Anti-HIF1A Polyclonal Antibody

Catalog No.

PHH34301

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HIF1A (Asp55-Val342).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, IF:1:50-1:100, WB: 1:1000-1:4000

Target

Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8

Concentration

1.01 mg/ml

Purification

Purified by antigen affinity column.

Accession

Q16665

Applications

ELISA, IHC, IF, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1., PMID:40335899

Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells., PMID:40149887

Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis., PMID:40055343

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis., PMID:40054467

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, FG4592, Induces Endogenous Metallothionein3 Expression in Human Neuronal Cell Line, ReNcell CX Cells., PMID:39993744

Upshot of Some Bioactive Compounds on Angiogenesis in Retinal Pigment Epithelial Cells., PMID:39753522

Impact of anti-PD1 immunotherapy and circulating tumor cells on progression-free survival in surgical pancreatic adenocarcinoma: a retrospective cohort study., PMID:39745065

Oral exposure to ovalbumin alters glucose metabolism in sensitized mice: upregulation of HIF-1α-mediated glycolysis., PMID:39711353

ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner., PMID:39690180

Metabolic rewiring controlled by HIF-1α tunes IgA-producing B-cell differentiation and intestinal inflammation., PMID:39543372

Inhibition of Bruton's tyrosine kinase with PD-1 blockade modulates T cell activation in solid tumors., PMID:39513363

Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor., PMID:39482116

Anti-VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis., PMID:39462847

MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer., PMID:39436710

Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1α to exacerbate rheumatoid arthritis., PMID:39107082

A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention., PMID:39028915

Antioxidant effect of gallic acid on retinal ganglion cells in glaucoma model., PMID:38942959

CAFs-Associated Genes (CAFGs) in Pancreatic Ductal Adenocarcinoma (PDAC) and Novel Therapeutic Strategy., PMID:38892190

Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168

Ze-Qi-Tang formula inhibits MDSCs glycolysis through the down-regulation of p21/Hif1α/Glut1 signal in psoriatic-like mice., PMID:38810554

Epstein-Barr virus causes vascular abnormalities in epithelial malignancies through upregulating ANXA3-HIF-1α-VEGF pathway., PMID:38778160

Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling., PMID:38770916

Polyphyllin I ameliorates gefitinib resistance and inhibits the VEGF/VEGFR2/p38 pathway by targeting HIF-1a in lung adenocarcinoma., PMID:38761523

CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration., PMID:38715141

Effect of hypoxia-inducible factor-1 alpha expression on survival in patients with metastatic cervical squamous cell carcinoma treated with first-line chemotherapy and bevacizumab., PMID:38447002

Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling., PMID:38165930

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism., PMID:38162675

Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer., PMID:38092743

Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α., PMID:37800625

MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice., PMID:37689231

MT1-MMP as a Key Regulator of Metastasis., PMID:37681919

Analysis of microRNA expression in rat kidneys after VEGF inhibitor treatment under different degrees of hypoxia., PMID:37642276

In Silico Evaluation of HN-N07 Small Molecule as an Inhibitor of Angiogenesis and Lymphangiogenesis Oncogenic Signatures in Non-Small Cell Lung Cancer., PMID:37509650

HIF-1α/MMP-9 promotes spinal cord central sensitization in rats with bone cancer pain., PMID:37356787

IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming., PMID:37257765

LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis., PMID:36827886

Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity., PMID:36759727

Newly identified form of phenotypic plasticity of cancer: immunogenic mimicry., PMID:36754910

Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis., PMID:36602546

Heme oxygenase-1 protects against PM2.5 induced endothelial dysfunction through inhibition of HIF1α., PMID:36427673

GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization., PMID:36347996

A novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia., PMID:36016656

Cyclosporine A Modulates LSP1 Protein Levels in Human B Cells to Attenuate B Cell Migration at Low O2 Levels., PMID:36013463

CRMP2 derived from cancer associated fibroblasts facilitates progression of ovarian cancer via HIF-1α-glycolysis signaling pathway., PMID:35927239

HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression., PMID:35848884

Human organ rejuvenation by VEGF-A: Lessons from the skin., PMID:35749494

The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia., PMID:35306530

Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues., PMID:35239514

Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis., PMID:35231032

Changes in colostrum ingredients of Hu sheep, as well as the missense mutation genes associated with colostrum yield., PMID:35196466

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