Catalog No.
PHA76301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TRAF3IP2 (Ser403-Arg554).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
E3 ubiquitin ligase TRAF3IP2, 2.3.2.27, Adapter protein CIKS, Connection to IKK and SAPK/JNK, E3 ubiquitin-protein ligase CIKS, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6
Purification
Purified by antigen affinity column.
Accession
O43734
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Detection of selection signatures for response to Aleutian mink disease virus infection in American mink., PMID:33536540
The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion., PMID:33160017
The differential response to anti IL-6 treatment in COVID-19: the genetic counterpart., PMID:32452345
Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury., PMID:32335141
Improvement of Psoriasis by Alteration of the Gut Environment by Oral Administration of Fucoidan from Cladosiphon Okamuranus., PMID:32164223
MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling., PMID:30892082
STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren's Syndrome: Association with Disease Susceptibility and Clinical Aspects., PMID:30882006
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3., PMID:30013031
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling., PMID:27980343
Increased Act1/IL-17R expression in Hirschsprung's disease., PMID:27660002
Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis., PMID:27564082
Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis., PMID:27342690
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway., PMID:26937622
Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome., PMID:26830368
Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease., PMID:26558270
Development and validation of receptor occupancy pharmacodynamic assays used in the clinical development of the monoclonal antibody vedolizumab., PMID:25908521
Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice., PMID:23904159
The role of Act1, a NF-κB-activating protein, in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells., PMID:23862741
Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis., PMID:23123062
Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease., PMID:22585710
IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner., PMID:22511335
The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody., PMID:20662069
An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene., PMID:20660351
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency., PMID:20652909
IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16., PMID:20139273
Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome., PMID:18624351
Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling., PMID:18061473
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease., PMID:17277779
Remodeling of organelle-bound actin is required for yeast vacuole fusion., PMID:12177043
A sigma(54) activator protein necessary for spore differentiation within the fruiting body of Myxococcus xanthus., PMID:10762243
For research use only. Not for human or drug use.
