Catalog No.
YHN52601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala21-Arg299
Predicted molecular weight
33.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92874
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deoxyribonuclease-1-like 2, 3.1.21.-, DNase I homolog protein DHP1, Deoxyribonuclease I-like 2, DNase I-like 2, DNASE1L2, DHP1, DNAS1L2
Transcriptional differences between vesicular hand eczema and atopic dermatitis., PMID:37857578
Identification and verification of a prognostic signature based on a miRNA-mRNA interaction pattern in colon adenocarcinoma., PMID:37745305
Origin and significance of the human DNase repertoire., PMID:35725583
Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease., PMID:33802146
DNASE1L2, as a Carcinogenic Marker, Affects the Phenotype of Breast Cancer Cells Via Regulating Epithelial-Mesenchymal Transition Process., PMID:32343605
Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses., PMID:28928425
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis., PMID:28743926
Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis., PMID:28394916
Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells., PMID:28127892
AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation., PMID:26045045
Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes., PMID:25576224
Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: microarray analysis., PMID:23235115
Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity., PMID:23161465
Mechanisms and emerging functions of DNA degradation in the epidermis., PMID:22652792
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails., PMID:21307874
Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes., PMID:20967767
Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes., PMID:20503202
Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression., PMID:17490414
DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus., PMID:17459041
DNase1L2 degrades nuclear DNA during corneocyte formation., PMID:16902420
Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines., PMID:15203207
Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis., PMID:11141064
Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I., PMID:9205125
For research use only. Not for human or drug use.
