Catalog No.
YMC36901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gly33-Thr310
Predicted molecular weight
33.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22272
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, CD126, Soluble interleukin-6 receptor subunit alpha, sIL6R, Il6ra, Il6r
IL-6R Signaling Is Associated with PAD4 and Neutrophil Extracellular Trap Formation in Patients with STEMI., PMID:40508157
Damage Associated Molecular Patterns (DAMPs) Mediate the Foreign Body Response to Poly(ethylene glycol) Diacrylate Hydrogels via Toll like Receptors., PMID:40504683
Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression., PMID:40487749
Multi-omics interpretation of how lysophospholipids regulate hepatic lipid metabolism and immunity in hybrid grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus Lanceolatu) fed high-lipid diets., PMID:40487090
Gallic acid suppresses esophageal squamous cell carcinoma progression and enhances cisplatin chemosensitivity through IL-6/STAT3/Notch pathway., PMID:40486873
Comparative transcriptomic and molecular interaction analysis of olive polyphenols: Unraveling their mechanisms in immune regulation and metabolic processes in adipocytes., PMID:40483856
CD44-downregulation in multiple myeloma inhibits cytoskeleton rearrangement through actin depolymerization., PMID:40481899
Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel therapeutic avenues., PMID:40474229
Preparation, unique structural characteristics and immunomodulatory effects of peptides from Antarctic krill (Euphausia superba)., PMID:40467199
JAG2 AS A KEY MEDIATOR IN PORPHYROMONAS GINGIVALIS-INDUCED PERIODONTAL INFLAMMATION., PMID:40466700
FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK-mTOR Signaling Pathway., PMID:40464505
Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:40464469
IL-6R blockade combined with immunosuppressants alleviates adult-onset Still's disease through immune remodeling: a mass cytometry study., PMID:40457438
Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-κB/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation., PMID:40453349
Neuronal hyperexcitability in dystrophin-deficient mdx hippocampal neurons: the importance of interleukin-6 and GABAergic regulation., PMID:40447687
GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells., PMID:40442782
Role of NLRC3 in modulating inflammatory responses in neonates., PMID:40437402
Essential oil-derived compounds target core fatigue-related genes: A network pharmacology and molecular Docking approach., PMID:40435272
Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization., PMID:40434345
IL-10 and IL-6/IL-10 as predictive biomarkers for treatment response in non-infectious uveitis., PMID:40433375
LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice., PMID:40427591
Highly elevated sepsis biomarkers in advanced cholangiocarcinoma without sepsis: A case report and literature review., PMID:40419900
Presepsin in the amniotic fluid is a useful clinical inflammatory biomarker for the prenatal predictive diagnosis of histologic chorioamnionitis: a retrospective preliminary study., PMID:40413908
Integrative genome-wide association studies, proteome-wide Mendelian randomization, and single-cell RNA sequencing identify interleukin-6 receptor protein as a therapeutic target in aortic aneurysm., PMID:40409638
Anti-IL-6R antibody treatment changes microglial phenotype in AQP4 peptide-immunized mice, leading to suppression of myelitis severity., PMID:40403514
Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner., PMID:40403091
Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway., PMID:40396181
Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus., PMID:40374862
Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement., PMID:40373041
Evaluation of CRP SNV rs2808630 and acute proinflammatory biomarkers in patients with CKD and PLHIV with CKD: a case-control study., PMID:40369487
FokI polymorphism of the vitamin D receptor gene: Linking COVID-19 risk to genetic susceptibility in children., PMID:40367829
Escherichia coli aggravates inflammatory response in mice oral mucositis through regulating Th17/Treg imbalance., PMID:40365536
Anti-IL-6 receptor antibody suppresses onset of paralytic symptoms in AQP4 peptide-immunized mice without lowering bone strength or mineral density., PMID:40359583
Study of some biological markers in cord blood of preterm and term infants and their association with neonatal sepsis., PMID:40353384
Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study., PMID:40348744
Palmitic acid and lipopolysaccharide induce macrophage TNFα secretion, suppressing browning regulators and mitochondrial respiration in adipocytes., PMID:40348028
High local type-2 inflammation is linked to response in severe asthma treated with anti-Interleukin-5 receptor., PMID:40345261
Effects and Mechanisms of Paeoniflorin in Relieving Neuropathic Pain: Network Pharmacological Analysis and Experimental Validation., PMID:40343651
Contezolid, a novel oxazolidinone antibiotic, acts as a potential anti-inflammatory agent., PMID:40341835
Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase., PMID:40339440
The effect of eight different gene polymorphisms on osteopenia and osteoporosis in the Turkish population., PMID:40332270
Interleukin-6 in neuroimmunological disorders: Pathophysiology and therapeutic advances with satralizumab., PMID:40324548
Neutrophil Z Is a Novel Marker to Differentiate Disease Flares From Bacterial Infections in Febrile SLE Patients., PMID:40302194
Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma., PMID:40288207
Anxiety-like behavior in rats during periods of abstinence following E-cigarette vapor and cigarette smoke exposure: Role of inflammatory cytokines and glutamate receptors., PMID:40287018
Impact of resistance training on inflammatory biomarkers and associations with treatment outcomes in colon cancer., PMID:40278841
The Circadian Clock Component REV-ERB Is an Analgesic Target for Cancer-Induced Tactile Pain Hypersensitivity., PMID:40268481
Activation and targetability of TYMP-IL-6-TF signaling in the skin microenvironment in uremic calciphylaxis., PMID:40267216
For research use only. Not for human or drug use.
