Catalog No.
PHD32001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TSPAN8 (Lys110-Asn205).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Tetraspanin-8, Tspan-8, Transmembrane 4 superfamily member 3, Tumor-associated antigen CO-029, TSPAN8, TM4SF3
Purification
Purified by antigen affinity column.
Accession
P19075
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
TSPAN8+ myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer., PMID:38569015
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants., PMID:36827975
Tetraspanin-enriched Microdomain Containing CD151, CD9, and TSPAN 8 - Potential Mediators of Entry and Exit Mechanisms in Respiratory Viruses Including SARS-CoV-2., PMID:36173052
EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription., PMID:35197608
Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice., PMID:34498099
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator., PMID:34100012
Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner., PMID:32455575
TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy., PMID:32138170
Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029., PMID:30769765
Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer., PMID:28423546
Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer., PMID:27343445
Therapeutic targeting of tetraspanin8 in epithelial ovarian cancer invasion and metastasis., PMID:26804173
Generation of a human antibody that inhibits TSPAN8-mediated invasion of metastatic colorectal cancer cells., PMID:26562525
Effect of an anti-human Co-029/tspan8 mouse monoclonal antibody on tumor growth in a nude mouse model., PMID:25285080
Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury., PMID:24926311
Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line., PMID:22073229
Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility., PMID:20937409
E-cadherin/p120-catenin and tetraspanin Co-029 cooperate for cell motility control in human colon carcinoma., PMID:20858717
Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029., PMID:16849554
Profiling of the tetraspanin web of human colon cancer cells., PMID:16467180
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells., PMID:15725074
The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation., PMID:13130099
Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy., PMID:9531564
Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens., PMID:2395876
For research use only. Not for human or drug use.
