Catalog No.
PHB07801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ADAM23 (Met107-Gly489).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3, ADAM23, MDC3
Purification
Purified by antigen affinity column.
Accession
O75077
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Case Report: Anti-ADAM23 antibody: an overlooked autoantibody against VGKC-complex in autoimmune encephalitis., PMID:40519920
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway., PMID:40455867
Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts., PMID:39454566
Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission., PMID:38700985
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity., PMID:38194969
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms., PMID:32437528
ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents., PMID:30965109
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory., PMID:30346486
Monoclonal Antibody DL11C8 Identifies ADAM23 as a Component of Lipid Raft Microdomains., PMID:29792904
Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor., PMID:27317750
In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression., PMID:27095822
ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells., PMID:26800504
Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors., PMID:24227725
Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development., PMID:21786032
Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series., PMID:20580615
Association and interaction analyses of eight genes under asthma linkage peaks., PMID:19824886
ADAM23 is a cell-surface glycoprotein expressed by central nervous system neurons., PMID:15505805
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism., PMID:10749942
MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes., PMID:10506182
For research use only. Not for human or drug use.
