Catalog No.
PHJ89701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human NOX1 (Trp418-Phe564).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
NADPH oxidase 1, NOX-1, 1.6.3.-, Mitogenic oxidase 1, MOX-1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NOH-1, NOX1, MOX1, NOH1
Purification
Purified by antigen affinity column.
Accession
Q9Y5S8
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
CD4+ T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α-Mediated Increases in Endothelial NADPH Oxidase 1., PMID:39907014
Inhibition of both NOX and TNF-α exerts substantial renoprotective effects in renal ischemia reperfusion injury rat model., PMID:38492877
Targeting of the NOX1/ADAM17 Enzymatic Complex Regulates Soluble MCAM-Dependent Pro-Tumorigenic Activity in Colorectal Cancer., PMID:38137406
Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress., PMID:37401647
Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer., PMID:37115489
Inhibition of IL-6 signaling prevents serum-induced umbilical cord artery dysfunction from patients with severe COVID-19., PMID:36737252
The diagnostic potential of novel biomarkers of hypertension in men., PMID:36457990
Bisphenol A: Potential Factor of Miscarriage in Women in the Context of the Phenomenon of Neutrophil Extracellular Traps., PMID:36181646
CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53., PMID:36061308
Blockade or deficiency of PD-L1 expression in intestinal allograft accelerates graft tissue injury in mice., PMID:34679256
NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis., PMID:33941325
Effect of NADPH oxidase inhibitors in an experimental retinal model of excitotoxicity., PMID:32916159
NADPH oxidase 1 is highly expressed in human large and small bowel cancers., PMID:32428030
C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling., PMID:32122792
Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins., PMID:31919083
Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2., PMID:31689440
Bazedoxifene Ameliorates Homocysteine-Induced Apoptosis via NADPH Oxidase-Interleukin 1β and 6 Pathway in Osteocyte-like Cells., PMID:31250042
Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor-based immunotherapy., PMID:31249132
Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide., PMID:31076004
Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation., PMID:30867238
Epigallocatechin-3-Gallate Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis via Suppression of Oxidant Stress and Apoptosis by Targeting Hypoxia-Inducible Factor-1α/ Angiopoietin-Like 4 Pathway., PMID:30840953
Involvement of NADPH oxidase 1 in UVB-induced cell signaling and cytotoxicity in human keratinocytes., PMID:29872728
Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation., PMID:28504688
IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species., PMID:28477473
The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori., PMID:27048452
Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia., PMID:26761793
Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells., PMID:26760964
Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension., PMID:25712370
Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis., PMID:25517730
Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice., PMID:25014110
Characterization of N-glycosylation sites on the extracellular domain of NOX1/NADPH oxidase., PMID:24361341
Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress., PMID:23497312
Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects., PMID:23374164
Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1., PMID:23087362
Inhibitory effect of selaginellin on high glucose-induced apoptosis in differentiated PC12 cells: role of NADPH oxidase and LOX-1., PMID:22964466
[TNFR-Fc prevents lipopolysaccharide-induced acute lung injury in mice via oxidative stress inhibition]., PMID:22931725
Expression of NADPH oxidase and production of reactive oxygen species in aorta in an active immunization mouse model with AT1-EC2 peptide., PMID:22886959
Tumor cell-protective catalase as a novel target for rational therapeutic approaches based on specific intercellular ROS signaling., PMID:22753718
Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18., PMID:22636674
Regulation of NADPH oxidase gene expression with PKA and cytokine IL-4 in neurons and microglia., PMID:22565378
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4., PMID:21343298
Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition., PMID:20606112
Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene B4 receptor 2-linked pathway, contributing to angiogenesis., PMID:20194723
Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines., PMID:19732064
The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing., PMID:19536508
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation., PMID:19150879
NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression., PMID:20375612
Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6., PMID:18454176
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras., PMID:18398843
Overexpression of human NOX1 complex induces genome instability in mammalian cells., PMID:17963706
For research use only. Not for human or drug use.
