Anti-NOX4 Polyclonal Antibody

Catalog No.

PHJ63501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NOX4 (Gly210-Glu424).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

RENOX,NOX4,Renal NAD(P)H-oxidase,NADPH oxidase 4,Kidney oxidase-1,Kidney superoxide-producing NADPH oxidase,KOX-1

Purification

Purified by antigen affinity column.

Accession

Q9NPH5

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy., PMID:40306394

Examining the Relationship Between Polystyrene Microplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture., PMID:39376189

Targeting TGF-β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica., PMID:39234801

Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation., PMID:37649607

Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition., PMID:37628676

Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress., PMID:37401647

Histological and biochemical evaluation of the effects of silver nanoparticles (AgNps) versus titanium dioxide nanoparticles (TiO2NPs) on rat parotid gland., PMID:37132546

VEGF-A: A Novel Mechanistic Link Between CYP2C-Derived EETs and Nox4 in Diabetic Kidney Disease., PMID:36662655

Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem Biopsies., PMID:36361818

Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin., PMID:36205057

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury., PMID:35806094

NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model., PMID:35346198

eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis., PMID:35167418

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria., PMID:35029280

Artificial Neural Network Analysis-Based Immune-Related Signatures of Primary Non-Response to Infliximab in Patients With Ulcerative Colitis., PMID:34992592

Di-Tyrosine Crosslinking and NOX4 Expression as Oxidative Pathological Markers in the Lungs of Patients with Idiopathic Pulmonary Fibrosis., PMID:34829703

Free Radical-Mediated Protein Radical Formation in Differentiating Monocytes., PMID:34576127

NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells., PMID:34209278

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253

Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis., PMID:33916948

Inhibition of Cochlear HMGB1 Expression Attenuates Oxidative Stress and Inflammation in an Experimental Murine Model of Noise-Induced Hearing Loss., PMID:33916471

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment., PMID:33777671

Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy., PMID:33537085

Micellar Casein and Whey Powder Hold a TGF-β Activity and Regulate ID Genes In Vitro., PMID:33477984

TGF-β Activity of a Demineralized Bone Matrix., PMID:33440877

Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase., PMID:33079994

Differential effects of risuteganib and bevacizumab on AMD cybrid cells., PMID:33075294

CD248 as a novel therapeutic target in pulmonary arterial hypertension., PMID:32997414

TGF-β Activity Related to the Use of Collagen Membranes: In Vitro Bioassays., PMID:32927851

Effect of NADPH oxidase inhibitors in an experimental retinal model of excitotoxicity., PMID:32916159

Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype., PMID:32868298

Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis., PMID:32478392

Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease., PMID:32240965

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors., PMID:32122909

TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway., PMID:32082074

Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy., PMID:32024241

Nox4-mediated ROS production is involved, but not essential for TGFβ-induced lens EMT leading to cataract., PMID:31926131

Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins., PMID:31919083

Dexamethasone and Tofacitinib suppress NADPH oxidase expression and alleviate very-early-onset ileocolitis in mice deficient in GSH peroxidase 1 and 2., PMID:31689440

Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling., PMID:31419440

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation., PMID:31302140

Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution., PMID:31247506

A novel NADPH oxidase inhibitor targeting Nox4 in TGFβ-induced lens epithelial to mesenchymal transition., PMID:31189078

Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes., PMID:31185450

Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR., PMID:31172474

Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity., PMID:31098627

Tumor necrosis factor alpha has a crucial role in increased reactive oxygen species production in platelets of mice injected with lipopolysaccharide., PMID:31076004

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation., PMID:30771750

Paricalcitol attenuates TGF-β1-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome., PMID:30354670

NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR., PMID:30237423

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