Catalog No.
YHD23401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser651-Ala936
Predicted molecular weight
34.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17301
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B
Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury., PMID:40462215
ITGB3 and associated molecules as critical biomarkers in Cesarean Scar Pregnancy., PMID:40442657
Inhibitory effects of β-galactoside α2,6-sialyltransferase 1 on the Hippo pathway in breast cancer cells., PMID:40409546
Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin-411 and Its Derived Peptide., PMID:40342064
Harnessing the bishomolithocholic acid scaffold for selective sialyltransferase inhibition: A targeted approach to suppress breast cancer metastasis., PMID:40324300
Enhancer-Associated LncRNA-ITGA2 Promotes Vascular Remodeling Through ITGA2., PMID:40321134
KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells., PMID:40316546
Upregulation of Fcγ Receptor IV on Activated Monocytes and Macrophages Causes Nonspecific Binding of the PK136 Anti-NK1.1 Antibody in Murine Models of Toll-Like Receptor-Induced Inflammation., PMID:40275544
Management of a twin pregnancy patient with Glanzmann thrombasthenia might be caused by a novel ITGA2B gene mutation (c.2822G>A): a case report and family investigation., PMID:40126091
Integrin stimulation by collagen I at the progenitor stage accelerates maturation of human iPSC-derived cardiomyocytes., PMID:40023481
Solobacterium moorei promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer., PMID:39990665
hsa_circ_0001599 promotes odontogenic differentiation of human dental pulp stem cells by increasing ITGA2 expression and stability., PMID:39825107
Egg allergen-specific T-cell and cytokine responses in healthy and egg-allergic children naturally tolerating baked egg., PMID:39803990
[Analysis of Genes Related to Platelet Activation in Essential Thrombocythemia Based on Transcriptomics]., PMID:39743270
Activin A promoted the anti-tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma., PMID:39727149
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration., PMID:39666682
Impact of vascular Ehlers-Danlos Syndrome-associated Gly substitutions on structure, function, and mechanics using bacterial collagen., PMID:39645092
The associations of candidate gene polymorphisms with aspirin resistance in patients with ischemic disease: a meta-analysis., PMID:39617913
Serum integrin accumulation during asthma exacerbation: The role of matrix metalloproteinases., PMID:39511761
Integrin α2β1 deficiency enhances osteogenesis via BMP-2 signaling for accelerated fracture repair., PMID:39500403
Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells., PMID:39316261
Hypoxia induces reversible gill remodeling in largemouth bass (Micropterus salmoides) through integrins-mediated cell adhesion., PMID:39307257
Recent advances in anticancer mechanisms of molecular glue degraders: focus on RBM39-dgrading synthetic sulfonamide such as indisulam, E7820, tasisulam, and chloroquinoxaline sulfonamide., PMID:39271535
Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis., PMID:39220682
PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell., PMID:39199378
Fibroblast growth factor 2 enhances BMSC stemness through ITGA2-dependent PI3K/AKT pathway activation., PMID:39188080
Electroacupuncture attenuates depressive-like behaviors in poststroke depression mice through promoting hippocampal neurogenesis and inhibiting TLR4/NF-κB/NLRP3 signaling pathway., PMID:39166408
Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy., PMID:39147240
Specific sialylation of N-glycans and its novel regulatory mechanism., PMID:38958800
[Pedigree Analysis and Molecular Mechanism Study of Hereditary Glanzmann Thrombasthenia Caused by Compound Heterozygous Mutation of the ITGA2B Gene]., PMID:38951065
Thrombospondin-4 deletion does not exacerbate muscular dystrophy in β-sarcoglycan-deficient and laminin α2 chain-deficient mice., PMID:38926599
Stem-Cell-Regenerative and Protective Effects of Squid (Symplectoteuthis oualaniensis) Skin Collagen Peptides against H2O2-Induced Fibroblast Injury., PMID:38921566
A novel surface marker CD49d promotes TNF expression in oyster agranulocytes by mediating the MAPK pathway., PMID:38897309
Selumetinib overcomes ITGA2-induced 5-fluorouracil resistance in colorectal cancer., PMID:38889513
Comprehensive proteomic profiling of lung adenocarcinoma: development and validation of an innovative prognostic model., PMID:38881920
DOT1L maintains NK cell phenotype and function for optimal tumor control., PMID:38865244
Landscape of extrachromosomal circular DNAs, transcriptome, and proteome analysis reveals insights into alcoholic liver cirrhosis., PMID:38782221
Mesenchymal Stem Cells from the Deciduous Tooth Pulp Lose their Ability to Suppress the Differentiation of Dendritic Cells during Long-Term Culturing., PMID:38733483
MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3., PMID:38702644
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence., PMID:38640717
Full-length αIIbβ3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture., PMID:38579706
Inhibition of platelet adhesion to exposed subendothelial collagen by steric hindrance with blocking peptide nanoparticles., PMID:38520952
Effects of the application of low-temperature atmospheric plasma on titanium implants on wound healing in peri-implant connective tissue in rats., PMID:38509336
N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease., PMID:38490094
Potential Mechanism of Platelet GPIIb/IIIa and Fibrinogen on Retinal Vein Occlusion., PMID:38482878
A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine., PMID:38436662
A novel ITGA2B double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat., PMID:38426552
Immunogenicity and protective efficacy of a trimeric full-length S protein subunit vaccine for porcine epidemic diarrhea virus., PMID:38220489
Integrated Analysis of DNA Methylation and Gene Expression Profiles in a Rat Model of Osteoarthritis., PMID:38203768
Dampened Regulatory Circuitry of TEAD1/ITGA1/ITGA2 Promotes TGFβ1 Signaling to Orchestrate Prostate Cancer Progression., PMID:38169150
For research use only. Not for human or drug use.
