Catalog No.
PHJ69801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ADA2 (Ile30-Lys511).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Adenosine deaminase 2,IDGFL,ADGF,ADA2,Cat eye syndrome critical region protein 1,CECR1
Purification
Purified by antigen affinity column.
Accession
Q9NZK5
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Genome and transcriptome sequencing for inborn errors of immunity: a feasible multi-omics diagnostic approach., PMID:40226629
Highlights from the breakout session: vasculitis in paediatric rheumatology., PMID:40071400
Deficiency of adenosine deaminase 2 skews adaptive immune repertoires toward specific sets of T- and B-cell receptors., PMID:39924119
Immunodeficiency in children with Diamond Blackfan and Diamond Blackfan like anemia., PMID:39923319
Deficiency of adenosine deaminase 2 (DADA2) with bilateral renal subcapsular hematoma: a case report and literature review., PMID:39239002
ADA-2 gene mutation in a Crohn's disease patient without response to therapy., PMID:38554426
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers., PMID:38512356
Sudden unexpected death of a young adult due to subarachnoid hemorrhage associated with polyarteritis nodosa: Clinicopathological appearance and literature review., PMID:38072093
Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency., PMID:36159847
Inflammatory diseases in hematology: a review., PMID:35938681
Lentiviral Mediated ADA2 Gene Transfer Corrects the Defects Associated With Deficiency of Adenosine Deaminase Type 2., PMID:35529868
Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study., PMID:34975878
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies., PMID:34140538
Biochemical characterization of adenosine deaminase (CD26; EC 3.5.4.4) activity in human lymphocyte-rich peripheral blood mononuclear cells., PMID:34037096
Deficiency of adenosine deaminase 2 diagnosed at 65 years of age., PMID:33676630
ADA2 deficiency (DADA2) associated with Evans syndrome and a severe ADA2 genotype., PMID:33493352
Successful treatment with cyclosporine and anti-tumour necrosis factor agent for deficiency of adenosine deaminase-2., PMID:32720851
Late-Onset EBV Susceptibility and Refractory Pure Red Cell Aplasia Revealing DADA2., PMID:32643137
Clusters in Pediatric Rheumatic Diseases., PMID:32436006
ADA2 deficiency complicated by EBV-driven lymphoproliferative disease., PMID:32353633
Heterogeneity of Liver Disease in Common Variable Immunodeficiency Disorders., PMID:32184784
[ADA2 deficit: a case with neurological manifestations as a predominant clinic]., PMID:32149384
Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis., PMID:31008556
Treatment Strategies for Deficiency of Adenosine Deaminase 2., PMID:30995379
A synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs., PMID:30804216
ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation., PMID:30692987
Adenosine Deaminase Two and Immunoglobulin M Accurately Differentiate Adult Sneddon's Syndrome of Unknown Cause., PMID:30645994
A 9.5-year-old boy with recurrent neurological manifestations and severe hypertension, treated initially for polyarteritis nodosa, was subsequently diagnosed with adenosine deaminase type 2 deficiency (DADA2) which responded to anti-TNF-α., PMID:30642227
Warts and DADA2: a Mere Coincidence?, PMID:30386947
Renal Amyloidosis in Deficiency of Adenosine Deaminase 2: Successful Experience With Canakinumab., PMID:30377239
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2., PMID:30224453
Severe and Refractory Polyarteritis Nodosa Associated With CECR1 Mutation and Dramatic Response to Infliximab in Adulthood., PMID:29916967
Adenosine Deaminase Activity and HLA-DRB as Diagnostic Markers for Rheumatoid Arthritis., PMID:29623847
"Immune" Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant: Implication on Differential Diagnostics of ITP in Children., PMID:29620681
Deficiency of Adenosine Deaminase 2 (DADA2), an Inherited Cause of Polyarteritis Nodosa and a Mimic of Other Systemic Rheumatologic Disorders., PMID:28983775
Autoimmune phenotype with type I interferon signature in two brothers with ADA2 deficiency carrying a novel CECR1 mutation., PMID:28830446
ADA2 deficiency (DADA2) as an unrecognised cause of early onset polyarteritis nodosa and stroke: a multicentre national study., PMID:28522451
Screening of 181 Patients With Antibody Deficiency for Deficiency of Adenosine Deaminase 2 Sheds New Light on the Disease in Adulthood., PMID:28493328
Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency., PMID:26922074
Genetics of vasculitis., PMID:25405820
Potential roles of adenosine deaminase-2 in diabetic retinopathy., PMID:23685153
Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen: correlation with IFN-gamma and cytolytic activity by CD8+ T cells., PMID:18588933
Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila., PMID:16428443
Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity., PMID:15926889
PfADA2, a Plasmodium falciparum homologue of the transcriptional coactivator ADA2 and its in vivo association with the histone acetyltransferase PfGCN5., PMID:15246536
Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling., PMID:15075257
Two different Drosophila ADA2 homologues are present in distinct GCN5 histone acetyltransferase-containing complexes., PMID:12482983
Adenosine deaminase isoenzyme levels in patients with human T-cell lymphotropic virus type 1 and human immunodeficiency virus type 1 infections., PMID:8548545
In vitro regulation of thyroglobulin (Tg) autoantibody production by Tg-specific T-cell lines and hybridomas., PMID:1717368
For research use only. Not for human or drug use.
