Catalog No.
PHB03601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human RAMP1 (Cys27-Leu119).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Receptor activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1, RAMP1
Purification
Purified by antigen affinity column.
Accession
O60894
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling., PMID:39376604
Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury., PMID:38970101
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein., PMID:38603770
Characteristics associated with response to subcutaneously administered anti-CGRP monoclonal antibody medications in a real-world community cohort of persons living with migraine: A retrospective clinical and genetic study., PMID:38071464
The Anti-Calcitonin Gene-Related Peptide (Anti-CGRP) Antibody Fremanezumab Reduces Trigeminal Neurons Immunoreactive to CGRP and CGRP Receptor Components in Rats., PMID:37686275
Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors., PMID:37580864
Response to erenumab assessed by Headache Impact Test-6 is modulated by genetic factors and arterial hypertension: An explorative cohort study., PMID:36627267
Gel-forming antagonist provides a lasting effect on CGRP-induced vasodilation., PMID:36569288
Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale., PMID:36555690
Procalcitonin mediates vascular dysfunction in obesity., PMID:35998685
Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists., PMID:35822594
Virtual drug repurposing study for the CGRPR identifies pentagastrin and leuprorelin as putative candidates., PMID:35803082
CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons., PMID:35620595
Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor., PMID:35614383
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?, PMID:35136961
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice., PMID:35115501
IMD/ADM2 operates as a secretory factor that controls cumulus-oocyte complexes (COCs) conformation for oocytes in vitro maturation., PMID:35102467
Clinic and genetic predictors in response to erenumab., PMID:34965002
Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division., PMID:34611305
CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine., PMID:34407650
CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists?, PMID:34076887
Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy., PMID:33489885
The Effects of Calcitonin Gene-Related Peptide on Bone Homeostasis and Regeneration., PMID:33030684
Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion., PMID:32086679
Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab)., PMID:32049005
C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system., PMID:31718551
Sex differences in the expression of calcitonin gene-related peptide receptor components in the spinal trigeminal nucleus., PMID:31223141
Development of chimeric and bifunctional antagonists for CLR/RAMP receptors., PMID:31150417
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma., PMID:30741933
Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies., PMID:30689083
CGRP Antibodies as Prophylaxis in Migraine., PMID:30550780
The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects., PMID:30283343
Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome., PMID:29642930
Is the activity of CGRP and Adrenomedullin regulated by RAMP (-2) and (-3) in Trypanosomatidae? An in-silico approach., PMID:29626675
Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension., PMID:29297736
Recognizing the role of CGRP and CGRP receptors in migraine and its treatment., PMID:29020807
Distribution of CGRP and its receptor components CLR and RAMP1 in the rat retina., PMID:28603014
The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine., PMID:28485848
Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy., PMID:28375666
Induction of Migraine-Like Photophobic Behavior in Mice by Both Peripheral and Central CGRP Mechanisms., PMID:28053042
Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies., PMID:27155150
Mapping the calcitonin receptor in human brain stem., PMID:26911465
Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence, and autoradiography., PMID:26105175
CGRP as a neuropeptide in migraine: lessons from mice., PMID:26032833
Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line., PMID:24454825
Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment., PMID:24004534
CGRP receptor antagonism and migraine therapy., PMID:23745702
CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4., PMID:23731651
Novel pathways in the pathobiology of human abdominal aortic aneurysms., PMID:22797469
Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice., PMID:22563471
For research use only. Not for human or drug use.
