy: Pitfalls for Biopsy-based Transcript Diagnostics., PMID:39936135

Granulomatous Tubulointerstitial Nephritis as a Rare Cause of Allograft Failure: A Case Report., PMID:39866980

Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodies: a pilot study., PMID:39799292

Effectiveness of complement inhibitors against refractory antibody-mediated rejection of lung transplantation: Two clinical cases., PMID:39756547

Non-HLA Antibodies and the Risk of Antibody-mediated Rejection without Donor-specific Anti-HLA Antibodies After Lung Transplantation., PMID:39753490

[Early-onset antibody-mediated rejection with fever as the main manifestation after bilateral lung transplantation: a case report]., PMID:39653533

Re-Evaluating the Transplant Glomerulopathy Lesion-Beyond Donor-Specific Antibodies., PMID:39640250

Early and late antibody mediated rejection: Which game is the complement playing?, PMID:39591699

Consecutive disruption of intrahepatic bile ducts after ABO-incompatible living-donor re-liver transplantation: A case report., PMID:39556930

Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: Results of a prospective, multicenter cohort study., PMID:39505152

C1q-Fixing De Novo Donor Specific Antibodies in Therapeutic Management of Chronic Antibody-Mediated Rejection Postkidney Transplantation., PMID:39443200

Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor., PMID:39430184

Accurate Visualization of C4d Complement Fragment in Immunohistochemistry by C-Terminal Linear Neoepitope-Specific Antibodies., PMID:39408855

Circulating capsid-antibody-complexes (CACs) drive intrahepatic complement deposition and inform subclinical liver inflammation in chronic hepatitis B., PMID:39396554

Serotype 15C Streptococcus pneumoniae resistant to classical complement deposition and agglutination by polyclonal rabbit anti-capsular 15B sera., PMID:39368131

Defining the Etiology of Renal Allograft Dysfunction Using Banff 2019 Classification: Correlation with Post-Transplant Duration and Creatinine Levels-A Comprehensive Analysis of 200 Renal Biopsies at a Tertiary Care Medical Center Hospital., PMID:39360394

Human leukocyte antigen compatibility and incidence of donor-specific antibodies in pediatric liver transplant recipients., PMID:39351427

Early and Late Microvascular Inflammation Have Differing Etiological Causes and Clinical Expression., PMID:39344003

IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto's thyroiditis via the complement pathway., PMID:39316722

Natural history of chronic idiopathic neutropenia of the adult., PMID:39300133

The role of C4d and donor specific antibodies in face and hand transplantation-a systematic review., PMID:39291278

Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up., PMID:39267618

Contemporary review of IgA nephropathy., PMID:39188719

Diagnosis of autoimmune bullous dermatoses: Comparative analysis of immunohistochemical staining using C4d, C3d, IgG, and IgG4 in lesional tissues and perilesional frozen skin samples., PMID:39180885

Unique Lessons From the Natural Progression of Rejection in Human Uterine Allografts., PMID:39166465

Plasma exchange-sensitive syncytial glomerulopathy in a kidney transplant patient., PMID:39162815

C4d, rather than C3d and C5b-9, Is Associated with Graft Loss in Recurrent IgA Deposition after Kidney Transplantation., PMID:39154645

Virtual crossmatching reveals upregulation of placental HLA-Class II in chronic histiocytic intervillositis., PMID:39134702

The relationship of microvascular inflammation with antibody-mediated rejection in kidney transplantation., PMID:39084463

Utility of C4d Immunohistochemistry in the Diagnosis of Esophageal Pemphigus Vulgaris., PMID:39034277

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