Catalog No.
PHJ67401
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CISH (Met1-Leu258).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CIS-1,CIS,SOCS,Cytokine-inducible SH2-containing protein,CISH,Protein G18,Suppressor of cytokine signaling,G18
Purification
Purified by antigen affinity column.
Accession
Q9NSE2
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Integration of Chromogenic RNAscope In Situ Hybridization for Target Validation in Drug Discovery., PMID:39829073
Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling., PMID:39605016
Xianling Lianxia formula improves the efficacy of trastuzumab by enhancing NK cell-mediated ADCC in HER2-positive BC., PMID:39493309
Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases., PMID:37641429
HER2 Status in RAS and BRAF Wild-Type Metastatic Colorectal Cancer: A Portuguese Study., PMID:37637599
HER2 Expression in Peritoneal Dissemination of High-Grade Serous Ovarian Carcinoma: A Comparative Study of Immunohistochemical Reactivity Using Four HER2 Antibodies., PMID:36498537
[Enhanced Natural Killers with CISH and B2M Gene Knockouts Reveal Increased Cytotoxicity in Glioblastoma Primary Cultures]., PMID:36165021
TGFβ and CIS Inhibition Overcomes NK-cell Suppression to Restore Antitumor Immunity., PMID:35759796
Use of Ultrasensitive RNA In Situ Hybridization for Determining Clonality in Cutaneous B-Cell Lymphomas and Lymphoid Hyperplasia Decreases Subsequent Use of Molecular Testing and Is Cost-effective., PMID:35067516
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH., PMID:34571899
CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone., PMID:34290377
Chromogenic In Situ Hybridization (CISH) as a Method for Detection of C-Myc Amplification in Formalin-Fixed Paraffin-Embedded Tumor Tissue: An Update., PMID:34019299
Deep learning identifies morphological features in breast cancer predictive of cancer ERBB2 status and trastuzumab treatment efficacy., PMID:33597560
Juvenile-Onset Recurrent Respiratory Papillomatosis Aggressiveness: In Situ Study of the Level of Transcription of HPV E6 and E7., PMID:33019611
Working together for the family: determination of HER oncogene co-amplifications in breast cancer., PMID:32733648
Chromogenic in situ hybridization for the detection of lambda and kappa immunoglobulin light chains as a potential auxiliary diagnostic technique in canine plasmacytomas., PMID:32627692
Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype., PMID:32207245
Association between PD-L1 expression and driver gene mutations in non-small cell lung cancer patients: correlation with clinical data., PMID:31989260
The transcriptional response of mouse spleen B cells to IL-4: Comparison to the response of human peripheral blood B cells., PMID:30302405
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways., PMID:28792938
Primary CNS Nonamyloidogenic Light Chain Deposition Disease: Case Report and Brief Review., PMID:28669250
Chromosome 7 Multiplication in EGFR-positive Lung Carcinomas Based on Tissue Microarray Analysis., PMID:28652432
Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis., PMID:28344878
mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α., PMID:27256566
The role of p95HER2 in trastuzumab resistance in breast cancer., PMID:27273948
Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy., PMID:27037253
Chromogenic In Situ Hybridisation Test for Breast Cancer Patients with Equivocal IHC Results--a Study from Iran., PMID:26625783
[THE TECHNOLOGY "CELL BLOCK" IN CYTOLOGICAL PRACTICE]., PMID:26596046
Comparison of methods in the detection of ALK and ROS1 rearrangements in lung cancer., PMID:25789833
EPSTEIN -BARR VIRUS ASSOCIATION WITH MALIGNANT LYMPHOMA SUBGROUPS IN ZARIA, NIGERIA., PMID:25620871
Synthesis, physicochemical and biological evaluation of technetium-99m labeled lapatinib as a novel potential tumor imaging agent of Her-2 positive breast cancer., PMID:25440878
Detection of immunoglobulin light-chain restriction in cutaneous B-cell lymphomas by ultrasensitive bright-field mRNA in situ hybridization., PMID:25363373
Human leptospirosis: seroreactivity and genetic susceptibility in the population of São Miguel Island (Azores, Portugal)., PMID:25255143
Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas., PMID:25188507
Kappa and lambda light chain mRNA in situ hybridization compared to flow cytometry and immunohistochemistry in B cell lymphomas., PMID:25047073
Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase., PMID:24791876
HER2/CHR 17 tissue microarray chromogenic in situ hybridization analysis in colon adenocarcinoma: multiple gene signals vs protein expression., PMID:24659651
Intratumoral distribution of EGFR-amplified and EGFR-mutated cells in pulmonary adenocarcinoma., PMID:24355440
Evidence of association of human papillomavirus with prognosis worsening in glioblastoma multiforme., PMID:24285549
FGFR signalling in women's cancers., PMID:24148254
Ultrasensitive RNA in situ hybridization for detection of restricted clonal expression of low-abundance immunoglobulin light chain mRNA in B-cell lymphoproliferative disorders., PMID:24124155
Combined HER2 analysis of biopsies and surgical specimens to optimize detection of trastuzumab-eligible patients in eso-gastric adenocarcinoma: a GERCOR study., PMID:24114855
Detection of c-myc amplification in formalin-fixed paraffin-embedded tumor tissue by chromogenic in situ hybridization (CISH)., PMID:24006070
The HER2 CISH pharmDx(™) Kit in the assessment of breast cancer patients for anti-HER2 treatment., PMID:23570400
Assessment of protein expression and gene status of human epidermal growth factor receptor (HER) family molecules in ameloblastomas., PMID:23278525
Evaluation of reliability of FISH versus brightfield dual-probe in situ hybridization (BDISH) for frontline assessment of HER2 status in breast cancer samples in a community setting: influence of poor tissue preservation., PMID:22982892
mRNA in situ hybridization (HistoSonda): a new diagnostic tool for HER2-status in breast cancer-a multicentric Spanish study., PMID:22555091
Immunoglobulin heavy-chain fluorescence in situ hybridization-chromogenic in situ hybridization DNA probe split signal in the clonality assessment of lymphoproliferative processes on cytological samples., PMID:22517675
Tubular and endothelial chimerism in renal allografts using fluorescence and chromogenic in situ hybridization (FISH, CISH) technology., PMID:22449229
Impact of HER2 and PTEN simultaneous deregulation in non-small cell lung carcinoma: correlation with biological behavior., PMID:23464451
For research use only. Not for human or drug use.
